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A1VJ23 (GLPK_POLNA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol kinase
EC=2.7.1.30
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK
Gene names
Name:glpK
Ordered Locus Names:Pnap_0328
OrganismPolaromonas naphthalenivorans (strain CJ2) [Complete proteome] [HAMAP]
Taxonomic identifier365044 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Polaromonas

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism By similarity. HAMAP MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glycerol kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Glycerol kinase HAMAP MF_00186
PRO_1000098748

Regions

Nucleotide binding412 – 4165ATP By similarity

Sites

Binding site111Substrate By similarity
Binding site151ATP By similarity
Binding site811Substrate By similarity
Binding site1331Substrate By similarity
Binding site2421Substrate By similarity
Binding site2641ATP By similarity
Binding site3071ATP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
A1VJ23 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 8CFC3A7D9070E617

FASTA49753,154
        10         20         30         40         50         60 
MAYLLALDQG TSSSRSIVFD EEGRVVALAQ RELPQIYPRP GWVEHDPMEI WRGQLATARQ 

        70         80         90        100        110        120 
ALASVGLAAW DIRAMGITNQ RETTVLWNRR TGQPVHHAIV WQDRRAESTC AQLREQGHEA 

       130        140        150        160        170        180 
LIQAKTGLLI DAYFSGTKLK WLLDNVAGVR AQAERGELAF GTIDSWLIWQ LTGGTVHATD 

       190        200        210        220        230        240 
VSNASRTMLF NVRTNQWDAE LLDLLGIPAS LMPEVKPSSA HYGEVRPELL GHAIPIGGVA 

       250        260        270        280        290        300 
GDQQSALFGQ ACFRAGMAKN TYGTGCFLLM HTGAQFQASK NGLLTTSAAQ TTAQTEFALE 

       310        320        330        340        350        360 
GSVFVGGAVV QWLRDGLHAI QGSAEVEALA QSVPDSGGVM MVPAFTGLGA PYWKPEARGT 

       370        380        390        400        410        420 
ITGLTRGTTM AHIARAALES IAYQSAALLL AMSRDAVAAG AAPLAELRVD GGASSNDLLM 

       430        440        450        460        470        480 
QFQADLLGIP VIRPAVTETT ALGAAWLAGL SSGVYGSTDE LSSLWRAERT FLPTLSTGRA 

       490 
AELMAQWEHA VRQTVLA

« Hide

References

[1]"Complete sequence of chromosome 1 of Polaromonas naphthalenivorans CJ2."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D.R., Brettin T., Bruce D., Han C., Tapia R., Brainard J., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Madsen E.L., Richardson P.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CJ2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000529 Genomic DNA. Translation: ABM35651.1.
RefSeqYP_980572.1. NC_008781.1.

3D structure databases

ProteinModelPortalA1VJ23.
SMRA1VJ23. Positions 3-494.
ModBaseSearch...

Protein-protein interaction databases

STRINGA1VJ23.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4687193.
GenomeReviewsGene locus Pnap_0328 in contig CP000529_GR.
KEGGpna:Pnap_0328.
PATRIC22945153. VBIPolNap76733_1146.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0554.
HOGENOMHBG511469.
OMAATYFSGT.
PhylomeDBA1VJ23.
ProtClustDBCLSK897540.

Enzyme and pathway databases

BioCycPNAP365044:PNAP_0328-MONOMER.

Family and domain databases

HAMAPMF_00186. Glycerol_kin.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
KOK00864.
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. Glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLPK_POLNA
AccessionPrimary (citable) accession number: A1VJ23
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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