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A1VEL2

- SYL_DESVV

UniProt

A1VEL2 - SYL_DESVV

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Desulfovibrio vulgaris subsp. vulgaris (strain DP4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei584 – 5841ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDVUL391774:GHS0-1918-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Dvul_1861
    OrganismiDesulfovibrio vulgaris subsp. vulgaris (strain DP4)
    Taxonomic identifieri391774 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
    ProteomesiUP000009173: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 829829Leucine--tRNA ligasePRO_1000009335Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi391774.Dvul_1861.

    Structurei

    3D structure databases

    ProteinModelPortaliA1VEL2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5011"HIGH" regionAdd
    BLAST
    Motifi581 – 5855"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1VEL2-1 [UniParc]FASTAAdd to Basket

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    MKYDHQSIET RWQKKWEDSG IFQCDTEADK PKYYVLEMFP YPSGNIHMGH    50
    VRNYSIGDVV ARFKRMQGFN VLHPMGWDAF GLPAENAAIK NGTHPAKWTF 100
    ANIDNMRSQL KRLGYSYDWQ REVATCTPEY YRWEQLFFLR FLEKGLVYRK 150
    KAAQNWCPKC HTVLANEQVI EGLCWRCDSA VEQKELTQWF LRITDYAEEL 200
    LADLSKLENG WPERVLSMQR NWIGKSTGAE IRFALDGRDD SITVFTTRPD 250
    TIFGATFMSI APEHPLVEEL IDGKPQADDV RAFVERIRNM DRIDRQSDTL 300
    EKEGVFTGAY CVNPFTGRKM PIWVANFVLA EYGTGAVMAV PAHDQRDFEF 350
    ARKYDLPMQV VIQPQGETLD PATMSAAWTE AGALVNSGNF DGLANEDAKQ 400
    RIADDLETTG NGRRTINYRL RDWNISRQRY WGAPIPVIYC DACGVVPEKE 450
    ENLPVVLPLD VKTHDDGRSP LPHTPAFYEC TCPVCGGKAR RETDTMDTFV 500
    ESSWYFARYT DATNDKAPFT PDALRYWLPV DQYIGGVEHA ILHLLYSRFF 550
    TKALRDCGFI ELDEPFANLL TQGMVLMDGS KMSKSKGNVV DPTEMIARYG 600
    ADTVRLFCLF AAPPERDFDW SESGIEGSYR FVGRVWRLVE ELREHLLAVG 650
    ACSSTAEDAK TPVARELRLK EHATVRKAGD DLNDRFQFNT AIAAVMELVN 700
    ALYLAKDELV ADESGRKVLS SAVSTVLTLL SPFTPHLSEE LWALLGHTES 750
    VSTLPWPRWK EDALVRDTVT LVVQVNGKLR GKLDIPADAS REEVETLALN 800
    EPNVLRYLEG VTVRKVVVIP GKLVNVVVS 829
    Length:829
    Mass (Da):94,053
    Last modified:February 6, 2007 - v1
    Checksum:iB8342F1120C5FFF0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000527 Genomic DNA. Translation: ABM28878.1.
    RefSeqiYP_967305.1. NC_008751.1.

    Genome annotation databases

    EnsemblBacteriaiABM28878; ABM28878; Dvul_1861.
    GeneIDi4662758.
    KEGGidvl:Dvul_1861.
    PATRICi21767604. VBIDesVul62463_2075.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000527 Genomic DNA. Translation: ABM28878.1 .
    RefSeqi YP_967305.1. NC_008751.1.

    3D structure databases

    ProteinModelPortali A1VEL2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391774.Dvul_1861.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM28878 ; ABM28878 ; Dvul_1861 .
    GeneIDi 4662758.
    KEGGi dvl:Dvul_1861.
    PATRICi 21767604. VBIDesVul62463_2075.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci DVUL391774:GHS0-1918-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DP4.

    Entry informationi

    Entry nameiSYL_DESVV
    AccessioniPrimary (citable) accession number: A1VEL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3