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A1VC42

- RUVC_DESVV

UniProt

A1VC42 - RUVC_DESVV

Protein

Crossover junction endodeoxyribonuclease RuvC

Gene

ruvC

Organism
Desulfovibrio vulgaris subsp. vulgaris (strain DP4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.UniRule annotation

    Catalytic activityi

    Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi11 – 111MagnesiumUniRule annotation
    Metal bindingi70 – 701MagnesiumUniRule annotation
    Metal bindingi142 – 1421MagnesiumUniRule annotation
    Metal bindingi145 – 1451MagnesiumUniRule annotation

    GO - Molecular functioni

    1. crossover junction endodeoxyribonuclease activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. DNA recombination Source: UniProtKB-HAMAP
    2. DNA repair Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase, Nuclease

    Keywords - Biological processi

    DNA damage, DNA recombination, DNA repair

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciDVUL391774:GHS0-1021-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Crossover junction endodeoxyribonuclease RuvCUniRule annotation (EC:3.1.22.4UniRule annotation)
    Alternative name(s):
    Holliday junction nuclease RuvCUniRule annotation
    Holliday junction resolvase RuvCUniRule annotation
    Gene namesi
    Name:ruvCUniRule annotation
    Ordered Locus Names:Dvul_0987
    OrganismiDesulfovibrio vulgaris subsp. vulgaris (strain DP4)
    Taxonomic identifieri391774 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
    ProteomesiUP000009173: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 166166Crossover junction endodeoxyribonuclease RuvCPRO_1000002749Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi391774.Dvul_0987.

    Structurei

    3D structure databases

    ProteinModelPortaliA1VC42.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RuvC family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0817.
    HOGENOMiHOG000012181.
    KOiK01159.
    OMAiMQIKLAL.
    OrthoDBiEOG6RG044.

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    HAMAPiMF_00034. RuvC.
    InterProiIPR012337. RNaseH-like_dom.
    IPR002176. X-over_junc_endoDNase_RuvC.
    [Graphical view]
    PfamiPF02075. RuvC. 1 hit.
    [Graphical view]
    PRINTSiPR00696. RSOLVASERUVC.
    SUPFAMiSSF53098. SSF53098. 1 hit.
    TIGRFAMsiTIGR00228. ruvC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1VC42-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAASVTVIGI DPGSQCTGWG IVREASGVLT LVNCGAIRPK GADFAARLGD    50
    LYRQLADVVR AHTPDEAAVE DVHAAQNVAT ALKLGQARGV VVAACAAHGV 100
    PVIDYRPSVI KKALVGTGRA EKEQVGYMVG QVLGVRPDWK LDTGDALAAA 150
    ICHLNQRRLT RLAGLA 166
    Length:166
    Mass (Da):17,258
    Last modified:February 6, 2007 - v1
    Checksum:iD212E24B6458E968
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000527 Genomic DNA. Translation: ABM28008.1.
    RefSeqiYP_966435.1. NC_008751.1.

    Genome annotation databases

    EnsemblBacteriaiABM28008; ABM28008; Dvul_0987.
    GeneIDi4662684.
    KEGGidvl:Dvul_0987.
    PATRICi21765757. VBIDesVul62463_1173.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000527 Genomic DNA. Translation: ABM28008.1 .
    RefSeqi YP_966435.1. NC_008751.1.

    3D structure databases

    ProteinModelPortali A1VC42.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391774.Dvul_0987.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM28008 ; ABM28008 ; Dvul_0987 .
    GeneIDi 4662684.
    KEGGi dvl:Dvul_0987.
    PATRICi 21765757. VBIDesVul62463_1173.

    Phylogenomic databases

    eggNOGi COG0817.
    HOGENOMi HOG000012181.
    KOi K01159.
    OMAi MQIKLAL.
    OrthoDBi EOG6RG044.

    Enzyme and pathway databases

    BioCyci DVUL391774:GHS0-1021-MONOMER.

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    HAMAPi MF_00034. RuvC.
    InterProi IPR012337. RNaseH-like_dom.
    IPR002176. X-over_junc_endoDNase_RuvC.
    [Graphical view ]
    Pfami PF02075. RuvC. 1 hit.
    [Graphical view ]
    PRINTSi PR00696. RSOLVASERUVC.
    SUPFAMi SSF53098. SSF53098. 1 hit.
    TIGRFAMsi TIGR00228. ruvC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DP4.

    Entry informationi

    Entry nameiRUVC_DESVV
    AccessioniPrimary (citable) accession number: A1VC42
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3