A1VEW8 (UPP_DESVV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uracil phosphoribosyltransferase
EC=2.4.2.9

Alternative name(s):
UMP pyrophosphorylase
UPRTase

Gene names

Name:	upp
Ordered Locus Names:	Dvul_1968

Organism

Desulfovibrio vulgaris subsp. vulgaris (strain DP4) [Complete proteome] [HAMAP]

Taxonomic identifier

391774 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio › Desulfovibrio vulgaris

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate By similarity. HAMAP-Rule MF_01218
Catalytic activity	UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_01218
Cofactor	Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP By similarity.
Enzyme regulation	Allosterically activated by GTP By similarity. HAMAP-Rule MF_01218
Pathway	Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1. HAMAP-Rule MF_01218
Sequence similarities	Belongs to the UPRTase family.

Ontologies

Keywords
Ligand	GTP-binding Magnesium Nucleotide-binding
Molecular function	Glycosyltransferase Transferase
Technical term	Allosteric enzyme Complete proteome
Gene Ontology (GO)
Biological_process	UMP salvage Inferred from electronic annotation. Source: UniProtKB-UniPathway uracil salvage Inferred from electronic annotation. Source: InterPro
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: HAMAP uracil phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 208	208	Uracil phosphoribosyltransferase HAMAP-Rule MF_01218		PRO_1000053715
Regions
	Region	130 – 138	9	5-phospho-alpha-D-ribose 1-diphosphate binding By similarity
	Region	198 – 200	3	Uracil binding By similarity
Sites
	Binding site	78	1	5-phospho-alpha-D-ribose 1-diphosphate By similarity
	Binding site	103	1	5-phospho-alpha-D-ribose 1-diphosphate By similarity
	Binding site	193	1	Uracil; via amide nitrogen By similarity
	Binding site	199	1	5-phospho-alpha-D-ribose 1-diphosphate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1VEW8 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: C1C5DA6B20F852DB	FASTA	208	22,729
	10 20 30 40 50 60 MAVYVVDHPL VKHKLGRLRQ HDVPVSEFRA IANELCRLLA YEATKDLETE KVSVQGWAGP 70 80 90 100 110 120 VEVDQIKGKK ITAVPILRAG LGMLDGFLDM IPGAKVSVVG MFRNEETLEP VQYYTKLAKN 130 140 150 160 170 180 IDERMAVILD PMLATGGTLD ATIDLLKNAG CPQIKGLFLV AAPEGLKRIV DKHPDVDIYV 190 200 AAVDERLNEH GYILPGLGDA GDKIFGTK

References

[1]

"Contribution of mobile genetic elements to Desulfovibrio vulgaris genome plasticity." Walker C.B., Stolyar S., Chivian D., Pinel N., Gabster J.A., Dehal P.S., He Z., Yang Z.K., Yen H.C., Zhou J., Wall J.D., Hazen T.C., Arkin A.P., Stahl D.A. Environ. Microbiol. 11:2244-2252(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DP4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000527 Genomic DNA. Translation: ABM28984.1.
RefSeq	YP_967411.1. NC_008751.1.
3D structure databases
ProteinModelPortal	A1VEW8.
SMR	A1VEW8. Positions 6-208.
ModBase	Search...
Protein-protein interaction databases
STRING	391774.Dvul_1968.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABM28984; ABM28984; Dvul_1968.
GeneID	4663329.
KEGG	dvl:Dvul_1968.
PATRIC	21767818. VBIDesVul62463_2181.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0035.
HOGENOM	HOG000262754.
KO	K00761.
OMA	TIEGWCG.
ProtClustDB	PRK00129.
Enzyme and pathway databases
BioCyc	DVUL391774:GHS0-2054-MONOMER.
UniPathway	UPA00574; UER00636.
Family and domain databases
HAMAP	MF_01218_B. Upp_B.
InterPro	IPR000836. PRibTrfase_dom. IPR005765. Ura_phspho_trans. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01091. upp. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPP_DESVV

Accession

Primary (citable) accession number: A1VEW8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program