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A1UR86

- RUVC_BARBK

UniProt

A1UR86 - RUVC_BARBK

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Protein
Crossover junction endodeoxyribonuclease RuvC
Gene
ruvC, BARBAKC583_0151
Organism
Bartonella bacilliformis (strain ATCC 35685 / KC583)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group By similarity.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi11 – 111Magnesium By similarity
Metal bindingi71 – 711Magnesium By similarity
Metal bindingi143 – 1431Magnesium By similarity
Metal bindingi146 – 1461Magnesium By similarity

GO - Molecular functioni

  1. crossover junction endodeoxyribonuclease activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. nucleic acid binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. DNA recombination Source: UniProtKB-HAMAP
  2. DNA repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciBBAC360095:GHRY-151-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endodeoxyribonuclease RuvC (EC:3.1.22.4)
Alternative name(s):
Holliday junction nuclease RuvC
Holliday junction resolvase RuvC
Gene namesi
Name:ruvC
Ordered Locus Names:BARBAKC583_0151
OrganismiBartonella bacilliformis (strain ATCC 35685 / KC583)
Taxonomic identifieri360095 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000000643: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 167167Crossover junction endodeoxyribonuclease RuvCUniRule annotation
PRO_1000002719Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360095.BARBAKC583_0151.

Structurei

3D structure databases

ProteinModelPortaliA1UR86.

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvC family.

Phylogenomic databases

eggNOGiCOG0817.
HOGENOMiHOG000012181.
KOiK01159.
OMAiRQVQEMV.
OrthoDBiEOG6RG044.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00034. RuvC.
InterProiIPR012337. RNaseH-like_dom.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view]
PfamiPF02075. RuvC. 1 hit.
[Graphical view]
PRINTSiPR00696. RSOLVASERUVC.
SUPFAMiSSF53098. SSF53098. 1 hit.
TIGRFAMsiTIGR00228. ruvC. 1 hit.

Sequencei

Sequence statusi: Complete.

A1UR86-1 [UniParc]FASTAAdd to Basket

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MVEKIRIIGI DPGLRRTGWG IIDFLGNHMH FVASGTLHSD AQLNLASRLH    50
QLHKGLSEVV HQFMPHEAAV EHVFVNKDAT ATLKLGQARA IALLVPAQAG 100
LPVFEYAPNT IKKSVIGVGH GAKEQIHMMV KRLLPRAEFD GHDAADALAL 150
VICHSAHRTN FAHRIKG 167
Length:167
Mass (Da):18,258
Last modified:February 6, 2007 - v1
Checksum:i70432678F28DB03E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000524 Genomic DNA. Translation: ABM45441.1.
RefSeqiYP_988489.1. NC_008783.1.

Genome annotation databases

EnsemblBacteriaiABM45441; ABM45441; BARBAKC583_0151.
GeneIDi4684450.
KEGGibbk:BARBAKC583_0151.
PATRICi20536579. VBIBarBac6912_0151.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000524 Genomic DNA. Translation: ABM45441.1 .
RefSeqi YP_988489.1. NC_008783.1.

3D structure databases

ProteinModelPortali A1UR86.
ModBasei Search...

Protein-protein interaction databases

STRINGi 360095.BARBAKC583_0151.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM45441 ; ABM45441 ; BARBAKC583_0151 .
GeneIDi 4684450.
KEGGi bbk:BARBAKC583_0151.
PATRICi 20536579. VBIBarBac6912_0151.

Phylogenomic databases

eggNOGi COG0817.
HOGENOMi HOG000012181.
KOi K01159.
OMAi RQVQEMV.
OrthoDBi EOG6RG044.

Enzyme and pathway databases

BioCyci BBAC360095:GHRY-151-MONOMER.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
HAMAPi MF_00034. RuvC.
InterProi IPR012337. RNaseH-like_dom.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view ]
Pfami PF02075. RuvC. 1 hit.
[Graphical view ]
PRINTSi PR00696. RSOLVASERUVC.
SUPFAMi SSF53098. SSF53098. 1 hit.
TIGRFAMsi TIGR00228. ruvC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35685 / KC583.

Entry informationi

Entry nameiRUVC_BARBK
AccessioniPrimary (citable) accession number: A1UR86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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