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A1UUB4

- DEF_BARBK

UniProt

A1UUB4 - DEF_BARBK

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Protein

Peptide deformylase

Gene

def

Organism
Bartonella bacilliformis (strain ATCC 35685 / KC583)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe(2+) ion.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi100 – 1001IronUniRule annotation
Metal bindingi142 – 1421IronUniRule annotation
Active sitei143 – 1431UniRule annotation
Metal bindingi146 – 1461IronUniRule annotation

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciBBAC360095:GHRY-1320-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDFUniRule annotation
Alternative name(s):
Polypeptide deformylaseUniRule annotation
Gene namesi
Name:defUniRule annotation
Ordered Locus Names:BARBAKC583_1319
OrganismiBartonella bacilliformis (strain ATCC 35685 / KC583)
Taxonomic identifieri360095 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000000643: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 182182Peptide deformylasePRO_0000301006Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360095.BARBAKC583_1319.

Structurei

3D structure databases

ProteinModelPortaliA1UUB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243509.
KOiK01462.
OMAiELLAICI.
OrthoDBiEOG664CMF.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

A1UUB4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPIKPLVILP DPILREISKP VEHIDSTIQQ LADDMLETMY NAGGIGLAAI
60 70 80 90 100
QVGIPLRMLV VDVSIFTSIF EPDAPQDPII VINPEILWLS DERNICMEGC
110 120 130 140 150
LSIPGYSAEV ERPKRLCIRY RNREGEQKEI EADNILATCL QHEIDHLNGC
160 170 180
LFIDHLSKVK RNMVIRKFEK RAKENNLEKE IL
Length:182
Mass (Da):20,739
Last modified:February 6, 2007 - v1
Checksum:i3B275816BCEBF800
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000524 Genomic DNA. Translation: ABM44951.1.
RefSeqiYP_989567.1. NC_008783.1.

Genome annotation databases

EnsemblBacteriaiABM44951; ABM44951; BARBAKC583_1319.
GeneIDi4684713.
KEGGibbk:BARBAKC583_1319.
PATRICi20538957. VBIBarBac6912_1291.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000524 Genomic DNA. Translation: ABM44951.1 .
RefSeqi YP_989567.1. NC_008783.1.

3D structure databases

ProteinModelPortali A1UUB4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360095.BARBAKC583_1319.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM44951 ; ABM44951 ; BARBAKC583_1319 .
GeneIDi 4684713.
KEGGi bbk:BARBAKC583_1319.
PATRICi 20538957. VBIBarBac6912_1291.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243509.
KOi K01462.
OMAi ELLAICI.
OrthoDBi EOG664CMF.

Enzyme and pathway databases

BioCyci BBAC360095:GHRY-1320-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35685 / KC583.

Entry informationi

Entry nameiDEF_BARBK
AccessioniPrimary (citable) accession number: A1UUB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 6, 2007
Last modified: November 26, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3