A1UUE0 (A1UUE0_BARBK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit B RuleBase RU003363 HAMAP MF_01898
EC=5.99.1.3 RuleBase RU003363 HAMAP MF_01898

Gene names

Name:	gyrB HAMAP MF_01898 EMBL ABM44583.1
Ordered Locus Names:	BARBAKC583_1346

Organism

Bartonella bacilliformis (strain ATCC 35685 / KC583) [Complete proteome] [HAMAP]

Taxonomic identifier

360095 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	809 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. RuleBase RU003363 HAMAP MF_01898
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. RuleBase RU003363 SAAS SAAS002288 HAMAP MF_01898
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01898
Subcellular location	Cytoplasm By similarity HAMAP MF_01898.
Sequence similarities	Belongs to the type II topoisomerase family. HAMAP MF_01898 RuleBase RU000380 Contains 1 Toprim domain. SAAS SAAS002288 HAMAP MF_01898

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_01898
Ligand	ATP-binding SAAS SAAS002288 HAMAP MF_01898 RuleBase RU000380 Nucleotide-binding
Molecular function	Isomerase Topoisomerase SAAS SAAS002288 HAMAP MF_01898 RuleBase RU000380
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1UUE0 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 3F0253B6135E8A9E	FASTA	809	89,292
	10 20 30 40 50 60 MSDETTSPTS GDYGAASIKV LKGLDAVRKR PGMYIGDTDD GSGLHHMVYE VVDNAIDEAL 70 80 90 100 110 120 AGYATLVNVT LHADGSCSVC DNGRGIPTDI HPTEHVSAAE VIMTQLHAGG KFDQNSYKVS 130 140 150 160 170 180 GGLHGVGVSV VNALSVWLRL RIKRDGKIHE MSFTHGVADA PLKVVGQCGT ESGTEISFLP 190 200 210 220 230 240 SPETFTMVKF DFETLERRLR ELAFLNSGVH ILLVNQHHAD VRSVELYYEG GLIEFIKYID 250 260 270 280 290 300 QSKKPLIDAP IYITSEKDGI SVDVALWWND SYHEKVLCFT NNIPQRDGGT HLAGFRSALT 310 320 330 340 350 360 RQINGYAESS GIAKKEKVNL TGDDCREGLT AILSVKVPDP KFSSQTKDKL VSSEVRPIVE 370 380 390 400 410 420 NLVNEGLSAW LEEHPNEAKI LISKVVEAAA AREAARKARE LTRRKGALDI TSLPGKLADC 430 440 450 460 470 480 QERDPTKSEI FIVEGDSAGG SAKSGRSRQN QAILPLRGKI LNVERARFDR MLSSEMIGTL 490 500 510 520 530 540 ITALGTSIGK DEFSPDKLRY HKIIIMTDAD VDGAHIRTLL LTFFFRQMPE LIERGHLYIA 550 560 570 580 590 600 QPPLYKVSRG KSSQYIKNEA AFEDFLIDSG LEETTLELSS GEVCAGIDLR QFVQDARLLR 610 620 630 640 650 660 QLLNGLHTRY DRNIVEQAAI AGAFNFEAFA TPETAQKIAD TIAKRLDLIA DDMERGWSGQ 670 680 690 700 710 720 YTSDGSLCFE RVLRGVKDVI TLDAGFINSA DARQIGHIAK NLKDIYRDPP LLRRKDKSER 730 740 750 760 770 780 IFGPTSLLES IFINGKKGIT LQRYKGLGEM NADQLWETTL DPDARSLLQV KINDATDADS 790 800 LFSQLMGDEV EPRRIFIQKN ALNVANLDI

References

[1]

Hendrix L., Mohamoud Y., Radune D., Shvartsbeyn A., Daugherty S., Dodson R., Durkin A.S., Harkins D., Huot H., Kothari S.P., Madupu R., Li J., Nelson W.C., Shrivastava S., Giglio M.G., Haft D., Selengut J., Fraser-Ligget C., Seshadri R. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000524 Genomic DNA. Translation: ABM44583.1.
RefSeq	YP_989593.1. NC_008783.1.
3D structure databases
ProteinModelPortal	A1UUE0.
SMR	A1UUE0. Positions 18-387.
ModBase	Search...
Protein-protein interaction databases
STRING	A1UUE0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4684252.
GenomeReviews	Gene locus BARBAKC583_1346 in contig CP000524_GR.
KEGG	bbk:BARBAKC583_1346.
NMPDR	fig|360095.3.peg.1147.
PATRIC	20539013. VBIBarBac6912_1319.
TIGR	BARBAKC583_1346.
Phylogenomic databases
eggNOG	COG0187.
HOGENOM	HBG304889.
OMA	DCSSRDP.
ProtClustDB	PRK14939.
Family and domain databases
HAMAP	MF_01898. GyrB. [Tree]
InterPro	IPR003594. ATPase-like_ATP-bd. IPR011557. GyrB. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR001241. Topo_IIA. IPR013759. Topo_IIA_B/N_ab. IPR002288. Topo_IIA_B_C. IPR013506. Topo_IIA_bsu_dom2. IPR013760. Topo_IIA_cen. IPR018522. TopoIIA_CS. IPR006171. Toprim_domain. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit. G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit. G3DSA:3.40.50.670. Topo_IIA_B/N_ab. 2 hits.
KO	K02470.
Pfam	PF00204. DNA_gyraseB. 1 hit. PF00986. DNA_gyraseB_C. 1 hit. PF02518. HATPase_c. 1 hit. PF01751. Toprim. 1 hit. [Graphical view]
PRINTS	PR00418. TPI2FAMILY.
SMART	SM00387. HATPase_c. 1 hit. SM00433. TOP2c. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit. SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01059. GyrB. 1 hit.
PROSITE	PS00177. TOPOISOMERASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A1UUE0_BARBK

Accession

Primary (citable) accession number: A1UUE0

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)