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A1UU54

- PNP_BARBK

UniProt

A1UU54 - PNP_BARBK

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Bartonella bacilliformis (strain ATCC 35685 / KC583)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi488 – 4881MagnesiumUniRule annotation
Metal bindingi494 – 4941MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciBBAC360095:GHRY-1259-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:BARBAKC583_1258
OrganismiBartonella bacilliformis (strain ATCC 35685 / KC583)
Taxonomic identifieri360095 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000000643: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 733733Polyribonucleotide nucleotidyltransferasePRO_0000329526Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360095.BARBAKC583_1258.

Structurei

3D structure databases

ProteinModelPortaliA1UU54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini555 – 61460KHUniRule annotationAdd
BLAST
Domaini624 – 69269S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1UU54-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFKTHKVEIE WAGRPLTIET GRVARQADGA VVATYGETVV LATVVSAKAP
60 70 80 90 100
KPDQDFFPLT VNYQEKTYAV GKIPGGYFKR ESRPSENETL ISRLIDRPIR
110 120 130 140 150
PLFVDDYKND TQVIVSVIQH DLENNPDILS MIAASAALTL SGIPFMGPIA
160 170 180 190 200
GARVGYCNGH YVLNPTLDEM PESKLDLVVA GTENAVLMVE SEAHELSEEV
210 220 230 240 250
MLGAITFGQK GFQPVIDAII QLAEVAAKEP REFIPEDFSD LEKTMLKMIE
260 270 280 290 300
KDLRKAYTIT DKQQRYDAID AIKTEILSKF APEMEVNCEL TADKIATVFK
310 320 330 340 350
RLQAKIVRWN ILDTGKRIDG RDLSTVRPIQ SEVGILPRTH GSALFTRGET
360 370 380 390 400
QALVVATLGT SEDEQYVDLL TGVCKETFLL HYNFPPFSVG ETGRLSSPGR
410 420 430 440 450
REIGHGKLAW RAIHPMLPTK EAFPYTIRVV SEITESNGSS SMATVCGTSL
460 470 480 490 500
ALMDAGVPLA RPVAGIAMGL IKEGERFVIL SDILGDEDHL GDMDFKVAGT
510 520 530 540 550
KNGITSLQMD IKIDGITEDI MKIALEQAKD GRNHILNEMA KALTDARTEL
560 570 580 590 600
SEFSPRIEMM TIPVEKIREV IGSGGKVIRE IVEQTGAKIN IEDDGTIKIA
610 620 630 640 650
SPDTKSIETA KSWIHSIVDE PEVGTIYQGT VVKTTEFGAF INFFGSHDGL
660 670 680 690 700
VHISQLASKR VAKTTDVVKE GDKVWVQLMG FDERGKIRLS MKVVDQQTGK
710 720 730
EIPQDDLIKT EKEQNPDEKN KSEKKRHNRK KED
Length:733
Mass (Da):81,041
Last modified:February 6, 2007 - v1
Checksum:i2C89AEC166F9B458
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000524 Genomic DNA. Translation: ABM45418.1.
RefSeqiWP_005767993.1. NC_008783.1.
YP_989507.1. NC_008783.1.

Genome annotation databases

EnsemblBacteriaiABM45418; ABM45418; BARBAKC583_1258.
GeneIDi4684005.
KEGGibbk:BARBAKC583_1258.
PATRICi20538841. VBIBarBac6912_1234.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000524 Genomic DNA. Translation: ABM45418.1 .
RefSeqi WP_005767993.1. NC_008783.1.
YP_989507.1. NC_008783.1.

3D structure databases

ProteinModelPortali A1UU54.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360095.BARBAKC583_1258.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM45418 ; ABM45418 ; BARBAKC583_1258 .
GeneIDi 4684005.
KEGGi bbk:BARBAKC583_1258.
PATRICi 20538841. VBIBarBac6912_1234.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci BBAC360095:GHRY-1259-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35685 / KC583.

Entry informationi

Entry nameiPNP_BARBK
AccessioniPrimary (citable) accession number: A1UU54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: February 6, 2007
Last modified: November 26, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3