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A1UU46

- TRMB_BARBK

UniProt

A1UU46 - TRMB_BARBK

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, BARBAKC583_1250
Organism
Bartonella bacilliformis (strain ATCC 35685 / KC583)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621S-adenosyl-L-methionine By similarity
Binding sitei87 – 871S-adenosyl-L-methionine By similarity
Binding sitei116 – 1161S-adenosyl-L-methionine By similarity
Active sitei138 – 1381 By similarity
Binding sitei138 – 1381S-adenosyl-L-methionine By similarity
Binding sitei142 – 1421Substrate By similarity
Binding sitei174 – 1741Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciBBAC360095:GHRY-1251-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:BARBAKC583_1250
OrganismiBartonella bacilliformis (strain ATCC 35685 / KC583)
Taxonomic identifieri360095 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000000643: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_0000288124Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360095.BARBAKC583_1250.

Structurei

3D structure databases

ProteinModelPortaliA1UU46.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni212 – 2154Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073969.
KOiK03439.
OMAiYLTFIKK.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1UU46-1 [UniParc]FASTAAdd to Basket

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MIAHKPCIDK AFFGRRQGKQ LRSNQLTSIK TLLPILNIDL NKPAPSDLTS    50
LFTDLVKEIR LEIGFGGGEH LCHEMARFPQ TGFIGVEPFI NGMAKMLMYL 100
EKYTQHQNHL RLYDDDATYL LDWLPEESLN GIDLFYPDPW PKKKHWKRRF 150
INVKNLDRFA RVLKKGGKFR FASDIDTYVN WTLYYFTNHI SFEWQSDTPK 200
DWKIPYPLWP STRYEAKALR ENRVPTYLTF IKK 233
Length:233
Mass (Da):27,609
Last modified:February 6, 2007 - v1
Checksum:i7AB417BBEF5ABEE4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000524 Genomic DNA. Translation: ABM45255.1.
RefSeqiYP_989499.1. NC_008783.1.

Genome annotation databases

EnsemblBacteriaiABM45255; ABM45255; BARBAKC583_1250.
GeneIDi4683944.
KEGGibbk:BARBAKC583_1250.
PATRICi20538825. VBIBarBac6912_1226.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000524 Genomic DNA. Translation: ABM45255.1 .
RefSeqi YP_989499.1. NC_008783.1.

3D structure databases

ProteinModelPortali A1UU46.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360095.BARBAKC583_1250.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM45255 ; ABM45255 ; BARBAKC583_1250 .
GeneIDi 4683944.
KEGGi bbk:BARBAKC583_1250.
PATRICi 20538825. VBIBarBac6912_1226.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073969.
KOi K03439.
OMAi YLTFIKK.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci BBAC360095:GHRY-1251-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35685 / KC583.

Entry informationi

Entry nameiTRMB_BARBK
AccessioniPrimary (citable) accession number: A1UU46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: February 6, 2007
Last modified: June 11, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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