Reviewed, UniProtKB/Swiss-Prot A1UUC1 (ARGB_BARBK)

Names and origin

Protein names

Recommended name:
    Acetylglutamate kinase
    EC=2.7.2.8
Alternative name(s):
    NAG kinase
      Short name=AGK
    N-acetyl-L-glutamate 5-phosphotransferase

Gene names

Name:	argB
Ordered Locus Names:	BARBAKC583_1326

Organism

Bartonella bacilliformis (strain ATCC 35685 / KC583) [Complete proteome] [HAMAP]

Taxonomic identifier

360095 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP acetylglutamate kinase activity Inferred from electronic annotation. Source: HAMAP glutamate 5-kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 301	301	Acetylglutamate kinase HAMAP MF_00082		PRO_1000010485
Regions
	Region	72 – 73	2	Substrate binding By similarity
Sites
	Binding site	94	1	Substrate By similarity
	Binding site	199	1	Substrate By similarity
	Site	37	1	Transition state stabilizer By similarity
	Site	259	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1UUC1-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: E64892E8DD3B3CAB	FASTA	301	32,044
	10 20 30 40 50 60 MDNVANNDVD VLEKQAAFLS SALPYMQKYE NETVVIKYGG HAMGNLALGQ AFARDIALLK 70 80 90 100 110 120 QSGVNPIVVH GGGPRIAETL KKMGIESRFE SGLRVTDEKI VEVVEMVLAG SINKEIVALI 130 140 150 160 170 180 NAEGEWAIGL CGKDGNMVFA EKVHKTVIDP NSNSERVLDL GFVGEPVEID RTLLDFLACS 190 200 210 220 230 240 EMIPVIAPIA PGRDGKTYNI NADIFAGAIA GALEAKRLLF LTDVPGVLDK EGKVLKELTV 250 260 270 280 290 300 TEAKNLIKDG TISGGMIPKV ETCINAIQGG VEGVVILNGK TSHPVLLELF TEHGAGTLII S

References

[1]

Hendrix L., Mohamoud Y., Radune D., Shvartsbeyn A., Daugherty S., Dodson R., Durkin A.S., Harkins D., Huot H., Kothari S.P., Madupu R., Li J., Nelson W.C., Shrivastava S., Giglio M.G., Haft D., Selengut J., Fraser-Ligget C., Seshadri R. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000524 Genomic DNA. Translation: ABM45266.1.
RefSeq	YP_989574.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1UUC1.
Genome annotation databases
GeneID	4684528.
GenomeReviews	Gene locus BARBAKC583_1326 in contig CP000524_GR.
KEGG	bbk:BARBAKC583_1326.
NMPDR	fig|360095.3.peg.108.
TIGR	BARBAKC583_1326.
Phylogenomic databases
OMA	FVIKYGG.
Family and domain databases
HAMAP	MF_00082. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. IPR011148. GlcNAc_kinase. IPR001057. Glu_5kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
PRINTS	PR00474. GLU5KINASE.
TIGRFAMs	TIGR00761. argB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_BARBK

Accession

Primary (citable) accession number: A1UUC1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	November 3, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)