Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A1VEW8 (UPP_DESVV) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uracil phosphoribosyltransferase

EC=2.4.2.9
Alternative name(s):
UMP pyrophosphorylase
UPRTase
Gene names
Name:upp
Ordered Locus Names:Dvul_1968
OrganismDesulfovibrio vulgaris subsp. vulgaris (strain DP4) [Complete proteome] [HAMAP]
Taxonomic identifier391774 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate By similarity. HAMAP-Rule MF_01218

Catalytic activity

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_01218

Cofactor

Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP By similarity.

Enzyme regulation

Allosterically activated by GTP By similarity. HAMAP-Rule MF_01218

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1. HAMAP-Rule MF_01218

Sequence similarities

Belongs to the UPRTase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 208208Uracil phosphoribosyltransferase HAMAP-Rule MF_01218
PRO_1000053715

Regions

Region130 – 13895-phospho-alpha-D-ribose 1-diphosphate binding By similarity
Region198 – 2003Uracil binding By similarity

Sites

Binding site7815-phospho-alpha-D-ribose 1-diphosphate By similarity
Binding site10315-phospho-alpha-D-ribose 1-diphosphate By similarity
Binding site1931Uracil; via amide nitrogen By similarity
Binding site19915-phospho-alpha-D-ribose 1-diphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
A1VEW8 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: C1C5DA6B20F852DB

FASTA20822,729
        10         20         30         40         50         60 
MAVYVVDHPL VKHKLGRLRQ HDVPVSEFRA IANELCRLLA YEATKDLETE KVSVQGWAGP 

        70         80         90        100        110        120 
VEVDQIKGKK ITAVPILRAG LGMLDGFLDM IPGAKVSVVG MFRNEETLEP VQYYTKLAKN 

       130        140        150        160        170        180 
IDERMAVILD PMLATGGTLD ATIDLLKNAG CPQIKGLFLV AAPEGLKRIV DKHPDVDIYV 

       190        200 
AAVDERLNEH GYILPGLGDA GDKIFGTK 

« Hide

References

[1]"Contribution of mobile genetic elements to Desulfovibrio vulgaris genome plasticity."
Walker C.B., Stolyar S., Chivian D., Pinel N., Gabster J.A., Dehal P.S., He Z., Yang Z.K., Yen H.C., Zhou J., Wall J.D., Hazen T.C., Arkin A.P., Stahl D.A.
Environ. Microbiol. 11:2244-2252(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DP4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000527 Genomic DNA. Translation: ABM28984.1.
RefSeqYP_967411.1. NC_008751.1.

3D structure databases

ProteinModelPortalA1VEW8.
SMRA1VEW8. Positions 6-208.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING391774.Dvul_1968.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM28984; ABM28984; Dvul_1968.
GeneID4663329.
KEGGdvl:Dvul_1968.
PATRIC21767818. VBIDesVul62463_2181.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0035.
HOGENOMHOG000262754.
KOK00761.
OMADVHIYTA.
OrthoDBEOG6HF5WX.

Enzyme and pathway databases

BioCycDVUL391774:GHS0-2026-MONOMER.
UniPathwayUPA00574; UER00636.

Family and domain databases

Gene3D3.40.50.2020. 1 hit.
HAMAPMF_01218_B. Upp_B.
InterProIPR029057. PRTase-like.
IPR005765. Ura_phspho_trans.
[Graphical view]
SUPFAMSSF53271. SSF53271. 1 hit.
TIGRFAMsTIGR01091. upp. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPP_DESVV
AccessionPrimary (citable) accession number: A1VEW8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: June 11, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways