A1USE9 (A1USE9_BARBK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Lipid-A-disaccharide synthase EMBL ABM44923.1
EC=2.4.1.182 EMBL ABM44923.1

Gene names

Name:	lpxB EMBL ABM44923.1
Ordered Locus Names:	BARBAKC583_0594

Organism

Bartonella bacilliformis (strain ATCC 35685 / KC583) [Complete proteome] [HAMAP]

Taxonomic identifier

360095 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. SAAS SAAS003835

Ontologies

Keywords
Biological process	Lipid A biosynthesis SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase SAAS SAAS003835 EMBL ABM44923.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A1USE9 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: E7D99068896E07EB	FASTA	394	44,320
	10 20 30 40 50 60 MTDNCSLKIA VIAGEESGDL LGADLISSLS HQTGCKIHLI GVGGKHLEAL GLKSIFNSDD 70 80 90 100 110 120 ISLIGLWAVL KKLLLLLMHI RNVSRFIARE KPDCLIIIDS PDFTHRVAKK VRILEPSIPI 130 140 150 160 170 180 IKYVAPTVWA WRPERAKAMR KFVDHILAVF PFEEKIMKNL GGPPLTYVGH RLLAYPPLLK 190 200 210 220 230 240 IQSQKECLDT QRETFTMVVL PGSRSLEVRY LMPVFGETVA IAKQRIPNLR VILPTLPHLI 250 260 270 280 290 300 DEVRYFAQNW KNEVEIVVGE DAKWHAFTDA DVALAALGTV SLELALAKIP MVLCYKLDCL 310 320 330 340 350 360 FKFFLFPKTT LWSAALPNII ADKPAIPEYF NEFLRPGMLA RQVEQLLHNH SLRQVQLDAF 370 380 390 DVMKKKMQTE LSSGVIASQT VINILKNKSR HLGL

References

[1]

Hendrix L., Mohamoud Y., Radune D., Shvartsbeyn A., Daugherty S., Dodson R., Durkin A.S., Harkins D., Huot H., Kothari S.P., Madupu R., Li J., Nelson W.C., Shrivastava S., Giglio M.G., Haft D., Selengut J., Fraser-Ligget C., Seshadri R. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000524 Genomic DNA. Translation: ABM44923.1.
RefSeq	YP_988902.1. NC_008783.1.
3D structure databases
ProteinModelPortal	A1USE9.
ModBase	Search...
Protein-protein interaction databases
STRING	A1USE9.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4684401.
GenomeReviews	Gene locus BARBAKC583_0594 in contig CP000524_GR.
KEGG	bbk:BARBAKC583_0594.
NMPDR	fig|360095.3.peg.278.
PATRIC	20537473. VBIBarBac6912_0580.
TIGR	BARBAKC583_0594.
Phylogenomic databases
eggNOG	COG0763.
HOGENOM	HBG584837.
OMA	PDFNLGL.
ProtClustDB	PRK00025.
Family and domain databases
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A1USE9_BARBK

Accession

Primary (citable) accession number: A1USE9

Entry history

Integrated into UniProtKB/TrEMBL:	February 6, 2007
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)