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A1V1U3

- HGD_BURMS

UniProt

A1V1U3 - HGD_BURMS

Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Burkholderia mallei (strain SAVP1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

    Catalytic activityi

    Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

    Cofactori

    Iron.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei304 – 3041Proton acceptorUniRule annotation
    Metal bindingi347 – 3471IronUniRule annotation
    Metal bindingi353 – 3531IronUniRule annotation
    Binding sitei362 – 3621homogentisateUniRule annotation
    Metal bindingi383 – 3831IronUniRule annotation
    Binding sitei383 – 3831homogentisateUniRule annotation

    GO - Molecular functioni

    1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
    2. iron ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
    2. tyrosine catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Phenylalanine catabolism, Tyrosine catabolism

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciBMAL320388:GHFL-857-MONOMER.
    UniPathwayiUPA00139; UER00339.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
    Short name:
    HGDOUniRule annotation
    Alternative name(s):
    Homogentisate oxygenaseUniRule annotation
    Homogentisic acid oxidaseUniRule annotation
    HomogentisicaseUniRule annotation
    Gene namesi
    Name:hmgAUniRule annotation
    Ordered Locus Names:BMASAVP1_A0856
    OrganismiBurkholderia mallei (strain SAVP1)
    Taxonomic identifieri320388 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
    ProteomesiUP000006708: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 450450Homogentisate 1,2-dioxygenasePRO_1000019526Add
    BLAST

    Interactioni

    Subunit structurei

    Hexamer; dimer of trimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi320388.BMASAVP1_A0856.

    Structurei

    3D structure databases

    ProteinModelPortaliA1V1U3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the homogentisate dioxygenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3508.
    HOGENOMiHOG000139824.
    KOiK00451.
    OMAiRCFYNSD.
    OrthoDBiEOG6D5FZK.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    HAMAPiMF_00334. Homogentis_dioxygen.
    InterProiIPR005708. Homogentis_dOase.
    IPR022950. Homogentis_dOase_bac.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR11056. PTHR11056. 1 hit.
    PfamiPF04209. HgmA. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR01015. hmgA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1V1U3-1 [UniParc]FASTAAdd to Basket

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    MERTTIMTLD FSKPGEAGYQ SGFANEFATE ALPGALPHAR NSPQRAPYGL    50
    YAEQFSGTAF TAPRGHNRRS WLYRIRPAAV HRPFELVSGE RRIVAEFGDS 100
    DDVPPTPPNQ LRWDPLPMPA QPTDFVDGWV TMAGNGSAAA MSGCAIHLYA 150
    ANRSMRERFF YSADGELLIV PQEGRLFIMT ELGRLDVEPF EIAVIPRGVR 200
    FAVALPDGRA RGYVCENFGA LLRLPDLGPI GSNGLANPRD FLTPHASYED 250
    REGAFELVAK LNGRLWRADI DHSPFDVVAW HGNYAPYKYD LRHFNTIGSI 300
    SYDHPDPSIF LVLQSQSDTP GVDAIDFVIF PPRWLAAEDT FRPPWFHRNV 350
    ASEFMGLVHG VYDAKAEGFV PGGASLHNCM SGHGPDADTF EKASSIDTSK 400
    PNKVGDTMAF MFETRTLIRP TRFALDTAQL QANYFECWQG LKKHFNPEQR 450
    Length:450
    Mass (Da):50,130
    Last modified:February 6, 2007 - v1
    Checksum:i1BC1019C4C2C398F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000526 Genomic DNA. Translation: ABM49776.1.
    RefSeqiYP_992196.1. NC_008785.1.

    Genome annotation databases

    EnsemblBacteriaiABM49776; ABM49776; BMASAVP1_A0856.
    GeneIDi4679912.
    KEGGibmv:BMASAVP1_A0856.
    PATRICi19154464. VBIBurMal134057_2493.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000526 Genomic DNA. Translation: ABM49776.1 .
    RefSeqi YP_992196.1. NC_008785.1.

    3D structure databases

    ProteinModelPortali A1V1U3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 320388.BMASAVP1_A0856.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM49776 ; ABM49776 ; BMASAVP1_A0856 .
    GeneIDi 4679912.
    KEGGi bmv:BMASAVP1_A0856.
    PATRICi 19154464. VBIBurMal134057_2493.

    Phylogenomic databases

    eggNOGi COG3508.
    HOGENOMi HOG000139824.
    KOi K00451.
    OMAi RCFYNSD.
    OrthoDBi EOG6D5FZK.

    Enzyme and pathway databases

    UniPathwayi UPA00139 ; UER00339 .
    BioCyci BMAL320388:GHFL-857-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    HAMAPi MF_00334. Homogentis_dioxygen.
    InterProi IPR005708. Homogentis_dOase.
    IPR022950. Homogentis_dOase_bac.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR11056. PTHR11056. 1 hit.
    Pfami PF04209. HgmA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR01015. hmgA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. DeShazer D., Woods D.E., Nierman W.C.
      Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SAVP1.

    Entry informationi

    Entry nameiHGD_BURMS
    AccessioniPrimary (citable) accession number: A1V1U3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3