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Protein

Acetate kinase

Gene

ackA

Organism
Desulfovibrio vulgaris subsp. vulgaris (strain DP4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (Dvul_0344)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7MagnesiumUniRule annotation1
Binding sitei14ATPUniRule annotation1
Binding sitei95SubstrateUniRule annotation1
Active sitei152Proton donor/acceptorUniRule annotation1
Sitei184Transition state stabilizerUniRule annotation1
Sitei245Transition state stabilizerUniRule annotation1
Metal bindingi388MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi212 – 216ATPUniRule annotation5
Nucleotide bindingi286 – 288ATPUniRule annotation3
Nucleotide bindingi334 – 338ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:Dvul_0343
OrganismiDesulfovibrio vulgaris subsp. vulgaris (strain DP4)
Taxonomic identifieri391774 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000009173 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000022301 – 402Acetate kinaseAdd BLAST402

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA1VAA0.
SMRiA1VAA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000288398.
KOiK00925.
OMAiWKALTGT.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
InterProiView protein in InterPro
IPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiView protein in Pfam
PF00871. Acetate_kinase. 1 hit.
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiView protein in PROSITE
PS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A1VAA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVLVINSGS SSIKYQLIDM EREVPLCSGL VERIGEPMGK LTHKIRPDAE
60 70 80 90 100
GEEKLTFEQP FTNHVEGMKR VVELITDADK GVIKDKSEIG AIGHRVLLGG
110 120 130 140 150
EEIKQSVRID DWAKGVIRDY IPLGPLHNPA NLAGIEVAEE LFPGLPNVGV
160 170 180 190 200
FDTEFHQSMP AKAYLYPLPI ELYEELKIRR YGFHGTSHRY ITKRTAQYLG
210 220 230 240 250
KPLDELNIIT CHLGNGCSMA AVKNGKCVDT TMGITPLEGL MMGTRCGDID
260 270 280 290 300
PAIVPFLMEK KNLSPAEADT LMNKQSGLKG VCGMNDMRDL HAARENGNER
310 320 330 340 350
AQLAFEMFTY RIKKYIGAYY AVLGRVDAVV FTAGIGENDD FVRAEVCAGL
360 370 380 390 400
DSLGIAVDPA RNAVRNGQPR HISPDGSRVA VLVVPTNEEL EIAQATLDVL

KG
Length:402
Mass (Da):44,104
Last modified:February 6, 2007 - v1
Checksum:i3EF1D601CB4E62F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000527 Genomic DNA. Translation: ABM27366.1.
RefSeqiWP_011791553.1. NC_008751.1.

Genome annotation databases

EnsemblBacteriaiABM27366; ABM27366; Dvul_0343.
KEGGidvl:Dvul_0343.

Similar proteinsi

Entry informationi

Entry nameiACKA_DESVV
AccessioniPrimary (citable) accession number: A1VAA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: June 7, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families