A1US90 (TPIS_BARBK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Triosephosphate isomerase
Short name=TIM
EC=5.3.1.1

Alternative name(s):
Triose-phosphate isomerase

Gene names

Name:	tpiA
Ordered Locus Names:	BARBAKC583_0528

Organism

Bartonella bacilliformis (strain ATCC 35685 / KC583) [Complete proteome] [HAMAP]

Taxonomic identifier

360095 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glyceraldehyde 3-phosphate = glycerone phosphate. HAMAP MF_00147_B
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00147_B Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. HAMAP MF_00147_B
Subunit structure	Homodimer By similarity. HAMAP MF_00147_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00147_B.
Sequence similarities	Belongs to the triosephosphate isomerase family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis Pentose shunt
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	triose-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	Triosephosphate isomerase HAMAP MF_00147_B		PRO_0000307433
Sites
	Active site	99	1	Electrophile By similarity
	Active site	169	1	Proton acceptor By similarity
	Binding site	12	1	Substrate By similarity
	Binding site	14	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1US90 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 57C7DCA1C634B020	FASTA	254	27,431
	10 20 30 40 50 60 MTSSIRPLLA GNWKMNGTSE SLRELRAIAS GIDSDRDRCF EALVCVPATL LSRASDILSD 70 80 90 100 110 120 ENIFLGGQDC HFNDSGPHTG DISACMLKEA GASHVILGHS ERRTDYRESD AIVCAKVKAA 130 140 150 160 170 180 WRAGLVALIC IGETLEEREN NTVLDVLAQQ LKGSVPAGAM DHNTVIAYEP RWAIGTGKTP 190 200 210 220 230 240 TSEDIAQVHG FIRKEVSHRF GDEGHKIRLL YGGSVKPSNA SELLETSHVN GALIGGASLK 250 ATDFLTICNI YRKL

References

[1]

Hendrix L., Mohamoud Y., Radune D., Shvartsbeyn A., Daugherty S., Dodson R., Durkin A.S., Harkins D., Huot H., Kothari S.P., Madupu R., Li J., Nelson W.C., Shrivastava S., Giglio M.G., Haft D., Selengut J., Fraser-Ligget C., Seshadri R. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35685 / KC583.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000524 Genomic DNA. Translation: ABM44445.1.
RefSeq	YP_988843.1. NC_008783.1.
3D structure databases
ProteinModelPortal	A1US90.
ModBase	Search...
Protein-protein interaction databases
STRING	A1US90.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4684665.
GenomeReviews	Gene locus BARBAKC583_0528 in contig CP000524_GR.
KEGG	bbk:BARBAKC583_0528.
NMPDR	fig|360095.3.peg.217.
PATRIC	20537329. VBIBarBac6912_0512.
TIGR	BARBAKC583_0528.
Phylogenomic databases
eggNOG	COG0149.
HOGENOM	HBG708281.
OMA	VCVGETQ.
ProtClustDB	PRK00042.
Enzyme and pathway databases
BioCyc	BBAC360095:BARBAKC583_0528-MONOMER.
Family and domain databases
HAMAP	MF_00147_B. TIM_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR022896. TrioseP_Isoase_bac/euk. IPR000652. Triosephosphate_isomerase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01803.
PANTHER	PTHR21139. Triophos_ismrse. 1 hit.
Pfam	PF00121. TIM. 1 hit. [Graphical view]
SUPFAM	SSF51351. Triophos_ismrse. 1 hit.
TIGRFAMs	TIGR00419. Tim. 1 hit.
PROSITE	PS00171. TIM_1. False negative. PS51440. TIM_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TPIS_BARBK

Accession

Primary (citable) accession number: A1US90

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program