Reviewed, UniProtKB/Swiss-Prot A1UT24 (PYRB_BARBK)

Names and origin

Protein names

Recommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	BARBAKC583_0839

Organism

Bartonella bacilliformis (strain ATCC 35685 / KC583) [Complete proteome] [HAMAP]

Taxonomic identifier

360095 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 2/6. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000301556

Sequences

	Sequence		Length	Mass (Da)
	A1UT24-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: DC5AFEACE7754431	FASTA	321	35,375
	10 20 30 40 50 60 MTQNTPFPIF PHRHLLGIKG LTLQDLTTLL DRADANVTLY QKNDKKKSIL HGRTQINLFF 70 80 90 100 110 120 ESSTRTQSSF ELAGKRLGAD VMNMIISNSS VKKGETLIDT ATTLNAMNPD ILVIRHNCAG 130 140 150 160 170 180 AASLLAQKID CCVINAGDGA HEHPTQALLD ALTIRRTKGR IEGLTVAICG DILHSRVARS 190 200 210 220 230 240 NIISLNTLGA RVRVVAPSTL LPTGIEDMGV EVFHTMQEGL KGADVVMMLR LQLERMTGAF 250 260 270 280 290 300 IPSIREYFYH FGLHKENLIY AKNDCIIMHP GPINRGVEIA SDIADGTRSM IHTQVEMGIA 310 320 VRMAIMEALL DPRHDYNGEK K

References

[1]

Hendrix L., Mohamoud Y., Radune D., Shvartsbeyn A., Daugherty S., Dodson R., Durkin A.S., Harkins D., Huot H., Kothari S.P., Madupu R., Li J., Nelson W.C., Shrivastava S., Giglio M.G., Haft D., Selengut J., Fraser-Ligget C., Seshadri R. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000524 Genomic DNA. Translation: ABM44756.1.
RefSeq	YP_989127.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4685106.
GenomeReviews	Gene locus BARBAKC583_0839 in contig CP000524_GR.
KEGG	bbk:BARBAKC583_0839.
NMPDR	fig|360095.3.peg.849.
TIGR	BARBAKC583_0839.
Phylogenomic databases
OMA	A1UT24. CHANIIN.
Family and domain databases
HAMAP	MF_00001. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002082. Aspartate_carbamoyltransf_euk. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_BARBK

Accession

Primary (citable) accession number: A1UT24

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	February 6, 2007
Last modified:	June 16, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)