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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Desulfovibrio vulgaris subsp. vulgaris (strain DP4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

Cofactori

FADUniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 16FADUniRule annotation6

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
Gene namesi
Name:trmFOUniRule annotation
Ordered Locus Names:Dvul_0911
OrganismiDesulfovibrio vulgaris subsp. vulgaris (strain DP4)
Taxonomic identifieri391774 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000009173 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003463371 – 482Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOAdd BLAST482

Structurei

3D structure databases

ProteinModelPortaliA1VBW6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000252054.
KOiK04094.
OMAiDYLNCPM.

Family and domain databases

Gene3Di3.40.50.720. 3 hits.
3.50.50.60. 1 hit.
HAMAPiMF_01037. TrmFO. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR002218. MnmG-rel.
IPR016040. NAD(P)-bd_dom.
IPR004417. TrmFO.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.

Sequencei

Sequence statusi: Complete.

A1VBW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTITTAAII GAGLAGCECA LRLARAGVRV TLFEMKPAAF SPAHSNPDLG
60 70 80 90 100
ELVCSNSLRS DDIASGVGLL KQEMRELGSI VMEAADATRV PAGKALAVDR
110 120 130 140 150
DLFARHITAV IEAEPGITLE RREVASLDDP ALASADVVVV AAGPLASAGL
160 170 180 190 200
SDSLAAMVGG QLYFYDAIAP IIAAESIDLS IAFSGSRYGE PGEEGDYLNC
210 220 230 240 250
PMNRDEYDAF YEALLAAEKV PSRDFEKELH FEGCMPIEAL AERGPRTLVF
260 270 280 290 300
GPFKPVGFTD PRTGTRPYAI IQLRAENRNK TAFNIVGCQT KLKYAEQERV
310 320 330 340 350
FRMIPGLAGA EFVRHGSVHR NTYVNAPRVL ADDLSLRADK RVFLAGQITG
360 370 380 390 400
VEGYVESAAC GMWLGMVLAA RIQGRELPTP PPQTALGALL MHLRTPVKNF
410 420 430 440 450
QPSNANFGLM PELGLKVKKR ERKPLYSARA REHFVRWLAE AGVTPVIEPL
460 470 480
LPTAPDAADA TGAIDTTGAT GAAREETAPT EA
Length:482
Mass (Da):51,560
Last modified:February 6, 2007 - v1
Checksum:i9495F7E5D1617041
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000527 Genomic DNA. Translation: ABM27932.1.
RefSeqiWP_011791925.1. NC_008751.1.

Genome annotation databases

EnsemblBacteriaiABM27932; ABM27932; Dvul_0911.
KEGGidvl:Dvul_0911.
PATRICi21765599. VBIDesVul62463_1095.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000527 Genomic DNA. Translation: ABM27932.1.
RefSeqiWP_011791925.1. NC_008751.1.

3D structure databases

ProteinModelPortaliA1VBW6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM27932; ABM27932; Dvul_0911.
KEGGidvl:Dvul_0911.
PATRICi21765599. VBIDesVul62463_1095.

Phylogenomic databases

HOGENOMiHOG000252054.
KOiK04094.
OMAiDYLNCPM.

Family and domain databases

Gene3Di3.40.50.720. 3 hits.
3.50.50.60. 1 hit.
HAMAPiMF_01037. TrmFO. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR002218. MnmG-rel.
IPR016040. NAD(P)-bd_dom.
IPR004417. TrmFO.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRMFO_DESVV
AccessioniPrimary (citable) accession number: A1VBW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: February 6, 2007
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.