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A1UUA2 (PNCB_BARBK) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nicotinate phosphoribosyltransferase

Short name=NAPRTase
EC=6.3.4.21
Gene names
Name:pncB
Ordered Locus Names:BARBAKC583_1307
OrganismBartonella bacilliformis (strain ATCC 35685 / KC583) [Complete proteome] [HAMAP]
Taxonomic identifier360095 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella

Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity. HAMAP-Rule MF_00570

Catalytic activity

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate. HAMAP-Rule MF_00570

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP-Rule MF_00570

Sequence similarities

Belongs to the NAPRTase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 424424Nicotinate phosphoribosyltransferase HAMAP-Rule MF_00570
PRO_1000146828

Sequences

Sequence LengthMass (Da)Tools
A1UUA2 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: C14ED7463F8457A1

FASTA42449,130
        10         20         30         40         50         60 
MNHTDIAKRV YNHTWKLDPI VRSLLDTDFY KLLMLQMIWG LYPDVHVTFS LINRNKAIHL 

        70         80         90        100        110        120 
ADDIDEGELR AQLDHTLSLR FTKKEIIWLA GNTFYGQKQI FKPDFLHWLE NFQLPDYELS 

       130        140        150        160        170        180 
RKDGQYILHF HGSWAYSSMW EIPALTIISE LRSRAAMKNL DRFALDVLYA RAKAKMWSKI 

       190        200        210        220        230        240 
ERLKKLPDIK ISDFGTRRRH SFLWQRWCVE ALKEGIGASF TGTSNVLLAM DTDLEALGTN 

       250        260        270        280        290        300 
AHELPMVIAA LTNNDDDLRK APYQVLQDWK RYYEGNLLIV LPDTFGTEAF LRNAPKWVAD 

       310        320        330        340        350        360 
WTGFRPDSAP PIEGGERIIQ WWQEQGKKPQ EKLLIFSDAL DVDTIEKTYH HFHGKVRMIF 

       370        380        390        400        410        420 
GWGTNLTNDF ANCAPQEIAD LDVTSLVCKV TSANGRPAVK LSDNPEKTIG NPQEIQRYLN 


FFSH 

« Hide

References

[1]Hendrix L., Mohamoud Y., Radune D., Shvartsbeyn A., Daugherty S., Dodson R., Durkin A.S., Harkins D., Huot H., Kothari S.P., Madupu R., Li J., Nelson W.C., Shrivastava S., Giglio M.G., Haft D., Selengut J., Fraser-Ligget C., Seshadri R.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35685 / KC583.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000524 Genomic DNA. Translation: ABM45235.1.
RefSeqYP_989555.1. NC_008783.1.

3D structure databases

ProteinModelPortalA1UUA2.
SMRA1UUA2. Positions 1-422.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING360095.BARBAKC583_1307.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM45235; ABM45235; BARBAKC583_1307.
GeneID4684516.
KEGGbbk:BARBAKC583_1307.
PATRIC20538933. VBIBarBac6912_1279.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1488.
HOGENOMHOG000284929.
KOK00763.
OMAKLTMQCA.
OrthoDBEOG6X10XB.
ProtClustDBPRK05321.

Enzyme and pathway databases

BioCycBBAC360095:GHRY-1308-MONOMER.
UniPathwayUPA00253; UER00457.

Family and domain databases

HAMAPMF_00570. NAPRTase.
InterProIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERPTHR11098:SF1. PTHR11098:SF1. 1 hit.
PfamPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFPIRSF000484. NAPRT. 1 hit.
SUPFAMSSF51690. SSF51690. 1 hit.
TIGRFAMsTIGR01514. NAPRTase. 1 hit.
ProtoNetSearch...

Entry information

Entry namePNCB_BARBK
AccessionPrimary (citable) accession number: A1UUA2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 6, 2007
Last modified: March 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways