A1VEK1 (FABH_DESVV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
EC=2.3.1.41

Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III
Beta-ketoacyl-ACP synthase III
Short name=KAS III

Gene names

Name:	fabH
Ordered Locus Names:	Dvul_1850

Organism

Desulfovibrio vulgaris subsp. vulgaris (strain DP4) [Complete proteome] [HAMAP]

Taxonomic identifier

391774 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815
Catalytic activity	Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein]. HAMAP MF_01815
Pathway	Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815
Subunit structure	Homodimer By similarity. HAMAP MF_01815
Subcellular location	Cytoplasm Probable HAMAP MF_01815.
Domain	The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815
Sequence similarities	Belongs to the FabH family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-oxoacyl-[acyl-carrier-protein] synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 330	330	3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815		PRO_1000056353
Regions
	Region	258 – 262	5	ACP-binding By similarity
Sites
	Active site	114	1	By similarity
	Active site	257	1	By similarity
	Active site	287	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1VEK1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 9452353FBBEB65EA	FASTA	330	34,666
	10 20 30 40 50 60 MTSPSLLRGF GAYAPERILT NADIESMVET TDEWITTRTG IRQRHVVAPG QTTSDLAVEA 70 80 90 100 110 120 ARAALADAAL DTADITHVLV ATCTPDASCP NTACIVARKL GMTGVMALDC NAACSGFLYG 130 140 150 160 170 180 LELAQGIVAA RPASRVLLVA AEALSLRCNW KDRTTCVLFG DGAGATVVTA DVDATQGTAV 190 200 210 220 230 240 LEDSIVTSDG SLGDLLTIGG GTANPYAIGD SVGEEYFVRM QGRDVFKHAV RSMTQVCNDL 250 260 270 280 290 300 LARNGFTTED VDLVIPHQAN LRIIEAVGDR LGFASEKVFV NVHDFGNTSA ASIPLALADA 310 320 330 RAQGRIRPGM RVLLTTFGGG FTWGAALLRF

References

[1]

"Contribution of mobile genetic elements to Desulfovibrio vulgaris genome plasticity." Walker C.B., Stolyar S., Chivian D., Pinel N., Gabster J.A., Dehal P.S., He Z., Yang Z.K., Yen H.C., Zhou J., Wall J.D., Hazen T.C., Arkin A.P., Stahl D.A. Environ. Microbiol. 11:2244-2252(2009) [PubMed: 19737303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DP4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000527 Genomic DNA. Translation: ABM28867.1.
RefSeq	YP_967294.1. NC_008751.1.
3D structure databases
ProteinModelPortal	A1VEK1.
ModBase	Search...
Protein-protein interaction databases
STRING	A1VEK1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4662350.
GenomeReviews	Gene locus Dvul_1850 in contig CP000527_GR.
KEGG	dvl:Dvul_1850.
PATRIC	21767582. VBIDesVul62463_2064.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0332.
HOGENOM	HBG649927.
OMA	QANTRIV.
PhylomeDB	A1VEK1.
ProtClustDB	CLSK705098.
Family and domain databases
HAMAP	MF_01815. FabH. [Tree]
InterPro	IPR013751. ACP_syn_III. IPR013747. ACP_syn_III_C. IPR004655. FabH_synth. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. [Graphical view]
Gene3D	G3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KO	K00648.
Pfam	PF08545. ACP_syn_III. 1 hit. PF08541. ACP_syn_III_C. 1 hit. [Graphical view]
SUPFAM	SSF53901. Thiolase-like. 1 hit.
TIGRFAMs	TIGR00747. FabH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FABH_DESVV

Accession

Primary (citable) accession number: A1VEK1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program