Reviewed, UniProtKB/Swiss-Prot A1UTM3 (DAPB_BARBK)

Names and origin

Protein names

Recommended name:
    Dihydrodipicolinate reductase
      Short name=DHPR
    EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	BARBAKC583_1051

Organism

Bartonella bacilliformis (strain ATCC 35685 / KC583) [Complete proteome] [HAMAP]

Taxonomic identifier

360095 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = 2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity HAMAP MF_00102.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_1000008536

Sequences

	Sequence		Length	Mass (Da)
	A1UTM3-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 776A36B359ED207B	FASTA	268	28,542
	10 20 30 40 50 60 MRLVVVGANG RMGRELITAC QNREDIELSG VLVREKSPFV GQDVSILIGS APLGIRITDD 70 80 90 100 110 120 PENAFSNADG IVDFSQPQAS VIHADYAAQK GLVHIIGTTG FSKEEDAQIA ISATRTTIVK 130 140 150 160 170 180 SENMSLGVNL LANFVKKAAK ALGAHDFDIE ICEMHHSKKV DAPSGTALLL GNAAAEGRHV 190 200 210 220 230 240 ALKEVSASGR NGYTGERKKG TIGFACLRGG TVIGDHSVIF AGLNERITFS HSAQERSIFA 250 260 HGALKAALWA KNYKNGLYSM LDVLELNN

References

[1]

Hendrix L., Mohamoud Y., Radune D., Shvartsbeyn A., Daugherty S., Dodson R., Durkin A.S., Harkins D., Huot H., Kothari S.P., Madupu R., Li J., Nelson W.C., Shrivastava S., Giglio M.G., Haft D., Selengut J., Fraser-Ligget C., Seshadri R. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000524 Genomic DNA. Translation: ABM44744.1.
RefSeq	YP_989326.1.
3D structure databases
SMR	A1UTM3. Positions 1-268.
ModBase	Search...
Protein-protein interaction databases
STRING	A1UTM3.
Genome annotation databases
GeneID	4684201.
GenomeReviews	Gene locus BARBAKC583_1051 in contig CP000524_GR.
KEGG	bbk:BARBAKC583_1051.
NMPDR	fig|360095.3.peg.644.
TIGR	BARBAKC583_1051.
Phylogenomic databases
eggNOG	COG0289.
HOGENOM	HBG594002.
OMA	TIGFSTI.
Family and domain databases
HAMAP	MF_00102. DapB. [Tree]
InterPro	IPR000846. DapB. IPR011770. Dihydrodipicolinate_Rdtase. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00036. dapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_BARBK

Accession

Primary (citable) accession number: A1UTM3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	February 9, 2010
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)