A1US93 (KDSA_BARBK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-dehydro-3-deoxyphosphooctonate aldolase
EC=2.5.1.55

Alternative name(s):
3-deoxy-D-manno-octulosonic acid 8-phosphate synthase
KDO-8-phosphate synthase
Short name=KDO 8-P synthase
Short name=KDOPS
Phospho-2-dehydro-3-deoxyoctonate aldolase

Gene names

Name:	kdsA
Ordered Locus Names:	BARBAKC583_0531

Organism

Bartonella bacilliformis (strain ATCC 35685 / KC583) [Complete proteome] [HAMAP]

Taxonomic identifier

360095 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	282 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate. HAMAP MF_00056
Pathway	Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3. HAMAP MF_00056 Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP MF_00056
Subcellular location	Cytoplasm By similarity HAMAP MF_00056.
Sequence similarities	Belongs to the KdsA family.

Ontologies

Keywords
Biological process	Lipopolysaccharide biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipopolysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-deoxy-8-phosphooctulonate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 282	282	2-dehydro-3-deoxyphosphooctonate aldolase HAMAP MF_00056		PRO_0000304432

Sequences

	Sequence		Length	Mass (Da)
	A1US93 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: B6B35E0B690E9E73	FASTA	282	30,481
	10 20 30 40 50 60 MSQPNVSVKV GNVVFSNKAP LSLIVGPCQI ESRDHAFEMA GRIKAIADQA GIGFVYKSSY 70 80 90 100 110 120 DKANRTSLSA ARGIGLEKAI AIFADLKKEF GFPILTDVHT EEQCRAVSSV VDVLQIPAFL 130 140 150 160 170 180 CRQTDLLVAA AKTGCVINIK KGQFLAPWDM ENVLKKVTQS GNPDVMLCER GTSFGYNRLV 190 200 210 220 230 240 SDMRSLPIMS SFGAPVIFDA THSVQEPGGK GDSSGGQRQF VEILARAAVA VGVAGIFLET 250 260 270 280 HQDPDNAPSD GANMIEIDNL QRLIEILMNF DRLTKNELNI HA

References

[1]

Hendrix L., Mohamoud Y., Radune D., Shvartsbeyn A., Daugherty S., Dodson R., Durkin A.S., Harkins D., Huot H., Kothari S.P., Madupu R., Li J., Nelson W.C., Shrivastava S., Giglio M.G., Haft D., Selengut J., Fraser-Ligget C., Seshadri R. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35685 / KC583.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000524 Genomic DNA. Translation: ABM45460.1.
RefSeq	YP_988846.1. NC_008783.1.
3D structure databases
ProteinModelPortal	A1US93.
ModBase	Search...
Protein-protein interaction databases
STRING	A1US93.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4684922.
GenomeReviews	Gene locus BARBAKC583_0531 in contig CP000524_GR.
KEGG	bbk:BARBAKC583_0531.
NMPDR	fig|360095.3.peg.220.
PATRIC	20537335. VBIBarBac6912_0515.
TIGR	BARBAKC583_0531.
Phylogenomic databases
eggNOG	COG2877.
HOGENOM	HBG575990.
OMA	ESRDHAF.
ProtClustDB	PRK05198.
Enzyme and pathway databases
BioCyc	BBAC360095:BARBAKC583_0531-MONOMER.
Family and domain databases
HAMAP	MF_00056. KDO8P_synth. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006269. KDO8P_synthase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01627.
PANTHER	PTHR21057:SF2. KDO8P_synthase. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01362. KDO8P_synth. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KDSA_BARBK

Accession

Primary (citable) accession number: A1US93

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	February 6, 2007
Last modified:	January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program