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A1V6V5

- DUT_BURMS

UniProt

A1V6V5 - DUT_BURMS

Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

dut

Organism
Burkholderia mallei (strain SAVP1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.UniRule annotation

    Catalytic activityi

    dUTP + H2O = dUMP + diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei80 – 801SubstrateUniRule annotation
    Binding sitei94 – 941Substrate; via amide nitrogen and carbonyl oxygenUniRule annotation

    GO - Molecular functioni

    1. dUTP diphosphatase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dUMP biosynthetic process Source: UniProtKB-UniPathway
    2. dUTP metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciBMAL320388:GHFL-2660-MONOMER.
    UniPathwayiUPA00610; UER00666.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
    Short name:
    dUTPaseUniRule annotation
    Alternative name(s):
    dUTP pyrophosphataseUniRule annotation
    Gene namesi
    Name:dutUniRule annotation
    Ordered Locus Names:BMASAVP1_A2661
    OrganismiBurkholderia mallei (strain SAVP1)
    Taxonomic identifieri320388 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000006708: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 148148Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_1000015454Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi320388.BMASAVP1_A2661.

    Structurei

    3D structure databases

    ProteinModelPortaliA1V6V5.
    SMRiA1V6V5. Positions 2-132.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni67 – 693Substrate bindingUniRule annotation
    Regioni84 – 863Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the dUTPase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0756.
    HOGENOMiHOG000028968.
    KOiK01520.
    OMAiFERFDRI.
    OrthoDBiEOG689HXK.

    Family and domain databases

    Gene3Di2.70.40.10. 1 hit.
    HAMAPiMF_00116. dUTPase_bact.
    InterProiIPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view]
    PfamiPF00692. dUTPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51283. SSF51283. 1 hit.
    TIGRFAMsiTIGR00576. dut. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1V6V5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLDLKILDA RMRDYLPKYA TTGSAGLDLR ACLDAPVTLK PGDTALVPTG    50
    LAIHLADPGY AALILPRSGL GHKHGIVLGN LVGLIDSDYQ GELMISTWNR 100
    GQTEFALNPF ERLAQLVIVP VVQARFNLVD DFAQSERGAG GFGSTGRG 148
    Length:148
    Mass (Da):15,802
    Last modified:February 6, 2007 - v1
    Checksum:i7701824C804B54A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000526 Genomic DNA. Translation: ABM49645.1.
    RefSeqiYP_993958.1. NC_008785.1.

    Genome annotation databases

    EnsemblBacteriaiABM49645; ABM49645; BMASAVP1_A2661.
    GeneIDi4681537.
    KEGGibmv:BMASAVP1_A2661.
    PATRICi19158039. VBIBurMal134057_4254.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000526 Genomic DNA. Translation: ABM49645.1 .
    RefSeqi YP_993958.1. NC_008785.1.

    3D structure databases

    ProteinModelPortali A1V6V5.
    SMRi A1V6V5. Positions 2-132.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 320388.BMASAVP1_A2661.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM49645 ; ABM49645 ; BMASAVP1_A2661 .
    GeneIDi 4681537.
    KEGGi bmv:BMASAVP1_A2661.
    PATRICi 19158039. VBIBurMal134057_4254.

    Phylogenomic databases

    eggNOGi COG0756.
    HOGENOMi HOG000028968.
    KOi K01520.
    OMAi FERFDRI.
    OrthoDBi EOG689HXK.

    Enzyme and pathway databases

    UniPathwayi UPA00610 ; UER00666 .
    BioCyci BMAL320388:GHFL-2660-MONOMER.

    Family and domain databases

    Gene3Di 2.70.40.10. 1 hit.
    HAMAPi MF_00116. dUTPase_bact.
    InterProi IPR029054. dUTPase-like.
    IPR008180. dUTPase/dCTP_deaminase.
    IPR008181. dUTPase_1.
    [Graphical view ]
    Pfami PF00692. dUTPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51283. SSF51283. 1 hit.
    TIGRFAMsi TIGR00576. dut. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. DeShazer D., Woods D.E., Nierman W.C.
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SAVP1.

    Entry informationi

    Entry nameiDUT_BURMS
    AccessioniPrimary (citable) accession number: A1V6V5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3