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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Bartonella bacilliformis (strain ATCC 35685 / KC583)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

Cofactori

FADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 186FADUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciBBAC360095:GHRY-551-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
Gene namesi
Name:trmFOUniRule annotation
Synonyms:gid
Ordered Locus Names:BARBAKC583_0551
OrganismiBartonella bacilliformis (strain ATCC 35685 / KC583)
Taxonomic identifieri360095 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi
  • UP000000643 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 464464Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOPRO_1000063911Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360095.BARBAKC583_0551.

Structurei

3D structure databases

ProteinModelPortaliA1USB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QXI. Bacteria.
COG1206. LUCA.
HOGENOMiHOG000252054.
KOiK04094.
OMAiDYLNCPM.
OrthoDBiEOG6J74VT.

Family and domain databases

Gene3Di3.50.50.60. 4 hits.
HAMAPiMF_01037. TrmFO.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR002218. MnmG-rel.
IPR020595. MnmG-rel_CS.
IPR004417. TrmFO.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
PROSITEiPS01281. GIDA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1USB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNKLNLPIH IIGGGLAGSE ASWQIAQLGI PVILHEMRPQ RLSEAHKTDK
60 70 80 90 100
LAELVCSNSF RSDDSLTNAV GLLHAEMRLA KSLIMKAADA NKVPAGSALA
110 120 130 140 150
VDRDGFSQTV TESLENHPLI TIKREEIHDI PENWHNVIIA TGPLTSPALA
160 170 180 190 200
YAIQAVTGTE ALSFFDAIAP IIYTDSINMN ICWYQSRYDK IGPGGTGKDY
210 220 230 240 250
INCPLDKEQY EAFIQALKDG EKIEFREFEN VPYFDGCLPI EVMAERGVET
260 270 280 290 300
LRHGPMKPMG LTNTHTPKVK AYAIVQLRQD NMLGTLYNMV GFQTKLKYSE
310 320 330 340 350
QVRIFRTIPG LEKAEFARLG GLHRNTYLDS PTILDETLRL KKKPQLRFAG
360 370 380 390 400
QITGCEGYVE SSAIGLLAGR FAAAEYNNTY PSLPPKTTAF GALLNHITSG
410 420 430 440 450
YIVTQETEKH SFQPMNINFG LFPPIDSTNH QRKTMQYKEK KLAKRQAIVE
460
RALNDCTQWL NGLK
Length:464
Mass (Da):51,693
Last modified:February 6, 2007 - v1
Checksum:iC9B6E37A99906270
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000524 Genomic DNA. Translation: ABM44898.1.
RefSeqiWP_005766693.1. NC_008783.1.

Genome annotation databases

EnsemblBacteriaiABM44898; ABM44898; BARBAKC583_0551.
GeneIDi4684244.
KEGGibbk:BARBAKC583_0551.
PATRICi20537379. VBIBarBac6912_0537.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000524 Genomic DNA. Translation: ABM44898.1.
RefSeqiWP_005766693.1. NC_008783.1.

3D structure databases

ProteinModelPortaliA1USB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi360095.BARBAKC583_0551.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABM44898; ABM44898; BARBAKC583_0551.
GeneIDi4684244.
KEGGibbk:BARBAKC583_0551.
PATRICi20537379. VBIBarBac6912_0537.

Phylogenomic databases

eggNOGiENOG4107QXI. Bacteria.
COG1206. LUCA.
HOGENOMiHOG000252054.
KOiK04094.
OMAiDYLNCPM.
OrthoDBiEOG6J74VT.

Enzyme and pathway databases

BioCyciBBAC360095:GHRY-551-MONOMER.

Family and domain databases

Gene3Di3.50.50.60. 4 hits.
HAMAPiMF_01037. TrmFO.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR002218. MnmG-rel.
IPR020595. MnmG-rel_CS.
IPR004417. TrmFO.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
PROSITEiPS01281. GIDA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35685 / KC583.

Entry informationi

Entry nameiTRMFO_BARBK
AccessioniPrimary (citable) accession number: A1USB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 6, 2007
Last modified: January 20, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.