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A1URB3

- DUT_BARBK

UniProt

A1URB3 - DUT_BARBK

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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

dut

Organism
Bartonella bacilliformis (strain ATCC 35685 / KC583)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei96 – 961SubstrateUniRule annotation
Binding sitei110 – 1101Substrate; via amide nitrogen and carbonyl oxygenUniRule annotation

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. dUMP biosynthetic process Source: UniProtKB-UniPathway
  2. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciBBAC360095:GHRY-178-MONOMER.
UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
Short name:
dUTPaseUniRule annotation
Alternative name(s):
dUTP pyrophosphataseUniRule annotation
Gene namesi
Name:dutUniRule annotation
Ordered Locus Names:BARBAKC583_0178
OrganismiBartonella bacilliformis (strain ATCC 35685 / KC583)
Taxonomic identifieri360095 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000000643: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 177177Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_1000015445Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360095.BARBAKC583_0178.

Structurei

3D structure databases

ProteinModelPortaliA1URB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni83 – 853Substrate bindingUniRule annotation
Regioni100 – 1023Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the dUTPase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0756.
HOGENOMiHOG000028968.
KOiK01520.
OMAiEPMERIA.
OrthoDBiEOG689HXK.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00116. dUTPase_bact.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR00576. dut. 1 hit.

Sequencei

Sequence statusi: Complete.

A1URB3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLQDAHNSS SPSQKLPLWV QCLEHGQGLG LPHYATEGSA GLDLRAALPE
60 70 80 90 100
NESITLSPGQ RALIPTGLIF HLSPGFEAQI RPRSGLALKN GITCLNTPGT
110 120 130 140 150
IDSDYRGEVK VLLINLGQED FIIERGMRIA QTVIAPVTQV EVRLLDPNSD
160 170
LTSSQTDLSN QPNTGRGTGG FGSTGQK
Length:177
Mass (Da):18,854
Last modified:February 6, 2007 - v1
Checksum:i0C5B9F6B5AE92E09
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000524 Genomic DNA. Translation: ABM45604.1.
RefSeqiYP_988516.1. NC_008783.1.

Genome annotation databases

EnsemblBacteriaiABM45604; ABM45604; BARBAKC583_0178.
GeneIDi4683934.
KEGGibbk:BARBAKC583_0178.
PATRICi20536629. VBIBarBac6912_0176.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000524 Genomic DNA. Translation: ABM45604.1 .
RefSeqi YP_988516.1. NC_008783.1.

3D structure databases

ProteinModelPortali A1URB3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360095.BARBAKC583_0178.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM45604 ; ABM45604 ; BARBAKC583_0178 .
GeneIDi 4683934.
KEGGi bbk:BARBAKC583_0178.
PATRICi 20536629. VBIBarBac6912_0176.

Phylogenomic databases

eggNOGi COG0756.
HOGENOMi HOG000028968.
KOi K01520.
OMAi EPMERIA.
OrthoDBi EOG689HXK.

Enzyme and pathway databases

UniPathwayi UPA00610 ; UER00666 .
BioCyci BBAC360095:GHRY-178-MONOMER.

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
HAMAPi MF_00116. dUTPase_bact.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
TIGRFAMsi TIGR00576. dut. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35685 / KC583.

Entry informationi

Entry nameiDUT_BARBK
AccessioniPrimary (citable) accession number: A1URB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3