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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Desulfovibrio vulgaris subsp. vulgaris (strain DP4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Dvul_1651
OrganismiDesulfovibrio vulgaris subsp. vulgaris (strain DP4)
Taxonomic identifieri391774 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000009173 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000456471 – 443Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST443

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA1VE02
SMRiA1VE02
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

A1VE02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFVPHSPED VSVMLDAIGV NTIEDLFADI PAEMRPKSFA LPKGLSEMDV
60 70 80 90 100
CSRLEALSAR NRTDVVSFLG AGFYDHHIPK AVDALSSRGE FYTAYTPYQP
110 120 130 140 150
EAAQGTLQAI FEFQTAVCRL LDMDCANASV YDGGSALFEA MMMAVRATRR
160 170 180 190 200
RKLVIDEALS PIYRTMLASY TSNLQLELVT VPHRDGLPDM DALKASVDDT
210 220 230 240 250
CAAVVVQNPN FFGAITDFTD LFTHARAHKA LGVISVYPVM QSVLKTPGEM
260 270 280 290 300
GADIAVADGQ SIGQPLSFGG PYLGIMTCTK PLVRQIPGRI VGRTQDVDGR
310 320 330 340 350
TGYVLTLQAR EQHIRRAKAT SNICSNQALC ALRSLIHLTL LGPEGLVRTA
360 370 380 390 400
ELSMERARYA AERLTALPGV ELLHDAPFGN EFAVRLPVSA FEVVDRLTAR
410 420 430 440
GYVPGFPVGR YYPGMDNVLL VACTEKHSFE QVGILAEMLG GIL
Length:443
Mass (Da):48,162
Last modified:February 6, 2007 - v1
Checksum:i1A99219C7C099AE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000527 Genomic DNA Translation: ABM28668.1
RefSeqiWP_011792394.1, NC_008751.1

Genome annotation databases

EnsemblBacteriaiABM28668; ABM28668; Dvul_1651
KEGGidvl:Dvul_1651

Similar proteinsi

Entry informationi

Entry nameiGCSPA_DESVV
AccessioniPrimary (citable) accession number: A1VE02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: April 25, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health