Reviewed, UniProtKB/Swiss-Prot A1USJ5 (GCH1_BARBK)

Names and origin

Protein names

Recommended name:
    GTP cyclohydrolase 1
    EC=3.5.4.16
Alternative name(s):
    GTP cyclohydrolase I
      Short name=GTP-CH-I

Gene names

Name:	folE
Ordered Locus Names:	BARBAKC583_0644

Organism

Bartonella bacilliformis (strain ATCC 35685 / KC583) [Complete proteome] [HAMAP]

Taxonomic identifier

360095 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP MF_00223
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP MF_00223
Subunit structure	Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.
Sequence similarities	Belongs to the GTP cyclohydrolase I family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	GTP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	GTP cyclohydrolase 1 HAMAP MF_00223		PRO_1000043664
Sites
	Metal binding	95	1	Zinc By similarity
	Metal binding	98	1	Zinc By similarity
	Metal binding	166	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1USJ5-1 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 7B9F5A8A960CC73D	FASTA	206	23,191
	10 20 30 40 50 60 MHSAVEKVAE DLSLSRENLS LEEVEKAIRT LLLWVGENPD REGLLETPKR IAKVYKELFS 70 80 90 100 110 120 GYGESVDEIL GVVFEEVAGY DEPVIVKDIF FYSHCEHHMI PIIGKAHVAY LPDKKIVGLS 130 140 150 160 170 180 KIARVVDVFA HRLQTQETMT AQVANSLKKY LKPRGLAVLI EAEHMCMAMR GVQKQGAATI 190 200 TTSFHGYYKK DQVAQANFMT ITRGIR

References

[1]

Hendrix L., Mohamoud Y., Radune D., Shvartsbeyn A., Daugherty S., Dodson R., Durkin A.S., Harkins D., Huot H., Kothari S.P., Madupu R., Li J., Nelson W.C., Shrivastava S., Giglio M.G., Haft D., Selengut J., Fraser-Ligget C., Seshadri R. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000524 Genomic DNA. Translation: ABM44443.1.
RefSeq	YP_988948.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A1USJ5.
Genome annotation databases
GeneID	4684210.
GenomeReviews	Gene locus BARBAKC583_0644 in contig CP000524_GR.
KEGG	bbk:BARBAKC583_0644.
NMPDR	fig|360095.3.peg.324.
TIGR	BARBAKC583_0644.
Phylogenomic databases
OMA	GVQKQGA.
Family and domain databases
HAMAP	MF_00223. [Tree]
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
PANTHER	PTHR11109. GTP_cyclohydro_I. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
ProDom	PD003330. GTP_cyclohydroI. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00063. folE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH1_BARBK

Accession

Primary (citable) accession number: A1USJ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	November 3, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)