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A1UVC0

- ASPD_BURMS

UniProt

A1UVC0 - ASPD_BURMS

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Protein
Probable L-aspartate dehydrogenase
Gene
nadX, BMASAVP1_0312
Organism
Burkholderia mallei (strain SAVP1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate By similarity.UniRule annotation

Catalytic activityi

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei128 – 1281NAD; via amide nitrogen By similarity
Binding sitei194 – 1941NAD By similarity
Active sitei224 – 2241 By similarity

GO - Molecular functioni

  1. NAD binding Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP
  3. aspartate dehydrogenase activity Source: UniProtKB-EC
  4. oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-HAMAP
  2. NADP catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

BioCyciBMAL320388:GHFL-3844-MONOMER.
UniPathwayiUPA00253; UER00456.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-aspartate dehydrogenase (EC:1.4.1.21)
Gene namesi
Name:nadX
Ordered Locus Names:BMASAVP1_0312
OrganismiBurkholderia mallei (strain SAVP1)
Taxonomic identifieri320388 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
ProteomesiUP000006708: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Probable L-aspartate dehydrogenaseUniRule annotation
PRO_1000067296Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi320388.BMASAVP1_0312.

Structurei

3D structure databases

ProteinModelPortaliA1UVC0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1712.
HOGENOMiHOG000206326.
KOiK06989.
OMAiECAGHSA.
OrthoDBiEOG6ND0JC.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01265. NadX.
InterProiIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR020626. Asp_DH_prok.
IPR011182. L-Asp_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF005227. Asp_dh_NAD_syn. 1 hit.

Sequencei

Sequence statusi: Complete.

A1UVC0-1 [UniParc]FASTAAdd to Basket

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MRNAHAPVDV AMIGFGAIGA AVYRAVEHDA ALRVAHVIVP EHQCDAVRGA    50
LGERVDVVSS VDALACRPQF ALECAGHGAL VDHVVPLLKA GTDCAVASIG 100
ALSDLALLDA LSNAADAGGA TLTLLSGAIG GIDALAAARQ GGLDEVRYIG 150
RKPPLGWLGT PAEAICDLRA MAAEQTIFEG SARDAAQLYP RNANVAATVA 200
LAGVGLDATR VCLIADPAVT RNVHRIVARG AFGEMSIEMS GKPLPDNPKT 250
SALTAFSAIR ALRNRASHCV I 271
Length:271
Mass (Da):27,747
Last modified:February 6, 2007 - v1
Checksum:i5703F6D14871D311
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000525 Genomic DNA. Translation: ABM48564.1.
RefSeqiYP_989923.1. NC_008784.1.

Genome annotation databases

EnsemblBacteriaiABM48564; ABM48564; BMASAVP1_0312.
GeneIDi4677760.
KEGGibmv:BMASAVP1_0312.
PATRICi19150004. VBIBurMal134057_0284.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000525 Genomic DNA. Translation: ABM48564.1 .
RefSeqi YP_989923.1. NC_008784.1.

3D structure databases

ProteinModelPortali A1UVC0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 320388.BMASAVP1_0312.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM48564 ; ABM48564 ; BMASAVP1_0312 .
GeneIDi 4677760.
KEGGi bmv:BMASAVP1_0312.
PATRICi 19150004. VBIBurMal134057_0284.

Phylogenomic databases

eggNOGi COG1712.
HOGENOMi HOG000206326.
KOi K06989.
OMAi ECAGHSA.
OrthoDBi EOG6ND0JC.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00456 .
BioCyci BMAL320388:GHFL-3844-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01265. NadX.
InterProi IPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR020626. Asp_DH_prok.
IPR011182. L-Asp_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF005227. Asp_dh_NAD_syn. 1 hit.
ProtoNeti Search...

Publicationsi

  1. DeShazer D., Woods D.E., Nierman W.C.
    Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SAVP1.

Entry informationi

Entry nameiASPD_BURMS
AccessioniPrimary (citable) accession number: A1UVC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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