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A1UU46

- TRMB_BARBK

UniProt

A1UU46 - TRMB_BARBK

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Bartonella bacilliformis (strain ATCC 35685 / KC583)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei62 – 621S-adenosyl-L-methionineUniRule annotation
    Binding sitei87 – 871S-adenosyl-L-methionineUniRule annotation
    Binding sitei116 – 1161S-adenosyl-L-methionineUniRule annotation
    Active sitei138 – 1381By similarity
    Binding sitei138 – 1381S-adenosyl-L-methionineUniRule annotation
    Binding sitei142 – 1421SubstrateUniRule annotation
    Binding sitei174 – 1741SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciBBAC360095:GHRY-1251-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:BARBAKC583_1250
    OrganismiBartonella bacilliformis (strain ATCC 35685 / KC583)
    Taxonomic identifieri360095 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
    ProteomesiUP000000643: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 233233tRNA (guanine-N(7)-)-methyltransferasePRO_0000288124Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi360095.BARBAKC583_1250.

    Structurei

    3D structure databases

    ProteinModelPortaliA1UU46.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni212 – 2154Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073969.
    KOiK03439.
    OMAiYLTFIKK.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1UU46-1 [UniParc]FASTAAdd to Basket

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    MIAHKPCIDK AFFGRRQGKQ LRSNQLTSIK TLLPILNIDL NKPAPSDLTS    50
    LFTDLVKEIR LEIGFGGGEH LCHEMARFPQ TGFIGVEPFI NGMAKMLMYL 100
    EKYTQHQNHL RLYDDDATYL LDWLPEESLN GIDLFYPDPW PKKKHWKRRF 150
    INVKNLDRFA RVLKKGGKFR FASDIDTYVN WTLYYFTNHI SFEWQSDTPK 200
    DWKIPYPLWP STRYEAKALR ENRVPTYLTF IKK 233
    Length:233
    Mass (Da):27,609
    Last modified:February 6, 2007 - v1
    Checksum:i7AB417BBEF5ABEE4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000524 Genomic DNA. Translation: ABM45255.1.
    RefSeqiYP_989499.1. NC_008783.1.

    Genome annotation databases

    EnsemblBacteriaiABM45255; ABM45255; BARBAKC583_1250.
    GeneIDi4683944.
    KEGGibbk:BARBAKC583_1250.
    PATRICi20538825. VBIBarBac6912_1226.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000524 Genomic DNA. Translation: ABM45255.1 .
    RefSeqi YP_989499.1. NC_008783.1.

    3D structure databases

    ProteinModelPortali A1UU46.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 360095.BARBAKC583_1250.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM45255 ; ABM45255 ; BARBAKC583_1250 .
    GeneIDi 4683944.
    KEGGi bbk:BARBAKC583_1250.
    PATRICi 20538825. VBIBarBac6912_1226.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073969.
    KOi K03439.
    OMAi YLTFIKK.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci BBAC360095:GHRY-1251-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35685 / KC583.

    Entry informationi

    Entry nameiTRMB_BARBK
    AccessioniPrimary (citable) accession number: A1UU46
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3