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Protein

2-aminoethylphosphonate--pyruvate transaminase

Gene

phnW

Organism
Burkholderia mallei (strain SAVP1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in phosphonate degradation.UniRule annotation

Catalytic activityi

(2-aminoethyl)phosphonate + pyruvate = 2-phosphonoacetaldehyde + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate, Pyruvate

Enzyme and pathway databases

BioCyciBMAL320388:GHFL-5287-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-aminoethylphosphonate--pyruvate transaminaseUniRule annotation (EC:2.6.1.37UniRule annotation)
Alternative name(s):
2-aminoethylphosphonate aminotransferaseUniRule annotation
AEP transaminaseUniRule annotation
Short name:
AEPTUniRule annotation
Gene namesi
Name:phnWUniRule annotation
Ordered Locus Names:BMASAVP1_1756
OrganismiBurkholderia mallei (strain SAVP1)
Taxonomic identifieri320388 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3693692-aminoethylphosphonate--pyruvate transaminasePRO_1000068245Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei193 – 1931N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA1UZE5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000171816.
KOiK03430.
OMAiVSASGKC.
OrthoDBiEOG6C5RKJ.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01376. PhnW_aminotrans_5.
InterProiIPR000192. Aminotrans_V_dom.
IPR012703. NH2EtPonate_pyrv_transaminase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR024169. SP_NH2Trfase/AEP_transaminase.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF000524. SPT. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03301. PhnW-AepZ. 1 hit.
TIGR02326. transamin_PhnW. 1 hit.

Sequencei

Sequence statusi: Complete.

A1UZE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPERDPILLT PGPLTTSRMT RDAMLRDWGS WDAAFNRLTK SVCADLVRIA
60 70 80 90 100
GGGDAYVCVP LQGSGTFAVE ATLGTLVPRD ARVLVPNNGA YCARIAAILR
110 120 130 140 150
RLGIAHVELP FAEDEPASAH AIDAALARDA RLTHVALVHL ETSAGLLNPL
160 170 180 190 200
DDIAAVCRAR GRALIVDAMS SFGALPIALA ASGIDALISA SGKCLEGVPG
210 220 230 240 250
MGFAIVRRSA LEAAEGRSPS VALDLHDQYA YMQRTSQWRF TPPTHVLAAL
260 270 280 290 300
RAALDQFFDE GGQPARGARY ARNCATLVDG MRALGFEPFL DARAQASVIV
310 320 330 340 350
TFYAPADPAY AFPAFYAAVR DAGYVLYPGK LTTADTFRVG CIGALGADEM
360
RGAVAAIGGA LESLGIAMR
Length:369
Mass (Da):38,859
Last modified:February 6, 2007 - v1
Checksum:i8136927349BAF6F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000525 Genomic DNA. Translation: ABM48425.1.
RefSeqiWP_004194610.1. NC_008784.1.

Genome annotation databases

EnsemblBacteriaiABM48425; ABM48425; BMASAVP1_1756.
KEGGibmv:BMASAVP1_1756.
PATRICi19152749. VBIBurMal134057_1650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000525 Genomic DNA. Translation: ABM48425.1.
RefSeqiWP_004194610.1. NC_008784.1.

3D structure databases

ProteinModelPortaliA1UZE5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM48425; ABM48425; BMASAVP1_1756.
KEGGibmv:BMASAVP1_1756.
PATRICi19152749. VBIBurMal134057_1650.

Phylogenomic databases

HOGENOMiHOG000171816.
KOiK03430.
OMAiVSASGKC.
OrthoDBiEOG6C5RKJ.

Enzyme and pathway databases

BioCyciBMAL320388:GHFL-5287-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01376. PhnW_aminotrans_5.
InterProiIPR000192. Aminotrans_V_dom.
IPR012703. NH2EtPonate_pyrv_transaminase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR024169. SP_NH2Trfase/AEP_transaminase.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF000524. SPT. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03301. PhnW-AepZ. 1 hit.
TIGR02326. transamin_PhnW. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. DeShazer D., Woods D.E., Nierman W.C.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SAVP1.

Entry informationi

Entry nameiPHNW_BURMS
AccessioniPrimary (citable) accession number: A1UZE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 6, 2007
Last modified: November 11, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.