A1UTC4 (MURC_BARBK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-N-acetylmuramate--L-alanine ligase
EC=6.3.2.8

Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase

Gene names

Name:	murC
Ordered Locus Names:	BARBAKC583_0946

Organism

Bartonella bacilliformis (strain ATCC 35685 / KC583) [Complete proteome] [HAMAP]

Taxonomic identifier

360095 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	475 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cell wall formation By similarity. HAMAP MF_00046
Catalytic activity	ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP MF_00046
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00046
Subcellular location	Cytoplasm By similarity HAMAP MF_00046.
Sequence similarities	Belongs to the MurCDEF family.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW UDP-N-acetylmuramate-L-alanine ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 475	475	UDP-N-acetylmuramate--L-alanine ligase HAMAP MF_00046		PRO_1000004311
Regions
	Nucleotide binding	114 – 120	7	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A1UTC4 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 5F352280557E34DF	FASTA	475	52,080
	10 20 30 40 50 60 MKIPLNIGLI HFVGIGGIGM SGIAEVLHNL GYKIQGSDQA NNTNIERLRS KGINVHIGHQ 70 80 90 100 110 120 AKNLGEAEVV VISTAIKKTN PEYIAAKEKH LPVVKRAEML AELMRFRQAI AIGGTHGKTT 130 140 150 160 170 180 TTSMVAALLD AGNFDPMVIN GGIINAYGTN ARMGNGNWMV VEADESDGTF LKLPADIVVV 190 200 210 220 230 240 TNIDSEHLDH YGSFDAVRES FRQFVENVPF YGFAVMCLDH PEVQTLASRI DDRWVITYGA 250 260 270 280 290 300 NPQADVRFLN FSMKNKKAHF DVLIRSRKTG IQTELRDLVL PMSGKHNVSN ATAAIAIAHE 310 320 330 340 350 360 LGISDEVIRK GLAEFGGVKR RFTQTGSWRG IDVFDDYGHH PVEIKAVLRA ARESTNGQVI 370 380 390 400 410 420 AIAQPHRYSR LCNLFDDFTT CFNDADTIMI APVYAAGEEP ITGFGSKELV EHIQMASHCD 430 440 450 460 470 VRLIDDLEDV VSIVSTVAKS GDYVVFLGAG SITQWAYALP KRLAELDNND EFSAN

References

[1]

Hendrix L., Mohamoud Y., Radune D., Shvartsbeyn A., Daugherty S., Dodson R., Durkin A.S., Harkins D., Huot H., Kothari S.P., Madupu R., Li J., Nelson W.C., Shrivastava S., Giglio M.G., Haft D., Selengut J., Fraser-Ligget C., Seshadri R. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35685 / KC583.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000524 Genomic DNA. Translation: ABM44659.1.
RefSeq	YP_989227.1. NC_008783.1.
3D structure databases
ProteinModelPortal	A1UTC4.
ModBase	Search...
Protein-protein interaction databases
STRING	A1UTC4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4684115.
GenomeReviews	Gene locus BARBAKC583_0946 in contig CP000524_GR.
KEGG	bbk:BARBAKC583_0946.
NMPDR	fig|360095.3.peg.550.
PATRIC	20538185. VBIBarBac6912_0917.
TIGR	BARBAKC583_0946.
Phylogenomic databases
eggNOG	COG0773.
HOGENOM	HBG476594.
OMA	YQPHRYS.
ProtClustDB	PRK00421.
Enzyme and pathway databases
BioCyc	BBAC360095:BARBAKC583_0946-MONOMER.
Family and domain databases
HAMAP	MF_00046. MurC. [Tree]
InterPro	IPR004101. Mur_ligase_C. IPR013221. Mur_ligase_cen. IPR000713. Mur_ligase_N. IPR016040. NAD(P)-bd_dom. IPR005758. UDP-N-AcMur_Ala_ligase. [Graphical view]
Gene3D	G3DSA:3.90.190.20. Mur_ligase_C. 1 hit. G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K01924.
PANTHER	PTHR23135:SF5. PTHR23135:SF5. 1 hit.
Pfam	PF01225. Mur_ligase. 1 hit. PF02875. Mur_ligase_C. 1 hit. PF08245. Mur_ligase_M. 1 hit. [Graphical view]
SUPFAM	SSF53244. Mur_ligase_C. 1 hit. SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMs	TIGR01082. MurC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MURC_BARBK

Accession

Primary (citable) accession number: A1UTC4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program