A1UR75 (PGK_BARBK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglycerate kinase
EC=2.7.2.3

Gene names

Name:	pgk
Ordered Locus Names:	BARBAKC583_0140

Organism

Bartonella bacilliformis (strain ATCC 35685 / KC583) [Complete proteome] [HAMAP]

Taxonomic identifier

360095 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	400 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP MF_00145
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP MF_00145
Subunit structure	Monomer By similarity. HAMAP MF_00145
Subcellular location	Cytoplasm Potential HAMAP MF_00145.
Sequence similarities	Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglycerate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 400	400	Phosphoglycerate kinase HAMAP MF_00145		PRO_1000057969
Regions
	Nucleotide binding	353 – 356	4	ATP By similarity
	Region	21 – 23	3	Substrate binding By similarity
	Region	59 – 62	4	Substrate binding By similarity
Sites
	Binding site	36	1	Substrate By similarity
	Binding site	118	1	Substrate By similarity
	Binding site	151	1	Substrate By similarity
	Binding site	201	1	ATP By similarity
	Binding site	323	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1UR75 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: EA63F29C60216A6B	FASTA	400	43,421
	10 20 30 40 50 60 MKFRTINEAN VSGKRVLVRV DFNVPMSQGK VCDNTRLERH KETICALQKR GAKIILLSHC 70 80 90 100 110 120 SRPRGKIVPE LSLRPVAKAL ETIMGQQIFF VEECIGAPVQ TAVEALQEGQ ILLLENLRFY 130 140 150 160 170 180 KEEEDNNADF AEALAQQGDL YVNDAFSVSH RAHASVEAIT HYLPSYAGMA LQRELQALEK 190 200 210 220 230 240 GLDNPKKPVT AIVGGAKVSS KLFVLNHLVT KVDYLVIGGG MANNFLMAQG HNVGKSLCEP 250 260 270 280 290 300 MLMDMVKDVI EKARESHCTL VLPVDAVVGL QCETGTPHHH CMIEAIPDEG MILDIGEHSI 310 320 330 340 350 360 ARINTVIDAS ATLVWNGPLG VFEVSPFDHG TIAVARYAAA RSQKGHCVSI AGGGDTVFAL 370 380 390 400 NHAGVADDFT YLSTAGGAFL EWMEGKTLPG VLALMQDLKN

References

[1]

Hendrix L., Mohamoud Y., Radune D., Shvartsbeyn A., Daugherty S., Dodson R., Durkin A.S., Harkins D., Huot H., Kothari S.P., Madupu R., Li J., Nelson W.C., Shrivastava S., Giglio M.G., Haft D., Selengut J., Fraser-Ligget C., Seshadri R. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35685 / KC583.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000524 Genomic DNA. Translation: ABM45059.1.
RefSeq	YP_988478.1. NC_008783.1.
3D structure databases
ProteinModelPortal	A1UR75.
ModBase	Search...
Protein-protein interaction databases
STRING	A1UR75.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4684315.
GenomeReviews	Gene locus BARBAKC583_0140 in contig CP000524_GR.
KEGG	bbk:BARBAKC583_0140.
NMPDR	fig|360095.3.peg.1104.
PATRIC	20536557. VBIBarBac6912_0140.
TIGR	BARBAKC583_0140.
Phylogenomic databases
eggNOG	COG0126.
HOGENOM	HBG453500.
OMA	CTIHLPL.
ProtClustDB	PRK00073.
Enzyme and pathway databases
BioCyc	BBAC360095:BARBAKC583_0140-MONOMER.
Family and domain databases
HAMAP	MF_00145. Phosphoglyc_kinase. [Tree]
InterPro	IPR001576. Phosphoglycerate_kinase. IPR015901. Phosphoglycerate_kinase_C. IPR015911. Phosphoglycerate_kinase_CS. IPR015824. Phosphoglycerate_kinase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.1270. Phosphoglycerate_kinase_C. 1 hit. G3DSA:3.40.50.1260. Phosphoglycerate_kinase_N. 1 hit.
KO	K00927.
PANTHER	PTHR11406. PGK. 1 hit.
Pfam	PF00162. PGK. 1 hit. [Graphical view]
PIRSF	PIRSF000724. Pgk. 1 hit.
PRINTS	PR00477. PHGLYCKINASE.
SUPFAM	SSF53748. PGK. 1 hit.
PROSITE	PS00111. PGLYCERATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGK_BARBK

Accession

Primary (citable) accession number: A1UR75

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program