A1VHE3 (A1VHE3_DESVV) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase HAMAP MF_00222
EC=1.1.1.25 HAMAP MF_00222

Gene names

Name:	aroE HAMAP MF_00222
Ordered Locus Names:	Dvul_2848

Organism

Desulfovibrio vulgaris subsp. vulgaris (strain DP4) [Complete proteome] [HAMAP]

Taxonomic identifier

391774 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222 SAAS SAAS011342
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222 SAAS SAAS011342
Sequence similarities	Belongs to the shikimate dehydrogenase family. HAMAP MF_00222

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP MF_00222 SAAS SAAS011342
Ligand	NADP HAMAP MF_00222 SAAS SAAS011342
Molecular function	Oxidoreductase HAMAP MF_00222 RuleBase RU004037 SAAS SAAS011342 EMBL ABM29859.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	156 – 160	5	NADP By similarity HAMAP MF_00222
Sites
	Active site	98	1	Proton acceptor By similarity HAMAP MF_00222

Sequences

	Sequence		Length	Mass (Da)
	A1VHE3 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: F8282075E36B261B	FASTA	301	32,064
	10 20 30 40 50 60 MSAPIPTRSV KLSQSPCAAD SSESAHRVPF RIPERLYGIV GHPLGHTLSP LLHNWGFALH 70 80 90 100 110 120 SLPAVYMAWP VPPGRFASFM EAVRTLPVHG ASVTIPHKEE ALRLCDRVTD RARAVGAVNT 130 140 150 160 170 180 LFLEGGVVCG ENTDVTGFLA PLRARGVRID EALVLGAGGA ARAVLAGLVE LGVRRVRISN 190 200 210 220 230 240 RTHDKAMELA GAFGADVVPW DERGSAAAGL VVNTTPCGMQ GARMGESPLP DGAFTGRGMA 250 260 270 280 290 300 YDLVYNPLTT RFLADARAAG WETQDGLGMF VEQGREQFRI WTGLDLPAEG ARRLIAEALG L

References

[1]

"Contribution of mobile genetic elements to Desulfovibrio vulgaris genome plasticity." Walker C.B., Stolyar S., Chivian D., Pinel N., Gabster J.A., Dehal P.S., He Z., Yang Z.K., Yen H.C., Zhou J., Wall J.D., Hazen T.C., Arkin A.P., Stahl D.A. Environ. Microbiol. 11:2244-2252(2009) [PubMed: 19737303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000527 Genomic DNA. Translation: ABM29859.1.
RefSeq	YP_968286.1. NC_008751.1.
3D structure databases
ProteinModelPortal	A1VHE3.
ModBase	Search...
Protein-protein interaction databases
STRING	A1VHE3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4663982.
GenomeReviews	Gene locus Dvul_2848 in contig CP000527_GR.
KEGG	dvl:Dvul_2848.
NMPDR	fig|391774.5.peg.2740.
PATRIC	21769622. VBIDesVul62463_3063.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
HOGENOM	HBG553408.
OMA	LHLKTHG.
PhylomeDB	A1VHE3.
ProtClustDB	CLSK704419.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A1VHE3_DESVV

Accession

Primary (citable) accession number: A1VHE3

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)