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A1VEW8

- UPP_DESVV

UniProt

A1VEW8 - UPP_DESVV

Protein

Uracil phosphoribosyltransferase

Gene

upp

Organism
Desulfovibrio vulgaris subsp. vulgaris (strain DP4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.UniRule annotation

    Catalytic activityi

    UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

    Cofactori

    Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.UniRule annotation

    Enzyme regulationi

    Allosterically activated by GTP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei78 – 7815-phospho-alpha-D-ribose 1-diphosphateUniRule annotation
    Binding sitei103 – 10315-phospho-alpha-D-ribose 1-diphosphateUniRule annotation
    Binding sitei193 – 1931Uracil; via amide nitrogenUniRule annotation
    Binding sitei199 – 19915-phospho-alpha-D-ribose 1-diphosphateUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. uracil phosphoribosyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. UMP salvage Source: UniProtKB-UniPathway
    2. uracil salvage Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Ligandi

    GTP-binding, Magnesium, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDVUL391774:GHS0-2026-MONOMER.
    UniPathwayiUPA00574; UER00636.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
    Alternative name(s):
    UMP pyrophosphorylaseUniRule annotation
    UPRTaseUniRule annotation
    Gene namesi
    Name:uppUniRule annotation
    Ordered Locus Names:Dvul_1968
    OrganismiDesulfovibrio vulgaris subsp. vulgaris (strain DP4)
    Taxonomic identifieri391774 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
    ProteomesiUP000009173: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 208208Uracil phosphoribosyltransferasePRO_1000053715Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi391774.Dvul_1968.

    Structurei

    3D structure databases

    ProteinModelPortaliA1VEW8.
    SMRiA1VEW8. Positions 6-208.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni130 – 13895-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation
    Regioni198 – 2003Uracil bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the UPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0035.
    HOGENOMiHOG000262754.
    KOiK00761.
    OMAiDVHIYTA.
    OrthoDBiEOG6HF5WX.

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    HAMAPiMF_01218_B. Upp_B.
    InterProiIPR029057. PRTase-like.
    IPR005765. Ura_phspho_trans.
    [Graphical view]
    SUPFAMiSSF53271. SSF53271. 1 hit.
    TIGRFAMsiTIGR01091. upp. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1VEW8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVYVVDHPL VKHKLGRLRQ HDVPVSEFRA IANELCRLLA YEATKDLETE    50
    KVSVQGWAGP VEVDQIKGKK ITAVPILRAG LGMLDGFLDM IPGAKVSVVG 100
    MFRNEETLEP VQYYTKLAKN IDERMAVILD PMLATGGTLD ATIDLLKNAG 150
    CPQIKGLFLV AAPEGLKRIV DKHPDVDIYV AAVDERLNEH GYILPGLGDA 200
    GDKIFGTK 208
    Length:208
    Mass (Da):22,729
    Last modified:February 6, 2007 - v1
    Checksum:iC1C5DA6B20F852DB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000527 Genomic DNA. Translation: ABM28984.1.
    RefSeqiWP_010938324.1. NC_008751.1.
    YP_967411.1. NC_008751.1.

    Genome annotation databases

    EnsemblBacteriaiABM28984; ABM28984; Dvul_1968.
    GeneIDi4663329.
    KEGGidvl:Dvul_1968.
    PATRICi21767818. VBIDesVul62463_2181.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000527 Genomic DNA. Translation: ABM28984.1 .
    RefSeqi WP_010938324.1. NC_008751.1.
    YP_967411.1. NC_008751.1.

    3D structure databases

    ProteinModelPortali A1VEW8.
    SMRi A1VEW8. Positions 6-208.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391774.Dvul_1968.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM28984 ; ABM28984 ; Dvul_1968 .
    GeneIDi 4663329.
    KEGGi dvl:Dvul_1968.
    PATRICi 21767818. VBIDesVul62463_2181.

    Phylogenomic databases

    eggNOGi COG0035.
    HOGENOMi HOG000262754.
    KOi K00761.
    OMAi DVHIYTA.
    OrthoDBi EOG6HF5WX.

    Enzyme and pathway databases

    UniPathwayi UPA00574 ; UER00636 .
    BioCyci DVUL391774:GHS0-2026-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    HAMAPi MF_01218_B. Upp_B.
    InterProi IPR029057. PRTase-like.
    IPR005765. Ura_phspho_trans.
    [Graphical view ]
    SUPFAMi SSF53271. SSF53271. 1 hit.
    TIGRFAMsi TIGR01091. upp. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DP4.

    Entry informationi

    Entry nameiUPP_DESVV
    AccessioniPrimary (citable) accession number: A1VEW8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3