Reviewed, UniProtKB/Swiss-Prot A1VFZ7 (SAHH_DESVV)

Names and origin

Protein names

Recommended name:
    Adenosylhomocysteinase
    EC=3.3.1.1
Alternative name(s):
    S-adenosyl-L-homocysteine hydrolase
      Short name=AdoHcyase

Gene names

Name:	ahcY
Ordered Locus Names:	Dvul_2347

Organism

Desulfovibrio vulgaris subsp. vulgaris (strain DP4) [Complete proteome] [HAMAP]

Taxonomic identifier

391774 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio

Protein attributes

Sequence length	479 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. HAMAP MF_00563
Cofactor	Binds 1 NAD per subunit By similarity.
Pathway	Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. HAMAP MF_00563
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the adenosylhomocysteinase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenosylhomocysteinase activity Inferred from electronic annotation. Source: HAMAP binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 479	479	Adenosylhomocysteinase HAMAP MF_00563		PRO_1000024725
Regions
	Region	230 – 398	169	NAD binding By similarity
Sites
	Binding site	66	1	Substrate By similarity
	Binding site	142	1	Substrate By similarity
	Binding site	203	1	Substrate By similarity
	Binding site	233	1	Substrate By similarity
	Binding site	237	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1VFZ7-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 27881713CC2C80B1	FASTA	479	52,897
	10 20 30 40 50 60 MTDAKRAQKL DLSLDHKVAD MSLADYGRKD LQLSEREMPG LMELIRKYGG TKPLKGLKVT 70 80 90 100 110 120 GSLHMTIQTA MLIRTLYELG ADIRWASCNI FSTQDHAAAA IAASGMAKVF AWKGETLEDY 130 140 150 160 170 180 WWCTEMALTW PDGSGPDLLV DDGGDATLFI HKGVEVENDP SLLKKAYDNK EFQIIMDRLA 190 200 210 220 230 240 LAYEQDPGRW QRVAAKVRGV SEETTTGVHR LYQLEQEGKL LFPAINVNDA VTKSKFDNLY 250 260 270 280 290 300 GCRESLADGI KRATDVMVAG KVVVVAGYGD VGKGCAQSMR GFGARVLVTE IDPICALQAA 310 320 330 340 350 360 MEGYEVTTME EAVRTGDIFV TATGNCNVIT GAHMEAMKDE AIVCNIGHFD NEIDMHYLEN 370 380 390 400 410 420 TEGCVCLNIK PQVDKWTLRS GRSIIVLAEG RLVNLGCATG HPSFVMSASF TNQTLAQIEL 430 440 450 460 470 ATNPDLERKV YTLPKKLDEE VARLHLDRLG VKLTRLSKDQ ADYIGVSPEG PFKPDHYRY

References

[1]

"Complete sequence of chromosome 1 of Desulfovibrio vulgaris subsp. vulgaris DP4." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Lykidis A., Walker C., Richardson P. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000527 Genomic DNA. Translation: ABM29363.1.
RefSeq	YP_967790.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1VFZ7.
Genome annotation databases
GeneID	4662413.
GenomeReviews	Gene locus Dvul_2347 in contig CP000527_GR.
KEGG	dvl:Dvul_2347.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	HMRAMKD.
Family and domain databases
HAMAP	MF_00563. [Tree]
InterPro	IPR015878. Ado_hCys_hydrolase_NAD-bd. IPR000043. S-Ado-L-homoCys_hydrolase. IPR020082. S-Ado-L-homoCys_hydrolase_CS. [Graphical view]
PANTHER	PTHR23420. Ad_hcy_hydrolase. 1 hit.
Pfam	PF05221. AdoHcyase. 1 hit. PF00670. AdoHcyase_NAD. 1 hit. [Graphical view]
PIRSF	PIRSF001109. Ad_hcy_hydrolase. 1 hit.
TIGRFAMs	TIGR00936. ahcY. 1 hit.
PROSITE	PS00738. ADOHCYASE_1. 1 hit. PS00739. ADOHCYASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SAHH_DESVV

Accession

Primary (citable) accession number: A1VFZ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	November 3, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)