Reviewed, UniProtKB/Swiss-Prot A1UTC5 (MURG_BARBK)

Names and origin

Protein names

Recommended name:
    UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
    EC=2.4.1.227
Alternative name(s):
    Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase

Gene names

Name:	murG
Ordered Locus Names:	BARBAKC583_0947

Organism

Bartonella bacilliformis (strain ATCC 35685 / KC583) [Complete proteome] [HAMAP]

Taxonomic identifier

360095 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II) By similarity.
Catalytic activity	UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00033
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00033
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the glycosyltransferase 28 family. MurG subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW lipid glycosylation Inferred from electronic annotation. Source: HAMAP peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	carbohydrate binding Inferred from electronic annotation. Source: InterPro undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 378	378	UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase HAMAP MF_00033		PRO_0000315069

Sequences

	Sequence		Length	Mass (Da)
	A1UTC5-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: DFEF0703476E0C41	FASTA	378	41,792
	10 20 30 40 50 60 MTNKKVVVLV AGGTGGHLFP AEALAVELRQ RGYDVHLATD ERAKRFVRHF DEKHIHIISS 70 80 90 100 110 120 ATLVRHHPFA LIKTFWLLLR GMVQSWILFR KLRPVLVGGF GGYPTVPPVW VAALTGRVTF 130 140 150 160 170 180 IHEQNAVMGR ANRVLATRVN AIASGLLLEN KIHIHKTFVT GNPVREAILK AAEIPYCAST 190 200 210 220 230 240 SKQPFYFLVF GGSQGASAFS RIVPEAVKLL DHDIRERLHI VQQVRGEEID LAKIYQDMGV 250 260 270 280 290 300 QAEVAPFFDN MVEHIARSHF IMSRAGASTV CEIAIIGRPA LLIPYPHALD HDQAANAALL 310 320 330 340 350 360 AARGGAQIML EKDLNAQILS SLLTKFCCEP HSLEQRALAA KKVGKPQATR VLADMAEALI 370 VGRSLLDMKR EFFDENTT

References

[1]

Hendrix L., Mohamoud Y., Radune D., Shvartsbeyn A., Daugherty S., Dodson R., Durkin A.S., Harkins D., Huot H., Kothari S.P., Madupu R., Li J., Nelson W.C., Shrivastava S., Giglio M.G., Haft D., Selengut J., Fraser-Ligget C., Seshadri R. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000524 Genomic DNA. Translation: ABM45600.1.
RefSeq	YP_989228.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1UTC5.
Genome annotation databases
GeneID	4683834.
GenomeReviews	Gene locus BARBAKC583_0947 in contig CP000524_GR.
KEGG	bbk:BARBAKC583_0947.
NMPDR	fig|360095.3.peg.551.
TIGR	BARBAKC583_0947.
Phylogenomic databases
OMA	AKVITED.
Family and domain databases
HAMAP	MF_00033. [Tree]
InterPro	IPR004276. Glyco_trans_28. IPR007235. Glyco_trans_28_C. [Graphical view]
Pfam	PF04101. Glyco_tran_28_C. 1 hit. PF03033. Glyco_transf_28. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MURG_BARBK

Accession

Primary (citable) accession number: A1UTC5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	November 3, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)