Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycerol kinase

Gene

glpK

Organism
Desulfovibrio vulgaris subsp. vulgaris (strain DP4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.UniRule annotation

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotation

Enzyme regulationi

Inhibited by fructose 1,6-bisphosphate (FBP).UniRule annotation

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Glycerol kinase (glpK)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol, the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei12 – 121SubstrateUniRule annotation
Binding sitei16 – 161ATPUniRule annotation
Binding sitei134 – 1341SubstrateUniRule annotation
Binding sitei265 – 2651ATPUniRule annotation
Binding sitei308 – 3081ATP; via carbonyl oxygenUniRule annotation
Binding sitei312 – 3121ATP; via amide nitrogenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 143ATPUniRule annotation
Nucleotide bindingi409 – 4135ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycerol metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDVUL391774:GHS0-256-MONOMER.
UniPathwayiUPA00618; UER00672.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinaseUniRule annotation (EC:2.7.1.30UniRule annotation)
Alternative name(s):
ATP:glycerol 3-phosphotransferaseUniRule annotation
GlycerokinaseUniRule annotation
Short name:
GKUniRule annotation
Gene namesi
Name:glpKUniRule annotation
Ordered Locus Names:Dvul_0252
OrganismiDesulfovibrio vulgaris subsp. vulgaris (strain DP4)
Taxonomic identifieri391774 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000009173 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Glycerol kinasePRO_1000020728Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA1VA10.
SMRiA1VA10. Positions 2-497.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni82 – 832Substrate bindingUniRule annotation
Regioni243 – 2442Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the FGGY kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000222134.
KOiK00864.
OMAiPMEIFAT.

Family and domain databases

HAMAPiMF_00186. Glycerol_kin. 1 hit.
InterProiIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000538. GlpK. 1 hit.
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1VA10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNYVLALDQ GTTSSRAILF TREGDIKQIS QKEFTQIYPQ PGWVEHNANE
60 70 80 90 100
IFDTQSWVMR ECLQEAGIGA ADVVAAGITN QRETTVVWDK ATGAPVYNAI
110 120 130 140 150
VWQDRRTAGF CDELKARGLA DVFRKKTGLV LDAYFSGTKV RWILDNVPGA
160 170 180 190 200
RAKAEKGELL FGTIDTWLIW NLTKGKAHVT DSSNASRTLM FNINTGAWDD
210 220 230 240 250
ELLGILDVPR SMLPRVTGSS EVVGDIHPEF LGKAIPIAGN AGDQQAATYG
260 270 280 290 300
NACLKPGMAK NTYGTGCFML MNTGTEVRSS QNNLLSTVAW TTPSGRFYAL
310 320 330 340 350
EGSVFIAGAV VQWLRDGLGI IKAAPEVEQL ALSVPDNGGV YLVPAFAGLG
360 370 380 390 400
APHWDQYARG TMVGITRGAT KAHIARAALE SIALQTLDIM DCMQKDSGIK
410 420 430 440 450
LAALRADGGA TRNNLLMQFQ ADVLGVPVER PKVTETTALG AAYLAGLATG
460 470 480 490
FWKSEDEIAT MWQLDRRFEP NMSDDKRQHL VYEWQRAVER AKAWVEA
Length:497
Mass (Da):54,199
Last modified:February 6, 2007 - v1
Checksum:iE481956135B05525
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000527 Genomic DNA. Translation: ABM27276.1.
RefSeqiWP_010940392.1. NC_008751.1.

Genome annotation databases

EnsemblBacteriaiABM27276; ABM27276; Dvul_0252.
KEGGidvl:Dvul_0252.
PATRICi21764165. VBIDesVul62463_0408.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000527 Genomic DNA. Translation: ABM27276.1.
RefSeqiWP_010940392.1. NC_008751.1.

3D structure databases

ProteinModelPortaliA1VA10.
SMRiA1VA10. Positions 2-497.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM27276; ABM27276; Dvul_0252.
KEGGidvl:Dvul_0252.
PATRICi21764165. VBIDesVul62463_0408.

Phylogenomic databases

HOGENOMiHOG000222134.
KOiK00864.
OMAiPMEIFAT.

Enzyme and pathway databases

UniPathwayiUPA00618; UER00672.
BioCyciDVUL391774:GHS0-256-MONOMER.

Family and domain databases

HAMAPiMF_00186. Glycerol_kin. 1 hit.
InterProiIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000538. GlpK. 1 hit.
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLPK_DESVV
AccessioniPrimary (citable) accession number: A1VA10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: September 7, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.