A1URW6 (DXS_BARBK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7

Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	BARBAKC583_0400

Organism

Bartonella bacilliformis (strain ATCC 35685 / KC583) [Complete proteome] [HAMAP]

Taxonomic identifier

360095 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	638 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity. HAMAP MF_00315
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: InterPro thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: EC oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 638	638	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_1000019010

Sequences

	Sequence		Length	Mass (Da)
	A1URW6 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: E0F3396E038AEF52	FASTA	638	69,533
	10 20 30 40 50 60 MSRPLTPLLD CVLSPLDLRA LPASDLARLA DELRAEMIDV VSVTGGHLGA GLGVVELTIA 70 80 90 100 110 120 LHYIFNTPDD RIIWDVGHQA YPHKILTGRR DKIRTLRQEG GLSGFTKRSE SIYDPFGAGH 130 140 150 160 170 180 SSTSISAGLG MAMASALKAE ERRNVIAVIG DGAMSAGMAY EAMNNAGALD ARLIVILNDN 190 200 210 220 230 240 DMSIAPPTGA MSAHLARLVS RPSYRHLRER IKLFSKKFPK FFSEQASRSE EFARGFLVGG 250 260 270 280 290 300 TLFDELGFYY VGPIDGHNFE HLLPVLKNVR AYPNGPVLVH VVTHKGKGYA PAEESADKYH 310 320 330 340 350 360 GVNRFDVVTG KQVKAQSTRL SYTKVFSKAL IEEATHDHKI VAITAAMPTG TGLDSFAEKF 370 380 390 400 410 420 SDRMFDVGIA EQHAVTFAAG IACEGYKPFV AIYSTFLQRA YDQIIHDVSI QKLPVRFAID 430 440 450 460 470 480 RAGFVGADGA THAGSFDIVF LATLPEFVVM APSDEVELMH MVRTAAVYDQ GPISFRYPRG 490 500 510 520 530 540 EGIGMDLPQR GEVLEIGKGR VLREGSRVAL VCFGTQLSEV LVAADELAAE GISTTVADAR 550 560 570 580 590 600 FAKPLDKDLM RRLAREHEVF ITIEEGAIGG FGAHVLQFLA QEALLEHGLK VRTLRLPDEY 610 620 630 LNHGSPEKIL SRVGLDAKGI INAVFTSLGY ETRKTLQI

References

[1]

Hendrix L., Mohamoud Y., Radune D., Shvartsbeyn A., Daugherty S., Dodson R., Durkin A.S., Harkins D., Huot H., Kothari S.P., Madupu R., Li J., Nelson W.C., Shrivastava S., Giglio M.G., Haft D., Selengut J., Fraser-Ligget C., Seshadri R. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35685 / KC583.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000524 Genomic DNA. Translation: ABM45122.1.
RefSeq	YP_988719.1. NC_008783.1.
3D structure databases
ProteinModelPortal	A1URW6.
ModBase	Search...
Protein-protein interaction databases
STRING	A1URW6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4683822.
GenomeReviews	Gene locus BARBAKC583_0400 in contig CP000524_GR.
KEGG	bbk:BARBAKC583_0400.
NMPDR	fig|360095.3.peg.448.
PATRIC	20537067. VBIBarBac6912_0383.
TIGR	BARBAKC583_0400.
Phylogenomic databases
eggNOG	COG1154.
HOGENOM	HBG571647.
OMA	DPILYHG.
ProtClustDB	PRK05444.
Enzyme and pathway databases
BioCyc	BBAC360095:BARBAKC583_0400-MONOMER.
Family and domain databases
HAMAP	MF_00315. DXP_synth. [Tree]
InterPro	IPR001017. DH_E1. IPR005477. Dxylulose-5-P_synthase. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K01662.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
TIGRFAMs	TIGR00204. Dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. PS00802. TRANSKETOLASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_BARBK

Accession

Primary (citable) accession number: A1URW6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program