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Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Bartonella bacilliformis (strain ATCC 35685 / KC583)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei241ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBBAC360095:G1G7W-557-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 1UniRule annotation
Short name:
GluRS 1UniRule annotation
Gene namesi
Name:gltX1UniRule annotation
Ordered Locus Names:BARBAKC583_0600
OrganismiBartonella bacilliformis (strain ATCC 35685 / KC583)
Taxonomic identifieri360095 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi
  • UP000000643 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000018731 – 476Glutamate--tRNA ligase 1Add BLAST476

Proteomic databases

PRIDEiA1USF5

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi360095.BARBAKC583_0600

Structurei

3D structure databases

ProteinModelPortaliA1USF5
SMRiA1USF5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi9 – 19"HIGH" regionUniRule annotationAdd BLAST11
Motifi238 – 242"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiAYYAFDT
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A1USF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVITRFAPS PTGFLHIGGA RTALFNWLYA KHHGGKMLLR IEDTDRERST
60 70 80 90 100
DAAVKAIING LHWIGLSYDG DPISQFERTE RHREVAEQLV KDGKAYYCYA
110 120 130 140 150
SPEELAEMRE SARAEGRPPH YDGHWRDRDI SEAPKGIKPV IRIKAPKEGA
160 170 180 190 200
TIVRDRVQGD VLFPNKDLDD FIILRSDGTP TYMLAVVVDD HDMGITHIIR
210 220 230 240 250
GDDHLTNAAR QTIIFNAMGW KIPVMAHIPL IHGEDGAKLS KRHGALGVDA
260 270 280 290 300
YRAMGYLPAA LRNYLVRLGW SHGNDEIIST EDMISWFDID DINKGAARLD
310 320 330 340 350
FKKLNAINGH YIRMSTDQDL FDSTLSILPE IESGLEIIDK LDKKHRAQFL
360 370 380 390 400
AAIPHIKERS KTLLELIDGA SFIFTKQPLL LDEKAKMLLN EDGQAILKSI
410 420 430 440 450
YPILESCSYW DTNTLDEALR HYAQKQELKF GTIAQPLRAA LTGRATSPGV
460 470
FDVLVLLGRN ESLNRINQQI NTTKCS
Length:476
Mass (Da):53,541
Last modified:February 6, 2007 - v1
Checksum:i82EFF2AFAB970585
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000524 Genomic DNA Translation: ABM44719.1
RefSeqiWP_005766777.1, NC_008783.1

Genome annotation databases

EnsemblBacteriaiABM44719; ABM44719; BARBAKC583_0600
GeneIDi4684979
KEGGibbk:BARBAKC583_0600
PATRICifig|360095.6.peg.586

Similar proteinsi

Entry informationi

Entry nameiSYE1_BARBK
AccessioniPrimary (citable) accession number: A1USF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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