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A1V4V3 (A1V4V3_BURMS) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine synthase HAMAP-Rule MF_00419
Short name=FGAM synthase HAMAP-Rule MF_00419
Short name=FGAMS HAMAP-Rule MF_00419
EC=6.3.5.3 HAMAP-Rule MF_00419
Alternative name(s):
Formylglycinamide ribotide amidotransferase HAMAP-Rule MF_00419
Formylglycinamide ribotide synthetase HAMAP-Rule MF_00419
Gene names
Name:purL HAMAP-Rule MF_00419 EMBL ABM50877.1
Ordered Locus Names:BMASAVP1_A1937
OrganismBurkholderia mallei (strain SAVP1) [Complete proteome] [HAMAP]
Taxonomic identifier320388 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group ›

Protein attributes

Sequence length1353 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP-Rule MF_00419 SAAS SAAS022940

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP-Rule MF_00419 SAAS SAAS022940

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00419 SAAS SAAS022940

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00419.

Sequence similarities

Contains 1 glutamine amidotransferase type-1 domain. HAMAP-Rule MF_00419 SAAS SAAS022940

In the N-terminal section; belongs to the FGAMS family. HAMAP-Rule MF_00419

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain1104 – 1353250Glutamine amidotransferase type-1 By similarity HAMAP-Rule MF_00419
Nucleotide binding324 – 33512ATP By similarity HAMAP-Rule MF_00419

Sites

Active site11971Nucleophile By similarity HAMAP-Rule MF_00419
Active site13181 By similarity HAMAP-Rule MF_00419
Active site13201 By similarity HAMAP-Rule MF_00419

Sequences

Sequence LengthMass (Da)Tools
A1V4V3 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 6BAE8512F9A895E2

FASTA1,353145,231
        10         20         30         40         50         60 
MAHFSCFPGA SALSDFRQTR LLDALKQIDG DIVAVRGQYL HFVNAHEPLT ADDEARIGAL 

        70         80         90        100        110        120 
MHYGAPLEPA AEKGATETFV VLPRFGTVSP WASKATDIAR HCGLARVRRI ERGIEFTVTL 

       130        140        150        160        170        180 
KAGVLGVGAK KALAADARAA VAAALHDRMT ESVVASREDA RHLFDELPAK PLATVDVLAE 

       190        200        210        220        230        240 
GRAALERANA ELGLALADDE IDYLVDAFIK LERNPTDVEL MMFAQANSEH CRHKIFNAQW 

       250        260        270        280        290        300 
TIDGQAQDMS LFAMIRNTEK MSPQGTIVAY SDNSSIMSGA YAERWFPRGA GEPGERYGRH 

       310        320        330        340        350        360 
TELTHTLMKV ETHNHPSAIS PFPGAATGAG GEIRDEGATG RGARPKAGLT GFTVSNLDLP 

       370        380        390        400        410        420 
GARESWENAR DAAQPAAARN AQQPCAPYGR PDRIASPLSI MIDGPLGGAA FNNEFGRPNL 

       430        440        450        460        470        480 
GGYFRVYEQN VGGQVRGYHK PIMIAGGIGN ISDAHTHKHD VPAGSLLIQI GGPGMRIGMG 

       490        500        510        520        530        540 
GGAASSMATG ANTAELDFDS VQRGNPEIER RAQEVINGCW QLGEHNPILS IHDVGAGGLS 

       550        560        570        580        590        600 
NAFPEIVDGA GKGARFELRK IALEESGLSP REIWSNEAQE RYVLAISPAD LPRFEAICAR 

       610        620        630        640        650        660 
ERCPFSVVGV ATDERRLQLV DGEATGAAAY PVDMPMEVLL GKPPRMHRDV KRVHIERAGV 

       670        680        690        700        710        720 
DVTGVALADA ARDVLRHPTV ASKSFLITIG DRTVGGTSVR DQMVGPWQVP VADCAVTALD 

       730        740        750        760        770        780 
YAGFAGEAMT MAERTPLAVI DAPASGRMAV GEAITNIAAA PIASLDKLKL SANWMAACGT 

       790        800        810        820        830        840 
EGEDAKLFDT VKAIGMELCP ALGIGIPVGK DSLSMKTKWN DNGVAKEVVA PVSLIISAFA 

       850        860        870        880        890        900 
PVEDVRRHLT PQLRRVADVG ASVLIAIDLG RGKNRLGGSI LAQVTQQVGD ATPDVDDPED 

       910        920        930        940        950        960 
LKRFFAAVQS LNARDLLLAY HDRSDGGLWA TVCEMALAGH AGVSLNVDML TLDQQHESDY 

       970        980        990       1000       1010       1020 
GDAKDWAKQT SGRREDRTIR ALFSEELGAV VQVRAADRDA VLGALREHGL SACSHVIGAV 

      1030       1040       1050       1060       1070       1080 
NETDAIEVYR DAKKIYEAPR VELQRAWSEV SWRIARLRDN PACADAEYDA ILDAGDPGLS 

      1090       1100       1110       1120       1130       1140 
PVLTFDPAED VAAPFIATGA RPRVAILREQ GVNSHLETAY AFDRAGFDAH DVHMSDLLAG 

      1150       1160       1170       1180       1190       1200 
RATLADFAGA VACGGFSYGD VLGAGEGWAK TIRFNDKLAD MFAAFFARPD TFALGICNGC 

      1210       1220       1230       1240       1250       1260 
QMMSSLASMI PGAQAWPKFT RNKSEQFEAR FSFVEVQSSP SIFFAGMEGS RIPVAVAHGE 

      1270       1280       1290       1300       1310       1320 
GYADFSQQGD QSRVAVAMRY VDHRGDATER YPFNPNGSPA GITSVTTADG RFTVLMPHME 

      1330       1340       1350 
RVHRTVTMSW HPQGWGEASP WLRVFRNARR WIG

« Hide

References

[1]DeShazer D., Woods D.E., Nierman W.C.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SAVP1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000526 Genomic DNA. Translation: ABM50877.1.
RefSeqYP_993256.1. NC_008785.1.

3D structure databases

ProteinModelPortalA1V4V3.
ModBaseSearch...

Protein-protein interaction databases

STRING320388.BMASAVP1_A1937.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM50877; ABM50877; BMASAVP1_A1937.
GeneID4678514.
KEGGbmv:BMASAVP1_A1937.
PATRIC19156618. VBIBurMal134057_3560.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0046.
HOGENOMHOG000261359.
KOK01952.
OMATVKAVGM.
ProtClustDBPRK05297.

Enzyme and pathway databases

BioCycBMAL320388:GHFL-1938-MONOMER.
UniPathwayUPA00074; UER00128.

Family and domain databases

HAMAPMF_00419. PurL_1.
InterProIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR017926. GATASE.
IPR010073. PRibForGlyAmidine_synth.
IPR022940. PRibForGlyAmidine_synth_bac.
IPR016188. PurM_N-like.
[Graphical view]
PfamPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 2 hits.
[Graphical view]
SUPFAMSSF56042. AIR_synth_C. 2 hits.
SSF55326. PurM_N-like. 2 hits.
TIGRFAMsTIGR01735. FGAM_synt. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA1V4V3_BURMS
AccessionPrimary (citable) accession number: A1V4V3
Entry history
Integrated into UniProtKB/TrEMBL: February 6, 2007
Last sequence update: February 6, 2007
Last modified: May 29, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info