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A1UY21

- TYPH_BURMS

UniProt

A1UY21 - TYPH_BURMS

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Protein

Thymidine phosphorylase

Gene

deoA

Organism
Burkholderia mallei (strain SAVP1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.UniRule annotation

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. phosphorylase activity Source: InterPro
  2. pyrimidine-nucleoside phosphorylase activity Source: InterPro
  3. thymidine phosphorylase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyrimidine nucleobase metabolic process Source: InterPro
  2. pyrimidine nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciBMAL320388:GHFL-4807-MONOMER.
UniPathwayiUPA00578; UER00638.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine phosphorylaseUniRule annotation (EC:2.4.2.4UniRule annotation)
Alternative name(s):
TdRPaseUniRule annotation
Gene namesi
Name:deoAUniRule annotation
Ordered Locus Names:BMASAVP1_1276
OrganismiBurkholderia mallei (strain SAVP1)
Taxonomic identifieri320388 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000006708: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 440440Thymidine phosphorylasePRO_0000335772Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi320388.BMASAVP1_1276.

Structurei

3D structure databases

ProteinModelPortaliA1UY21.
SMRiA1UY21. Positions 3-439.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0213.
HOGENOMiHOG000047313.
KOiK00758.
OrthoDBiEOG61ZTGG.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPiMF_01628. Thymid_phosp.
InterProiIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013465. Thymidine_Pase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02643. T_phosphoryl. 1 hit.
TIGR02644. Y_phosphoryl. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1UY21-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTFLPQEFIR KVRDRAPLDT ADVARFVQGV TAGDVTEGQI AAFAMAVYFN
60 70 80 90 100
ELPLSARIAL TLAQRDSGDV LDWRGARLNG PVVDKHSTGG VGDLTSLVIG
110 120 130 140 150
PMVAACGGYV PMISGRGLGH TGGTLDKLEA IPGYDVAPSV DMLRRVVRDA
160 170 180 190 200
GLAIVGQTAQ LAPADKRIYA VRDVTATVES ISLITASILS KKLAAGVGAL
210 220 230 240 250
AMDVKVGSGA FMPSAEQSAE LARSIVDVGN GAGMRTAATL TDMNQALAPC
260 270 280 290 300
AGNAIEVRCA IDFLTGAARP ARLEAVSFAL AAQMLTMGGL AADAHDARRR
310 320 330 340 350
LRAVLESGAA AERFARMVAA LGGPADLVER PERHLPRAAA AAPVAAARAG
360 370 380 390 400
WIERIDARAL GLAVVGLGGG RAKIGDTLDY SVGLSALAEL GERVEAGQPL
410 420 430 440
ATVHARDADS AAQATDAVRR AYRIGAEPPA QTRVVHAVIE
Length:440
Mass (Da):45,403
Last modified:May 20, 2008 - v2
Checksum:iDDC26DDD6E433A42
GO

Sequence cautioni

The sequence ABM49234.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000525 Genomic DNA. Translation: ABM49234.1. Different initiation.
RefSeqiYP_990874.1. NC_008784.1.

Genome annotation databases

EnsemblBacteriaiABM49234; ABM49234; BMASAVP1_1276.
GeneIDi4678192.
KEGGibmv:BMASAVP1_1276.
PATRICi19151844. VBIBurMal134057_1201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000525 Genomic DNA. Translation: ABM49234.1 . Different initiation.
RefSeqi YP_990874.1. NC_008784.1.

3D structure databases

ProteinModelPortali A1UY21.
SMRi A1UY21. Positions 3-439.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 320388.BMASAVP1_1276.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM49234 ; ABM49234 ; BMASAVP1_1276 .
GeneIDi 4678192.
KEGGi bmv:BMASAVP1_1276.
PATRICi 19151844. VBIBurMal134057_1201.

Phylogenomic databases

eggNOGi COG0213.
HOGENOMi HOG000047313.
KOi K00758.
OrthoDBi EOG61ZTGG.

Enzyme and pathway databases

UniPathwayi UPA00578 ; UER00638 .
BioCyci BMAL320388:GHFL-4807-MONOMER.

Family and domain databases

Gene3Di 3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPi MF_01628. Thymid_phosp.
InterProi IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013465. Thymidine_Pase.
[Graphical view ]
PANTHERi PTHR10515. PTHR10515. 1 hit.
Pfami PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000478. TP_PyNP. 1 hit.
SMARTi SM00941. PYNP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsi TIGR02643. T_phosphoryl. 1 hit.
TIGR02644. Y_phosphoryl. 1 hit.
PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. DeShazer D., Woods D.E., Nierman W.C.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SAVP1.

Entry informationi

Entry nameiTYPH_BURMS
AccessioniPrimary (citable) accession number: A1UY21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 1, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3