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A1VEL2

- SYL_DESVV

UniProt

A1VEL2 - SYL_DESVV

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Protein

Leucine--tRNA ligase

Gene
leuS, Dvul_1861
Organism
Desulfovibrio vulgaris subsp. vulgaris (strain DP4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei584 – 5841ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDVUL391774:GHS0-1918-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Dvul_1861
OrganismiDesulfovibrio vulgaris subsp. vulgaris (strain DP4)
Taxonomic identifieri391774 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000009173: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 829829Leucine--tRNA ligaseUniRule annotationPRO_1000009335Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391774.Dvul_1861.

Structurei

3D structure databases

ProteinModelPortaliA1VEL2.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5011"HIGH" regionUniRule annotationAdd
BLAST
Motifi581 – 5855"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1VEL2-1 [UniParc]FASTAAdd to Basket

« Hide

MKYDHQSIET RWQKKWEDSG IFQCDTEADK PKYYVLEMFP YPSGNIHMGH    50
VRNYSIGDVV ARFKRMQGFN VLHPMGWDAF GLPAENAAIK NGTHPAKWTF 100
ANIDNMRSQL KRLGYSYDWQ REVATCTPEY YRWEQLFFLR FLEKGLVYRK 150
KAAQNWCPKC HTVLANEQVI EGLCWRCDSA VEQKELTQWF LRITDYAEEL 200
LADLSKLENG WPERVLSMQR NWIGKSTGAE IRFALDGRDD SITVFTTRPD 250
TIFGATFMSI APEHPLVEEL IDGKPQADDV RAFVERIRNM DRIDRQSDTL 300
EKEGVFTGAY CVNPFTGRKM PIWVANFVLA EYGTGAVMAV PAHDQRDFEF 350
ARKYDLPMQV VIQPQGETLD PATMSAAWTE AGALVNSGNF DGLANEDAKQ 400
RIADDLETTG NGRRTINYRL RDWNISRQRY WGAPIPVIYC DACGVVPEKE 450
ENLPVVLPLD VKTHDDGRSP LPHTPAFYEC TCPVCGGKAR RETDTMDTFV 500
ESSWYFARYT DATNDKAPFT PDALRYWLPV DQYIGGVEHA ILHLLYSRFF 550
TKALRDCGFI ELDEPFANLL TQGMVLMDGS KMSKSKGNVV DPTEMIARYG 600
ADTVRLFCLF AAPPERDFDW SESGIEGSYR FVGRVWRLVE ELREHLLAVG 650
ACSSTAEDAK TPVARELRLK EHATVRKAGD DLNDRFQFNT AIAAVMELVN 700
ALYLAKDELV ADESGRKVLS SAVSTVLTLL SPFTPHLSEE LWALLGHTES 750
VSTLPWPRWK EDALVRDTVT LVVQVNGKLR GKLDIPADAS REEVETLALN 800
EPNVLRYLEG VTVRKVVVIP GKLVNVVVS 829
Length:829
Mass (Da):94,053
Last modified:February 6, 2007 - v1
Checksum:iB8342F1120C5FFF0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000527 Genomic DNA. Translation: ABM28878.1.
RefSeqiYP_967305.1. NC_008751.1.

Genome annotation databases

EnsemblBacteriaiABM28878; ABM28878; Dvul_1861.
GeneIDi4662758.
KEGGidvl:Dvul_1861.
PATRICi21767604. VBIDesVul62463_2075.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000527 Genomic DNA. Translation: ABM28878.1 .
RefSeqi YP_967305.1. NC_008751.1.

3D structure databases

ProteinModelPortali A1VEL2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391774.Dvul_1861.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM28878 ; ABM28878 ; Dvul_1861 .
GeneIDi 4662758.
KEGGi dvl:Dvul_1861.
PATRICi 21767604. VBIDesVul62463_2075.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci DVUL391774:GHS0-1918-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DP4.

Entry informationi

Entry nameiSYL_DESVV
AccessioniPrimary (citable) accession number: A1VEL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi