Reviewed, UniProtKB/Swiss-Prot A1UTA5 (TYSY_BARBK)

Names and origin

Protein names

Recommended name:
    Thymidylate synthase
      Short name=TS
      Short name=TSase
    EC=2.1.1.45

Gene names

Name:	thyA
Ordered Locus Names:	BARBAKC583_0926

Organism

Bartonella bacilliformis (strain ATCC 35685 / KC583) [Complete proteome] [HAMAP]

Taxonomic identifier

360095 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Provides the sole de novo source of dTMP for DNA biosynthesis By similarity.
Catalytic activity	5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP MF_00008
Pathway	Pyrimidine metabolism; dTTP biosynthesis. HAMAP MF_00008
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the thymidylate synthase family. Bacterial-type thyA subfamily.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dTMP biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	thymidylate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Thymidylate synthase HAMAP MF_00008		PRO_1000000579
Sites
	Active site	146	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1UTA5-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 4DE5FBF330C05B7A	FASTA	264	30,130
	10 20 30 40 50 60 MKAYLDLLSH VLNNGTDRSD RTGVGTRSVF GYQMRFNLQE GFPLLTTKKL HLRSIIYELL 70 80 90 100 110 120 WFLKGDTNIA WLKEHGVSIW DEWADKDGNL GPVYGYQWRS WPSSDGRYID QISNLLAMIN 130 140 150 160 170 180 HNPNSRRLIV TAWNPALIDE MALPPCHCLF QFQVANGKLS CQLYQRSADI FLGVPFNIAS 190 200 210 220 230 240 YALLTMMIAQ VTGLKVGDFI HTLGDAHLYS NHFEQAKQQL SRTPGILPLI RINPKVTDLF 250 260 SFQFEDFELL NYEAQPHIKA PVAV

References

[1]

Hendrix L., Mohamoud Y., Radune D., Shvartsbeyn A., Daugherty S., Dodson R., Durkin A.S., Harkins D., Huot H., Kothari S.P., Madupu R., Li J., Nelson W.C., Shrivastava S., Giglio M.G., Haft D., Selengut J., Fraser-Ligget C., Seshadri R. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000524 Genomic DNA. Translation: ABM45103.1.
RefSeq	YP_989208.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1UTA5.
Genome annotation databases
GeneID	4684801.
GenomeReviews	Gene locus BARBAKC583_0926 in contig CP000524_GR.
KEGG	bbk:BARBAKC583_0926.
NMPDR	fig|360095.3.peg.531.
TIGR	BARBAKC583_0926.
Phylogenomic databases
OMA	ADIPRMK.
Family and domain databases
HAMAP	MF_00008. [Tree]
InterPro	IPR000398. Thymidylat_synth_C. [Graphical view]
Gene3D	G3DSA:3.30.572.10. Thymidylat_synth_C. 1 hit.
PANTHER	PTHR11549:SF2. Thymidylat_synth_C. 1 hit.
Pfam	PF00303. Thymidylat_synt. 1 hit. [Graphical view]
PRINTS	PR00108. THYMDSNTHASE.
ProDom	PD001180. Thymidylat_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR03284. thym_sym. 1 hit.
PROSITE	PS00091. THYMIDYLATE_SYNTHASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYSY_BARBK

Accession

Primary (citable) accession number: A1UTA5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	November 3, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)