Reviewed, UniProtKB/Swiss-Prot A1UT97 (ILVC_BARBK)

Names and origin

Protein names

Recommended name:
    Ketol-acid reductoisomerase
    EC=1.1.1.86
Alternative name(s):
    Acetohydroxy-acid isomeroreductase
    Alpha-keto-beta-hydroxylacil reductoisomerase

Gene names

Name:	ilvC
Ordered Locus Names:	BARBAKC583_0917

Organism

Bartonella bacilliformis (strain ATCC 35685 / KC583) [Complete proteome] [HAMAP]

Taxonomic identifier

360095 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435 (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435 Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435
Sequence similarities	Belongs to the ketol-acid reductoisomerase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	isoleucine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW valine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	binding Inferred from electronic annotation. Source: InterPro ketol-acid reductoisomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 339	339	Ketol-acid reductoisomerase HAMAP MF_00435		PRO_1000050480
Sites
	Active site	108	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	A1UT97-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 7AB4449FF07D0EE5	FASTA	339	37,357
	10 20 30 40 50 60 MRVYYDCDVN VNLIKEKKVA IVGYGAQGHA HALNLKDSGV QNVRIALHSG SMTTKKAEAD 70 80 90 100 110 120 GFEVMSVAEA VQWADFIMIA TPDELQADIY KEHIHDHLRD GAAISFAHGL SIHFGLIKVK 130 140 150 160 170 180 KTVDVVMIAP KGAGRAVRSE YQHGRGIPCL IAVEQDVSGN AHDLALSYAC GIGGGRSGIM 190 200 210 220 230 240 KTTFREECET DLFGEQAVLC GGLVELIRAG FETLTEAGYA PEMAYFECLH EIKIIADLIY 250 260 270 280 290 300 ECGIANMNYS ISNTAEWGEY VSGPRVITHE TKAEMKRILK DIQTGKFTSE WIQEYRAGAA 310 320 330 RFKDMRRLNS NHLIEQTGDK IRSMMALTKS SAPVDKKHS

References

[1]

Hendrix L., Mohamoud Y., Radune D., Shvartsbeyn A., Daugherty S., Dodson R., Durkin A.S., Harkins D., Huot H., Kothari S.P., Madupu R., Li J., Nelson W.C., Shrivastava S., Giglio M.G., Haft D., Selengut J., Fraser-Ligget C., Seshadri R. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000524 Genomic DNA. Translation: ABM44512.1.
RefSeq	YP_989200.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4683917.
GenomeReviews	Gene locus BARBAKC583_0917 in contig CP000524_GR.
KEGG	bbk:BARBAKC583_0917.
NMPDR	fig|360095.3.peg.521.
TIGR	BARBAKC583_0917.
Phylogenomic databases
OMA	A1UT97. AHGFNIR.
Family and domain databases
HAMAP	MF_00435. [Tree]
InterPro	IPR013023. AcH_isomrdctse. IPR000506. AcH_isomrdctse_C. IPR013116. IlvN. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR21371. AcH_isomrdctse. 1 hit.
Pfam	PF01450. IlvC. 1 hit. PF07991. IlvN. 1 hit. [Graphical view]
TIGRFAMs	TIGR00465. ilvC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ILVC_BARBK

Accession

Primary (citable) accession number: A1UT97

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	June 16, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)