A1VDL1 (KDSA_DESVV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-dehydro-3-deoxyphosphooctonate aldolase
EC=2.5.1.55

Alternative name(s):
3-deoxy-D-manno-octulosonic acid 8-phosphate synthase
KDO-8-phosphate synthase
Short name=KDO 8-P synthase
Short name=KDOPS
Phospho-2-dehydro-3-deoxyoctonate aldolase

Gene names

Name:	kdsA
Ordered Locus Names:	Dvul_1510

Organism

Desulfovibrio vulgaris subsp. vulgaris (strain DP4) [Complete proteome] [HAMAP]

Taxonomic identifier

391774 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate. HAMAP MF_00056
Pathway	Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3. HAMAP MF_00056 Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP MF_00056
Subcellular location	Cytoplasm By similarity HAMAP MF_00056.
Sequence similarities	Belongs to the KdsA family.

Ontologies

Keywords
Biological process	Lipopolysaccharide biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipopolysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-deoxy-8-phosphooctulonate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 273	273	2-dehydro-3-deoxyphosphooctonate aldolase HAMAP MF_00056		PRO_0000304447

Sequences

	Sequence		Length	Mass (Da)
	A1VDL1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 2FBC2EB503DBD677	FASTA	273	29,368
	10 20 30 40 50 60 MQHPTPDALH ARLAARRFIL AGPCALEDFD VAMETAHAVR EAAEAAGLFA VFKSSWDKAN 70 80 90 100 110 120 RTSITSFRGP GLVRGMEWLA RIREESGLPV VTDIHLPEQA APVAEVADII QIPAFLCRQT 130 140 150 160 170 180 DLLVAAAATG RVVNVKKGQF VAPWDMRPAV EKLRAAGNER ILLTERGTSF GYNNLVVDYR 190 200 210 220 230 240 SIPTMQGFGV PVVFDATHSV QLPGGLGGSS GGERRHVPVL ARAAVAAGVD GVFLECHPDP 250 260 270 DKALCDGPNS WPLDRLPALL KELSALWSLE HVC

References

[1]

"Contribution of mobile genetic elements to Desulfovibrio vulgaris genome plasticity." Walker C.B., Stolyar S., Chivian D., Pinel N., Gabster J.A., Dehal P.S., He Z., Yang Z.K., Yen H.C., Zhou J., Wall J.D., Hazen T.C., Arkin A.P., Stahl D.A. Environ. Microbiol. 11:2244-2252(2009) [PubMed: 19737303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DP4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000527 Genomic DNA. Translation: ABM28527.1.
RefSeq	YP_966954.1. NC_008751.1.
3D structure databases
ProteinModelPortal	A1VDL1.
SMR	A1VDL1. Positions 16-268.
ModBase	Search...
Protein-protein interaction databases
STRING	A1VDL1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4662119.
GenomeReviews	Gene locus Dvul_1510 in contig CP000527_GR.
KEGG	dvl:Dvul_1510.
NMPDR	fig|391774.5.peg.1522.
PATRIC	21766867. VBIDesVul62463_1715.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2877.
HOGENOM	HBG575990.
OMA	HENEQCA.
PhylomeDB	A1VDL1.
ProtClustDB	PRK05198.
Family and domain databases
HAMAP	MF_00056. KDO8P_synth. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006269. KDO8P_synthase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01627.
PANTHER	PTHR21057:SF2. KDO8P_synthase. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01362. KDO8P_synth. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KDSA_DESVV

Accession

Primary (citable) accession number: A1VDL1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	February 6, 2007
Last modified:	January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program