Reviewed, UniProtKB/Swiss-Prot A1UT52 (SYD_BARBK)

Names and origin

Protein names

Recommended name:
    Aspartyl-tRNA synthetase
    EC=6.1.1.12
Alternative name(s):
    Aspartate--tRNA ligase
      Short name=AspRS

Gene names

Name:	aspS
Ordered Locus Names:	BARBAKC583_0868

Organism

Bartonella bacilliformis (strain ATCC 35685 / KC583) [Complete proteome] [HAMAP]

Taxonomic identifier

360095 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	596 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). HAMAP MF_00044
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aspartyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP aspartate-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 596	596	Aspartyl-tRNA synthetase HAMAP MF_00044		PRO_1000006638

Sequences

	Sequence		Length	Mass (Da)
	A1UT52-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: CCA6AF3F11566C6E	FASTA	596	67,562
	10 20 30 40 50 60 MHRYRSHNCA ALRKCDVGTQ VRLSGWVHRV RDHGGILFVD LRDHFGITQI VVNPDSSAFQ 70 80 90 100 110 120 IMEKVRSEWV ICVDGKVCAR SDEVINTTLP TGEIEIFADE IEILSKSDEL PLPVFGEPDY 130 140 150 160 170 180 PEDIRLKYRF LDLRRVTMHK NIMRRTEIIS SIRRHMQDSG FTEFTTPLLT ASSPEGARDF 190 200 210 220 230 240 LVPSRIHQGK FYALPQAPQQ YKQLLMMSGF DRYFQIAPCF RDEDPRADRL PGEFYQLDIE 250 260 270 280 290 300 MSFVEQEDVL ATMEPIIRSV FEEFSDGKLV TQSFPRISYD EAMRKYGSDK PDLRNPIIIE 310 320 330 340 350 360 DVSQHFYDSD FKVFAQILAN NENAQVWAIP AKTGGNRAFC DRMNGWAQGE GQPGLGYIFW 370 380 390 400 410 420 RKEGENFEGA GPIAKNIGEQ RTEAIRTQLG LKEGDACFFV AGDPKKFASF AGASRTRIGE 430 440 450 460 470 480 ELDLIDSKCF SFAWIVDFPF FEWNEDEKKI DFAHNPFSMP QGGMNAVDSQ DPLTIKAFQY 490 500 510 520 530 540 DLVCNGYEIA SGGIRNHSPE MMLKVFNLAG LSREIVEERF GGLYRAFHYG APPHGGMAAG 550 560 570 580 590 VDRIVMLLQG VKNLREISLF PMNQQALDLL MSAPSDVSAT QLNDLGIRIF PKVNNA

References

[1]

Hendrix L., Mohamoud Y., Radune D., Shvartsbeyn A., Daugherty S., Dodson R., Durkin A.S., Harkins D., Huot H., Kothari S.P., Madupu R., Li J., Nelson W.C., Shrivastava S., Giglio M.G., Haft D., Selengut J., Fraser-Ligget C., Seshadri R. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000524 Genomic DNA. Translation: ABM44906.1.
RefSeq	YP_989155.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1UT52.
Genome annotation databases
GeneID	4685154.
GenomeReviews	Gene locus BARBAKC583_0868 in contig CP000524_GR.
KEGG	bbk:BARBAKC583_0868.
NMPDR	fig|360095.3.peg.876.
TIGR	BARBAKC583_0868.
Phylogenomic databases
OMA	YQLDVEM.
Family and domain databases
HAMAP	MF_00044. [Tree]
InterPro	IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II_cons-reg. IPR002312. Asp-tRNA-synth_IIb. IPR020564. Asp-tRNA-synth_IIb_bac-type. IPR004524. Asp-tRNA-synth_IIb_bac/mt. IPR018153. Asp-tRNA-synth_IIb_C_bac/mt. IPR004115. GAD_dom. IPR012340. NA-bd_OB-fold. IPR004365. NA_bd_OB_tRNA-helicase. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
PANTHER	PTHR22594. aa-tRNA-synt_II. 1 hit. PTHR22594:SF5. AspS_bac. 1 hit.
Pfam	PF02938. GAD. 1 hit. PF00152. tRNA-synt_2. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
PRINTS	PR01042. TRNASYNTHASP.
TIGRFAMs	TIGR00459. aspS_bact. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYD_BARBK

Accession

Primary (citable) accession number: A1UT52

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	November 3, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)