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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Desulfovibrio vulgaris subsp. vulgaris (strain DP4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:Dvul_0030
OrganismiDesulfovibrio vulgaris subsp. vulgaris (strain DP4)
Taxonomic identifieri391774 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000009173 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000200541 – 330Methionyl-tRNA formyltransferaseAdd BLAST330

Structurei

3D structure databases

ProteinModelPortaliA1V9B4.
SMRiA1V9B4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni116 – 119Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000261177.
KOiK00604.
OMAiLRIVFMG.

Family and domain databases

Gene3Di3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPiMF_00182. Formyl_trans. 1 hit.
InterProiView protein in InterPro
IPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
PfamiView protein in Pfam
PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
SUPFAMiSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00460. fmt. 1 hit.
PROSITEiView protein in PROSITE
PS00373. GART. 1 hit.

Sequencei

Sequence statusi: Complete.

A1V9B4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESAPLKIV FMGTPDFAAA SLRHLLAWDG CDVVGVYTQP DRPCGRGQQC
60 70 80 90 100
RPSAVKMLAL EHGLDVRQPV NFRDEADVQA LRDFGADILV VAAYGLILPQ
110 120 130 140 150
SVLDAAPMGA VNVHGSLLPR YRGAAPIQRA VMNGDAVTGI TIMQVVKQLD
160 170 180 190 200
AGPMLLQKAL GIGCDETSGQ LHDQLAELGG RLLVETLARL RAGTIMPIPQ
210 220 230 240 250
DDALATYAAK LTKADGLVDW NRTAVEVHAQ VRGVTPWPAA YFTLRREGQK
260 270 280 290 300
DVRVTIEPGT IGPLLEQPAV PGTIVGLVDG AIAFACADRT YLVRTIRPAD
310 320 330
KKPMTGEAFW CGYLSRCEGE CPGFAVCEGA
Length:330
Mass (Da):35,224
Last modified:February 6, 2007 - v1
Checksum:iF39C4FD13D85ECC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000527 Genomic DNA. Translation: ABM27054.1.
RefSeqiWP_011791337.1. NC_008751.1.

Genome annotation databases

EnsemblBacteriaiABM27054; ABM27054; Dvul_0030.
KEGGidvl:Dvul_0030.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFMT_DESVV
AccessioniPrimary (citable) accession number: A1V9B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: June 7, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families