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A1VEW8

- UPP_DESVV

UniProt

A1VEW8 - UPP_DESVV

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Protein

Uracil phosphoribosyltransferase

Gene

upp

Organism
Desulfovibrio vulgaris subsp. vulgaris (strain DP4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.UniRule annotation

Enzyme regulationi

Allosterically activated by GTP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei78 – 7815-phospho-alpha-D-ribose 1-diphosphateUniRule annotation
Binding sitei103 – 10315-phospho-alpha-D-ribose 1-diphosphateUniRule annotation
Binding sitei193 – 1931Uracil; via amide nitrogenUniRule annotation
Binding sitei199 – 19915-phospho-alpha-D-ribose 1-diphosphateUniRule annotation

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. uracil phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. UMP salvage Source: UniProtKB-UniPathway
  2. uracil salvage Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

GTP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciDVUL391774:GHS0-2026-MONOMER.
UniPathwayiUPA00574; UER00636.

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Alternative name(s):
UMP pyrophosphorylaseUniRule annotation
UPRTaseUniRule annotation
Gene namesi
Name:uppUniRule annotation
Ordered Locus Names:Dvul_1968
OrganismiDesulfovibrio vulgaris subsp. vulgaris (strain DP4)
Taxonomic identifieri391774 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000009173: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Uracil phosphoribosyltransferasePRO_1000053715Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391774.Dvul_1968.

Structurei

3D structure databases

ProteinModelPortaliA1VEW8.
SMRiA1VEW8. Positions 6-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 13895-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation
Regioni198 – 2003Uracil bindingUniRule annotation

Sequence similaritiesi

Belongs to the UPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0035.
HOGENOMiHOG000262754.
KOiK00761.
OMAiDVHIYTA.
OrthoDBiEOG6HF5WX.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01218_B. Upp_B.
InterProiIPR029057. PRTase-like.
IPR005765. Ura_phspho_trans.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01091. upp. 1 hit.

Sequencei

Sequence statusi: Complete.

A1VEW8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVYVVDHPL VKHKLGRLRQ HDVPVSEFRA IANELCRLLA YEATKDLETE
60 70 80 90 100
KVSVQGWAGP VEVDQIKGKK ITAVPILRAG LGMLDGFLDM IPGAKVSVVG
110 120 130 140 150
MFRNEETLEP VQYYTKLAKN IDERMAVILD PMLATGGTLD ATIDLLKNAG
160 170 180 190 200
CPQIKGLFLV AAPEGLKRIV DKHPDVDIYV AAVDERLNEH GYILPGLGDA

GDKIFGTK
Length:208
Mass (Da):22,729
Last modified:February 6, 2007 - v1
Checksum:iC1C5DA6B20F852DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000527 Genomic DNA. Translation: ABM28984.1.
RefSeqiYP_967411.1. NC_008751.1.

Genome annotation databases

EnsemblBacteriaiABM28984; ABM28984; Dvul_1968.
GeneIDi4663329.
KEGGidvl:Dvul_1968.
PATRICi21767818. VBIDesVul62463_2181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000527 Genomic DNA. Translation: ABM28984.1 .
RefSeqi YP_967411.1. NC_008751.1.

3D structure databases

ProteinModelPortali A1VEW8.
SMRi A1VEW8. Positions 6-208.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391774.Dvul_1968.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM28984 ; ABM28984 ; Dvul_1968 .
GeneIDi 4663329.
KEGGi dvl:Dvul_1968.
PATRICi 21767818. VBIDesVul62463_2181.

Phylogenomic databases

eggNOGi COG0035.
HOGENOMi HOG000262754.
KOi K00761.
OMAi DVHIYTA.
OrthoDBi EOG6HF5WX.

Enzyme and pathway databases

UniPathwayi UPA00574 ; UER00636 .
BioCyci DVUL391774:GHS0-2026-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01218_B. Upp_B.
InterProi IPR029057. PRTase-like.
IPR005765. Ura_phspho_trans.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
TIGRFAMsi TIGR01091. upp. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DP4.

Entry informationi

Entry nameiUPP_DESVV
AccessioniPrimary (citable) accession number: A1VEW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: November 26, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3