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A1VEW8

- UPP_DESVV

UniProt

A1VEW8 - UPP_DESVV

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Protein
Uracil phosphoribosyltransferase
Gene
upp, Dvul_1968
Organism
Desulfovibrio vulgaris subsp. vulgaris (strain DP4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate By similarity.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP By similarity.

Enzyme regulationi

Allosterically activated by GTP By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei78 – 7815-phospho-alpha-D-ribose 1-diphosphate By similarity
Binding sitei103 – 10315-phospho-alpha-D-ribose 1-diphosphate By similarity
Binding sitei193 – 1931Uracil; via amide nitrogen By similarity
Binding sitei199 – 19915-phospho-alpha-D-ribose 1-diphosphate By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. uracil phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. UMP salvage Source: UniProtKB-UniPathway
  2. uracil salvage Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

GTP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciDVUL391774:GHS0-2026-MONOMER.
UniPathwayiUPA00574; UER00636.

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil phosphoribosyltransferase (EC:2.4.2.9)
Alternative name(s):
UMP pyrophosphorylase
UPRTase
Gene namesi
Name:upp
Ordered Locus Names:Dvul_1968
OrganismiDesulfovibrio vulgaris subsp. vulgaris (strain DP4)
Taxonomic identifieri391774 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000009173: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Uracil phosphoribosyltransferaseUniRule annotation
PRO_1000053715Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391774.Dvul_1968.

Structurei

3D structure databases

ProteinModelPortaliA1VEW8.
SMRiA1VEW8. Positions 6-208.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 13895-phospho-alpha-D-ribose 1-diphosphate binding By similarity
Regioni198 – 2003Uracil binding By similarity

Sequence similaritiesi

Belongs to the UPRTase family.

Phylogenomic databases

eggNOGiCOG0035.
HOGENOMiHOG000262754.
KOiK00761.
OMAiDVHIYTA.
OrthoDBiEOG6HF5WX.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01218_B. Upp_B.
InterProiIPR029057. PRTase-like.
IPR005765. Ura_phspho_trans.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01091. upp. 1 hit.

Sequencei

Sequence statusi: Complete.

A1VEW8-1 [UniParc]FASTAAdd to Basket

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MAVYVVDHPL VKHKLGRLRQ HDVPVSEFRA IANELCRLLA YEATKDLETE    50
KVSVQGWAGP VEVDQIKGKK ITAVPILRAG LGMLDGFLDM IPGAKVSVVG 100
MFRNEETLEP VQYYTKLAKN IDERMAVILD PMLATGGTLD ATIDLLKNAG 150
CPQIKGLFLV AAPEGLKRIV DKHPDVDIYV AAVDERLNEH GYILPGLGDA 200
GDKIFGTK 208
Length:208
Mass (Da):22,729
Last modified:February 6, 2007 - v1
Checksum:iC1C5DA6B20F852DB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000527 Genomic DNA. Translation: ABM28984.1.
RefSeqiWP_010938324.1. NC_008751.1.
YP_967411.1. NC_008751.1.

Genome annotation databases

EnsemblBacteriaiABM28984; ABM28984; Dvul_1968.
GeneIDi4663329.
KEGGidvl:Dvul_1968.
PATRICi21767818. VBIDesVul62463_2181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000527 Genomic DNA. Translation: ABM28984.1 .
RefSeqi WP_010938324.1. NC_008751.1.
YP_967411.1. NC_008751.1.

3D structure databases

ProteinModelPortali A1VEW8.
SMRi A1VEW8. Positions 6-208.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391774.Dvul_1968.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM28984 ; ABM28984 ; Dvul_1968 .
GeneIDi 4663329.
KEGGi dvl:Dvul_1968.
PATRICi 21767818. VBIDesVul62463_2181.

Phylogenomic databases

eggNOGi COG0035.
HOGENOMi HOG000262754.
KOi K00761.
OMAi DVHIYTA.
OrthoDBi EOG6HF5WX.

Enzyme and pathway databases

UniPathwayi UPA00574 ; UER00636 .
BioCyci DVUL391774:GHS0-2026-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01218_B. Upp_B.
InterProi IPR029057. PRTase-like.
IPR005765. Ura_phspho_trans.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
TIGRFAMsi TIGR01091. upp. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DP4.

Entry informationi

Entry nameiUPP_DESVV
AccessioniPrimary (citable) accession number: A1VEW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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