A1UWA0 (TRPC_BURMS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	BMASAVP1_0647

Organism

Burkholderia mallei (strain SAVP1) [Complete proteome] [HAMAP]

Taxonomic identifier

320388 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 261	261	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_1000018457

Sequences

	Sequence		Length	Mass (Da)
	A1UWA0 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: B72B5A0EA837CB29	FASTA	261	28,383
	10 20 30 40 50 60 MSDILDKIIA VKREEIAAAL ESAPLEELKV QASARDSRDF VGALRDKHAA GHAAVIAEVK 70 80 90 100 110 120 KASPSKGVLR EHFVPADIAR SYAQHGAACL SVLTDERFFQ GSARYLEQAR AACTLPVLRK 130 140 150 160 170 180 DFIVDAYQLL EARAMGADAI LLIAAALDTP LMIDLEAYAH SLGLAVLVEV HNRGELDEAL 190 200 210 220 230 240 KLKTPFVGIN NRNLRTFETT IDTTLGMLDA IPDDRIVVTE SGILSRADVE RMEAAGVHTF 250 260 LVGEAFMRAE NPGAELARMF F

References

[1]	DeShazer D., Woods D.E., Nierman W.C. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SAVP1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000525 Genomic DNA. Translation: ABM48696.1.
RefSeq	YP_990253.1. NC_008784.1.
3D structure databases
ProteinModelPortal	A1UWA0.
ModBase	Search...
Protein-protein interaction databases
STRING	A1UWA0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4678444.
GenomeReviews	Gene locus BMASAVP1_0647 in contig CP000525_GR.
KEGG	bmv:BMASAVP1_0647.
PATRIC	19150644. VBIBurMal134057_0604.
TIGR	BMASAVP1_0647.
Phylogenomic databases
HOGENOM	HBG540956.
OMA	LEYAVPH.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	BMAL320388:BMASAVP1_0647-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_BURMS

Accession

Primary (citable) accession number: A1UWA0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program