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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Desulfovibrio vulgaris subsp. vulgaris (strain DP4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

Cofactori

FADUniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 16FADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandFAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
Gene namesi
Name:trmFOUniRule annotation
Ordered Locus Names:Dvul_0911
OrganismiDesulfovibrio vulgaris subsp. vulgaris (strain DP4)
Taxonomic identifieri391774 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000009173 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003463371 – 482Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOAdd BLAST482

Proteomic databases

PRIDEiA1VBW6

Structurei

3D structure databases

ProteinModelPortaliA1VBW6
SMRiA1VBW6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000252054
KOiK04094
OMAiRFGPMKP

Family and domain databases

Gene3Di3.50.50.60, 2 hits
HAMAPiMF_01037 TrmFO, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR002218 MnmG-rel
IPR004417 TrmFO
PANTHERiPTHR11806 PTHR11806, 1 hit
PTHR11806:SF2 PTHR11806:SF2, 1 hit
PfamiView protein in Pfam
PF01134 GIDA, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR00137 gid_trmFO, 1 hit

Sequencei

Sequence statusi: Complete.

A1VBW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTITTAAII GAGLAGCECA LRLARAGVRV TLFEMKPAAF SPAHSNPDLG
60 70 80 90 100
ELVCSNSLRS DDIASGVGLL KQEMRELGSI VMEAADATRV PAGKALAVDR
110 120 130 140 150
DLFARHITAV IEAEPGITLE RREVASLDDP ALASADVVVV AAGPLASAGL
160 170 180 190 200
SDSLAAMVGG QLYFYDAIAP IIAAESIDLS IAFSGSRYGE PGEEGDYLNC
210 220 230 240 250
PMNRDEYDAF YEALLAAEKV PSRDFEKELH FEGCMPIEAL AERGPRTLVF
260 270 280 290 300
GPFKPVGFTD PRTGTRPYAI IQLRAENRNK TAFNIVGCQT KLKYAEQERV
310 320 330 340 350
FRMIPGLAGA EFVRHGSVHR NTYVNAPRVL ADDLSLRADK RVFLAGQITG
360 370 380 390 400
VEGYVESAAC GMWLGMVLAA RIQGRELPTP PPQTALGALL MHLRTPVKNF
410 420 430 440 450
QPSNANFGLM PELGLKVKKR ERKPLYSARA REHFVRWLAE AGVTPVIEPL
460 470 480
LPTAPDAADA TGAIDTTGAT GAAREETAPT EA
Length:482
Mass (Da):51,560
Last modified:February 6, 2007 - v1
Checksum:i9495F7E5D1617041
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000527 Genomic DNA Translation: ABM27932.1
RefSeqiWP_011791925.1, NC_008751.1

Genome annotation databases

EnsemblBacteriaiABM27932; ABM27932; Dvul_0911
KEGGidvl:Dvul_0911

Similar proteinsi

Entry informationi

Entry nameiTRMFO_DESVV
AccessioniPrimary (citable) accession number: A1VBW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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