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A1UTC8 (MRAY_BARBK) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:BARBAKC583_0950
OrganismBartonella bacilliformis (strain ATCC 35685 / KC583) [Complete proteome] [HAMAP]
Taxonomic identifier360095 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 356356Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_1000002938

Regions

Transmembrane25 – 4521Helical; Potential
Transmembrane70 – 9021Helical; Potential
Transmembrane93 – 11321Helical; Potential
Transmembrane138 – 15821Helical; Potential
Transmembrane164 – 18421Helical; Potential
Transmembrane195 – 21521Helical; Potential
Transmembrane232 – 25221Helical; Potential
Transmembrane258 – 27821Helical; Potential
Transmembrane284 – 30421Helical; Potential
Transmembrane333 – 35321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A1UTC8 [UniParc].

Last modified February 6, 2007. Version 1.
Checksum: 3B3A0FE407101B99

FASTA35638,721
        10         20         30         40         50         60 
MMLFFSSLYD WLPGVNVFRY ITFRTVAAML TSGLIVFLFG PSIISSLKVR QGKGQPIRAD 

        70         80         90        100        110        120 
GPQTHFKKAG TPTMGGLMIL SGVVISALLW GNLFNIYLWV SLFVMLFFGA IGFYDDYLKV 

       130        140        150        160        170        180 
TKQTDKGFSG KARLSLEFLV ASIASFIILQ VGSPGLALPF VKEYFINLGW FFIPFSACVV 

       190        200        210        220        230        240 
VGLGNAVNLT DGLDGLAIVP VMVASLSFAL IAYLSGNINF ADYLQIHYVS GVGELAVLLG 

       250        260        270        280        290        300 
AVFGAGLGFL WFNAPPAAIF MGDTGSLALG GLLGIVSVAT KHEIVLIFIG GLFVLETLSV 

       310        320        330        340        350 
IIQVGWFKLT KKRVFLMAPI HHHFEKKGWT ESQIVVRFWI IAIVLALIGL STLKLR

« Hide

References

[1]Hendrix L., Mohamoud Y., Radune D., Shvartsbeyn A., Daugherty S., Dodson R., Durkin A.S., Harkins D., Huot H., Kothari S.P., Madupu R., Li J., Nelson W.C., Shrivastava S., Giglio M.G., Haft D., Selengut J., Fraser-Ligget C., Seshadri R.
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35685 / KC583.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000524 Genomic DNA. Translation: ABM44543.1.
RefSeqYP_989231.1. NC_008783.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA1UTC8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4684086.
GenomeReviewsGene locus BARBAKC583_0950 in contig CP000524_GR.
KEGGbbk:BARBAKC583_0950.
NMPDRfig|360095.3.peg.554.
PATRIC20538193. VBIBarBac6912_0921.
TIGRBARBAKC583_0950.

Phylogenomic databases

eggNOGCOG0472.
HOGENOMHBG708263.
OMARFWIISM.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycBBAC360095:BARBAKC583_0950-MONOMER.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_BARBK
AccessionPrimary (citable) accession number: A1UTC8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: December 14, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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