A1V2G0 (HEM6_BURMS) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 34.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Coproporphyrinogen-III oxidase, aerobic Short name=Coprogen oxidase Short name=Coproporphyrinogenase EC=1.3.3.3 | ||||
| Gene names |
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| Organism | Burkholderia mallei (strain SAVP1) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 320388 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group |
Protein attributes
| Sequence length | 307 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity. HAMAP MF_00333 |
| Catalytic activity | Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. HAMAP MF_00333 |
| Pathway | Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. HAMAP MF_00333 |
| Subunit structure | Homodimer By similarity. HAMAP MF_00333 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00333. |
| Sequence similarities | Belongs to the aerobic coproporphyrinogen-III oxidase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Porphyrin biosynthesis |
| Cellular component | Cytoplasm |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | coproporphyrinogen oxidase activity Inferred from electronic annotation. Source: EC protein homodimerization activityInferred from sequence or structural similarity. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 307 | 307 | Coproporphyrinogen-III oxidase, aerobic HAMAP MF_00333 | PRO_1000019460 | |||||
Regions | |||||||||
| Region | 55 – 64 | 10 | Important for dimerization By similarity | ||||||
| Region | 115 – 117 | 3 | Substrate binding By similarity | ||||||
| Region | 247 – 282 | 36 | Important for dimerization By similarity | ||||||
| Region | 265 – 270 | 6 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Active site | 113 | 1 | Proton donor By similarity | ||||||
| Binding site | 99 | 1 | Substrate By similarity | ||||||
| Site | 182 | 1 | Important for dimerization By similarity | ||||||
Sequences
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References
| [1] | DeShazer D., Woods D.E., Nierman W.C. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SAVP1. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000526 Genomic DNA. Translation: ABM49971.1. |
| RefSeq | YP_992413.1. NC_008785.1. |
3D structure databases | |
| ProteinModelPortal | A1V2G0. |
| SMR | A1V2G0. Positions 5-307. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A1V2G0. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 4681476. |
| GenomeReviews | Gene locus BMASAVP1_A1073 in contig CP000526_GR. |
| KEGG | bmv:BMASAVP1_A1073. |
| PATRIC | 19154915. VBIBurMal134057_2722. |
| TIGR | BMASAVP1_A1073. |
Phylogenomic databases | |
| HOGENOM | HBG631180. |
| OMA | VKAYLLD. |
| ProtClustDB | PRK05330. |
Enzyme and pathway databases | |
| BioCyc | BMAL320388:BMASAVP1_A1073-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00333. Coprogen_oxidas. [Tree] |
| InterPro | IPR001260. Coprogen_oxidase_aer. IPR018375. Coprogen_oxidase_CS. [Graphical view] |
| Gene3D | G3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit. |
| KO | K00228. |
| PANTHER | PTHR10755. Coprogen_oxidas. 1 hit. |
| Pfam | PF01218. Coprogen_oxidas. 1 hit. [Graphical view] |
| PIRSF | PIRSF000166. Coproporphyri_ox. 1 hit. |
| PRINTS | PR00073. COPRGNOXDASE. |
| SUPFAM | SSF102886. Coprogen_oxidas. 1 hit. |
| PROSITE | PS01021. COPROGEN_OXIDASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | HEM6_BURMS | ||||||||
| Accession | Primary (citable) accession number: A1V2G0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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