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A1UUA2

- PNCB_BARBK

UniProt

A1UUA2 - PNCB_BARBK

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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Bartonella bacilliformis (strain ATCC 35685 / KC583)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciBBAC360095:GHRY-1308-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:BARBAKC583_1307
OrganismiBartonella bacilliformis (strain ATCC 35685 / KC583)
Taxonomic identifieri360095 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000000643: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424Nicotinate phosphoribosyltransferasePRO_1000146828Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360095.BARBAKC583_1307.

Structurei

3D structure databases

ProteinModelPortaliA1UUA2.
SMRiA1UUA2. Positions 1-422.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284929.
KOiK00763.
OMAiQAVFHRY.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

A1UUA2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNHTDIAKRV YNHTWKLDPI VRSLLDTDFY KLLMLQMIWG LYPDVHVTFS
60 70 80 90 100
LINRNKAIHL ADDIDEGELR AQLDHTLSLR FTKKEIIWLA GNTFYGQKQI
110 120 130 140 150
FKPDFLHWLE NFQLPDYELS RKDGQYILHF HGSWAYSSMW EIPALTIISE
160 170 180 190 200
LRSRAAMKNL DRFALDVLYA RAKAKMWSKI ERLKKLPDIK ISDFGTRRRH
210 220 230 240 250
SFLWQRWCVE ALKEGIGASF TGTSNVLLAM DTDLEALGTN AHELPMVIAA
260 270 280 290 300
LTNNDDDLRK APYQVLQDWK RYYEGNLLIV LPDTFGTEAF LRNAPKWVAD
310 320 330 340 350
WTGFRPDSAP PIEGGERIIQ WWQEQGKKPQ EKLLIFSDAL DVDTIEKTYH
360 370 380 390 400
HFHGKVRMIF GWGTNLTNDF ANCAPQEIAD LDVTSLVCKV TSANGRPAVK
410 420
LSDNPEKTIG NPQEIQRYLN FFSH
Length:424
Mass (Da):49,130
Last modified:February 6, 2007 - v1
Checksum:iC14ED7463F8457A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000524 Genomic DNA. Translation: ABM45235.1.
RefSeqiYP_989555.1. NC_008783.1.

Genome annotation databases

EnsemblBacteriaiABM45235; ABM45235; BARBAKC583_1307.
GeneIDi4684516.
KEGGibbk:BARBAKC583_1307.
PATRICi20538933. VBIBarBac6912_1279.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000524 Genomic DNA. Translation: ABM45235.1 .
RefSeqi YP_989555.1. NC_008783.1.

3D structure databases

ProteinModelPortali A1UUA2.
SMRi A1UUA2. Positions 1-422.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360095.BARBAKC583_1307.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM45235 ; ABM45235 ; BARBAKC583_1307 .
GeneIDi 4684516.
KEGGi bbk:BARBAKC583_1307.
PATRICi 20538933. VBIBarBac6912_1279.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284929.
KOi K00763.
OMAi QAVFHRY.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci BBAC360095:GHRY-1308-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35685 / KC583.

Entry informationi

Entry nameiPNCB_BARBK
AccessioniPrimary (citable) accession number: A1UUA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3