A1VFC7 (A1VFC7_DESVV) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Porphobilinogen synthase EMBL ABM29143.1
EC=4.2.1.24 EMBL ABM29143.1

Gene names

Ordered Locus Names:

Dvul_2127

Organism

Desulfovibrio vulgaris subsp. vulgaris (strain DP4) [Complete proteome] [HAMAP]

Taxonomic identifier

391774 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subunit structure	Homooctamer By similarity. PIRSR PIRSR001415-3
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-3 Zinc PIRSR PIRSR001415-3
Molecular function	Lyase EMBL ABM29143.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tetrapyrrole biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	200	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	253	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	121	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	123	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	131	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	238	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	210	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	222	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	279	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	318	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	A1VFC7 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: F041AE93F4B44AB6	FASTA	330	36,360
	10 20 30 40 50 60 MGDFFRGRRL RRTAALRELV RENVVCAADL IMPYFVVETD APAFRKEIGA MPGQFQLSLQ 70 80 90 100 110 120 ELEKQVEAAV AKGLRAVILF GIPKVKDYKG SEAYNKDGIV QQAVRLLKKR WPALVVVTDV 130 140 150 160 170 180 CLCEYTDHGH CGLVRQGDTS GEVHNDPTLS LLTKAAVSHA EAGADIVAPS DMMDGRVQAI 190 200 210 220 230 240 RAGLDANGFS HIPVMSYAVK YASSFYGPFR EAAESTPQFG DRKTYQMDPA NSREAMREAA 250 260 270 280 290 300 ADVDEDADFL IVKPAGPYLD IIRQVRDNFD LPVVAYQVSG EYSMIRAAGI NGWINEEAVI 310 320 330 MESLLGMKRA GCDLIITYFT EELLAKGLVR

References

[1]

"Contribution of mobile genetic elements to Desulfovibrio vulgaris genome plasticity." Walker C.B., Stolyar S., Chivian D., Pinel N., Gabster J.A., Dehal P.S., He Z., Yang Z.K., Yen H.C., Zhou J., Wall J.D., Hazen T.C., Arkin A.P., Stahl D.A. Environ. Microbiol. 11:2244-2252(2009) [PubMed: 19737303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000527 Genomic DNA. Translation: ABM29143.1.
RefSeq	YP_967570.1. NC_008751.1.
3D structure databases
ProteinModelPortal	A1VFC7.
SMR	A1VFC7. Positions 5-324.
ModBase	Search...
Protein-protein interaction databases
STRING	A1VFC7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4663506.
GenomeReviews	Gene locus Dvul_2127 in contig CP000527_GR.
KEGG	dvl:Dvul_2127.
NMPDR	fig|391774.5.peg.2091.
PATRIC	21768160. VBIDesVul62463_2350.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0113.
HOGENOM	HBG285270.
OMA	ADLCFCE.
PhylomeDB	A1VFC7.
ProtClustDB	PRK09283.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A1VFC7_DESVV

Accession

Primary (citable) accession number: A1VFC7

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)