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A1VE02

- GCSPA_DESVV

UniProt

A1VE02 - GCSPA_DESVV

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 1
Gene
gcvPA, Dvul_1651
Organism
Desulfovibrio vulgaris subsp. vulgaris (strain DP4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciDVUL391774:GHS0-1706-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:Dvul_1651
OrganismiDesulfovibrio vulgaris subsp. vulgaris (strain DP4)
Taxonomic identifieri391774 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000009173: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation
PRO_1000045647Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi391774.Dvul_1651.

Structurei

3D structure databases

ProteinModelPortaliA1VE02.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A1VE02-1 [UniParc]FASTAAdd to Basket

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MPFVPHSPED VSVMLDAIGV NTIEDLFADI PAEMRPKSFA LPKGLSEMDV    50
CSRLEALSAR NRTDVVSFLG AGFYDHHIPK AVDALSSRGE FYTAYTPYQP 100
EAAQGTLQAI FEFQTAVCRL LDMDCANASV YDGGSALFEA MMMAVRATRR 150
RKLVIDEALS PIYRTMLASY TSNLQLELVT VPHRDGLPDM DALKASVDDT 200
CAAVVVQNPN FFGAITDFTD LFTHARAHKA LGVISVYPVM QSVLKTPGEM 250
GADIAVADGQ SIGQPLSFGG PYLGIMTCTK PLVRQIPGRI VGRTQDVDGR 300
TGYVLTLQAR EQHIRRAKAT SNICSNQALC ALRSLIHLTL LGPEGLVRTA 350
ELSMERARYA AERLTALPGV ELLHDAPFGN EFAVRLPVSA FEVVDRLTAR 400
GYVPGFPVGR YYPGMDNVLL VACTEKHSFE QVGILAEMLG GIL 443
Length:443
Mass (Da):48,162
Last modified:February 6, 2007 - v1
Checksum:i1A99219C7C099AE6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000527 Genomic DNA. Translation: ABM28668.1.
RefSeqiYP_967095.1. NC_008751.1.

Genome annotation databases

EnsemblBacteriaiABM28668; ABM28668; Dvul_1651.
GeneIDi4663806.
KEGGidvl:Dvul_1651.
PATRICi21767171. VBIDesVul62463_1861.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000527 Genomic DNA. Translation: ABM28668.1 .
RefSeqi YP_967095.1. NC_008751.1.

3D structure databases

ProteinModelPortali A1VE02.
ModBasei Search...

Protein-protein interaction databases

STRINGi 391774.Dvul_1651.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM28668 ; ABM28668 ; Dvul_1651 .
GeneIDi 4663806.
KEGGi dvl:Dvul_1651.
PATRICi 21767171. VBIDesVul62463_1861.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci DVUL391774:GHS0-1706-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DP4.

Entry informationi

Entry nameiGCSPA_DESVV
AccessioniPrimary (citable) accession number: A1VE02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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