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Protein

RNA pyrophosphohydrolase

Gene

rppH

Organism
Burkholderia mallei (strain SAVP1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
RNA pyrophosphohydrolaseUniRule annotation (EC:3.6.1.-UniRule annotation)
Alternative name(s):
(Di)nucleoside polyphosphate hydrolaseUniRule annotation
Gene namesi
Name:rppHUniRule annotation
Synonyms:nudHUniRule annotation
Ordered Locus Names:BMASAVP1_A0440
OrganismiBurkholderia mallei (strain SAVP1)
Taxonomic identifieri320388 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000219361 – 216RNA pyrophosphohydrolaseAdd BLAST216

Structurei

3D structure databases

ProteinModelPortaliA1V0N7.
SMRiA1V0N7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 149Nudix hydrolaseUniRule annotationAdd BLAST144

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 59Nudix boxAdd BLAST22

Sequence similaritiesi

Belongs to the Nudix hydrolase family. RppH subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000066723.
KOiK08311.
OMAiRPCVGIM.

Family and domain databases

CDDicd03671. Ap4A_hydrolase_plant_like. 1 hit.
HAMAPiMF_00298. Nudix_RppH. 1 hit.
InterProiView protein in InterPro
IPR020476. Nudix_hydrolase.
IPR015797. NUDIX_hydrolase-like_dom_sf.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR022927. RppH.
PfamiView protein in Pfam
PF00293. NUDIX. 1 hit.
PRINTSiPR00502. NUDIXFAMILY.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiView protein in PROSITE
PS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.

Sequencei

Sequence statusi: Complete.

A1V0N7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDREGFRPN VGIILLNAHN EVFWGKRLRE HSWQFPQGGI KYGETPMQAM
60 70 80 90 100
YRELHEETGL LPEHVKIIGR TRDWLRYEVP DKFIKREVRG HYRGQKQIWF
110 120 130 140 150
LLRMVGRDCD ICLRATDHPE FDAWRWNEYW VPLDAVIEFK RDVYQLALTE
160 170 180 190 200
LSRFLRRPAQ RTDKSRGPRA PRYPRVANGH AASEAPAAID TSAVCSEVEP
210
GANALDETPP RVSLRD
Length:216
Mass (Da):25,263
Last modified:February 6, 2007 - v1
Checksum:iBB9E37FD1C8BA662
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000526 Genomic DNA. Translation: ABM51773.1.
RefSeqiWP_004194263.1. NC_008785.1.

Genome annotation databases

EnsemblBacteriaiABM51773; ABM51773; BMASAVP1_A0440.
KEGGibmv:BMASAVP1_A0440.

Similar proteinsi

Entry informationi

Entry nameiRPPH_BURMS
AccessioniPrimary (citable) accession number: A1V0N7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: November 22, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families