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A1UU54

- PNP_BARBK

UniProt

A1UU54 - PNP_BARBK

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, BARBAKC583_1258
Organism
Bartonella bacilliformis (strain ATCC 35685 / KC583)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi488 – 4881Magnesium By similarity
Metal bindingi494 – 4941Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciBBAC360095:GHRY-1259-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:BARBAKC583_1258
OrganismiBartonella bacilliformis (strain ATCC 35685 / KC583)
Taxonomic identifieri360095 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000000643: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 733733Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329526Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360095.BARBAKC583_1258.

Structurei

3D structure databases

ProteinModelPortaliA1UU54.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini555 – 61460KH
Add
BLAST
Domaini624 – 69269S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1UU54-1 [UniParc]FASTAAdd to Basket

« Hide

MFKTHKVEIE WAGRPLTIET GRVARQADGA VVATYGETVV LATVVSAKAP    50
KPDQDFFPLT VNYQEKTYAV GKIPGGYFKR ESRPSENETL ISRLIDRPIR 100
PLFVDDYKND TQVIVSVIQH DLENNPDILS MIAASAALTL SGIPFMGPIA 150
GARVGYCNGH YVLNPTLDEM PESKLDLVVA GTENAVLMVE SEAHELSEEV 200
MLGAITFGQK GFQPVIDAII QLAEVAAKEP REFIPEDFSD LEKTMLKMIE 250
KDLRKAYTIT DKQQRYDAID AIKTEILSKF APEMEVNCEL TADKIATVFK 300
RLQAKIVRWN ILDTGKRIDG RDLSTVRPIQ SEVGILPRTH GSALFTRGET 350
QALVVATLGT SEDEQYVDLL TGVCKETFLL HYNFPPFSVG ETGRLSSPGR 400
REIGHGKLAW RAIHPMLPTK EAFPYTIRVV SEITESNGSS SMATVCGTSL 450
ALMDAGVPLA RPVAGIAMGL IKEGERFVIL SDILGDEDHL GDMDFKVAGT 500
KNGITSLQMD IKIDGITEDI MKIALEQAKD GRNHILNEMA KALTDARTEL 550
SEFSPRIEMM TIPVEKIREV IGSGGKVIRE IVEQTGAKIN IEDDGTIKIA 600
SPDTKSIETA KSWIHSIVDE PEVGTIYQGT VVKTTEFGAF INFFGSHDGL 650
VHISQLASKR VAKTTDVVKE GDKVWVQLMG FDERGKIRLS MKVVDQQTGK 700
EIPQDDLIKT EKEQNPDEKN KSEKKRHNRK KED 733
Length:733
Mass (Da):81,041
Last modified:February 6, 2007 - v1
Checksum:i2C89AEC166F9B458
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000524 Genomic DNA. Translation: ABM45418.1.
RefSeqiYP_989507.1. NC_008783.1.

Genome annotation databases

EnsemblBacteriaiABM45418; ABM45418; BARBAKC583_1258.
GeneIDi4684005.
KEGGibbk:BARBAKC583_1258.
PATRICi20538841. VBIBarBac6912_1234.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000524 Genomic DNA. Translation: ABM45418.1 .
RefSeqi YP_989507.1. NC_008783.1.

3D structure databases

ProteinModelPortali A1UU54.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360095.BARBAKC583_1258.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM45418 ; ABM45418 ; BARBAKC583_1258 .
GeneIDi 4684005.
KEGGi bbk:BARBAKC583_1258.
PATRICi 20538841. VBIBarBac6912_1234.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci BBAC360095:GHRY-1259-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35685 / KC583.

Entry informationi

Entry nameiPNP_BARBK
AccessioniPrimary (citable) accession number: A1UU54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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