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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Bartonella bacilliformis (strain ATCC 35685 / KC583)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBBAC360095:G1G7W-892-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:BARBAKC583_0950
OrganismiBartonella bacilliformis (strain ATCC 35685 / KC583)
Taxonomic identifieri360095 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi
  • UP000000643 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalUniRule annotationAdd BLAST21
Transmembranei70 – 90HelicalUniRule annotationAdd BLAST21
Transmembranei93 – 113HelicalUniRule annotationAdd BLAST21
Transmembranei138 – 158HelicalUniRule annotationAdd BLAST21
Transmembranei164 – 184HelicalUniRule annotationAdd BLAST21
Transmembranei195 – 215HelicalUniRule annotationAdd BLAST21
Transmembranei232 – 252HelicalUniRule annotationAdd BLAST21
Transmembranei258 – 278HelicalUniRule annotationAdd BLAST21
Transmembranei284 – 304HelicalUniRule annotationAdd BLAST21
Transmembranei333 – 353HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000029381 – 356Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST356

Interactioni

Protein-protein interaction databases

STRINGi360095.BARBAKC583_0950

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY Bacteria
COG0472 LUCA
HOGENOMiHOG000275122
KOiK01000
OMAiLMSPLHH
OrthoDBiPOG091H00VH

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
PF10555 MraY_sig1, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01347 MRAY_1, 1 hit
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

A1UTC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLFFSSLYD WLPGVNVFRY ITFRTVAAML TSGLIVFLFG PSIISSLKVR
60 70 80 90 100
QGKGQPIRAD GPQTHFKKAG TPTMGGLMIL SGVVISALLW GNLFNIYLWV
110 120 130 140 150
SLFVMLFFGA IGFYDDYLKV TKQTDKGFSG KARLSLEFLV ASIASFIILQ
160 170 180 190 200
VGSPGLALPF VKEYFINLGW FFIPFSACVV VGLGNAVNLT DGLDGLAIVP
210 220 230 240 250
VMVASLSFAL IAYLSGNINF ADYLQIHYVS GVGELAVLLG AVFGAGLGFL
260 270 280 290 300
WFNAPPAAIF MGDTGSLALG GLLGIVSVAT KHEIVLIFIG GLFVLETLSV
310 320 330 340 350
IIQVGWFKLT KKRVFLMAPI HHHFEKKGWT ESQIVVRFWI IAIVLALIGL

STLKLR
Length:356
Mass (Da):38,721
Last modified:February 6, 2007 - v1
Checksum:i3B3A0FE407101B99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000524 Genomic DNA Translation: ABM44543.1
RefSeqiWP_005767435.1, NC_008783.1

Genome annotation databases

EnsemblBacteriaiABM44543; ABM44543; BARBAKC583_0950
GeneIDi4684086
KEGGibbk:BARBAKC583_0950
PATRICifig|360095.6.peg.921

Similar proteinsi

Entry informationi

Entry nameiMRAY_BARBK
AccessioniPrimary (citable) accession number: A1UTC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: February 28, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health