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A1UR39

- SYL_BARBK

UniProt

A1UR39 - SYL_BARBK

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Protein
Leucine--tRNA ligase
Gene
leuS, BARBAKC583_0104
Organism
Bartonella bacilliformis (strain ATCC 35685 / KC583)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei636 – 6361ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBBAC360095:GHRY-104-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:BARBAKC583_0104
OrganismiBartonella bacilliformis (strain ATCC 35685 / KC583)
Taxonomic identifieri360095 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000000643: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 875875Leucine--tRNA ligaseUniRule annotation
PRO_1000009295Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360095.BARBAKC583_0104.

Structurei

3D structure databases

ProteinModelPortaliA1UR39.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionUniRule annotation
Add
BLAST
Motifi633 – 6375"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A1UR39-1 [UniParc]FASTAAdd to Basket

« Hide

MTIERYNPRA QEQKWQAIWD EKKIFQTSHE DEGEKYYVLE MFPYPSGRIH    50
MGHVRNYTMG DVVARYKRAK GMNVLHPMGW DAFGMPAENA AMQNKVHPKA 100
WTYQNIAAMR KQLQKLGLSI DWSREFATCD VDYYHRQQMI FLDLYQKGLV 150
VRKVAKVNWD PVDQTVLANE QVIDGRGWRS GALVEQRELT QWFFKITEFG 200
EGLLARLDDL TEWPDKVRVM QKNWIGKSQG LYIRWALDKT QLPHNDGCEG 250
FDEITCYSTR PDTLFGASFL ALSVDHPVAQ ALARNDEELR AFIEMCRCGS 300
TTTEALETAE KQGFRTGVLA VHPLNPAVRL PVYIANFVLM DYGTGAIFGC 350
PAHDQRDLDF ARKYDLPVQI VVAPKEAEEQ DFTLSDTAYT GDGVMINSDF 400
LNGLTPKDAF EVVAQHLEKQ VLNGQPQGQK TVQFRLRDWG VSRQRYWGCP 450
IPMIHCAACG VVPVPRADLP VVLPEDVTFD RPGNPLARHE TWQTVACPSC 500
GQPAKRETDT MDTFVDSSWY YARFTAPWAQ EPTDQDIAAQ WLPVQQYIGG 550
IEHAILHLLY ARFFMRAMKL AGHVNADEPF TGLFTQGMVV HETYRDAQGW 600
VAPDEVSIVE QDGKRRAYKL TDQSEVTIGS IEKMSKSKKN VVDPDDIISS 650
YGADTARWFM LSDSPPERDV IWSESGIEGA HRFVQRVWRC VALSAPILST 700
IEPCAGHQGE ALELSKAAHR TLCAVEDDLE KLAFNRAVAR LYEFLNIMAP 750
LLNTVADLDD EMKSALRQAM DFFCAMIAPM MPHLAEECHA ALGGKTLMSE 800
CAWPVYDKAL IVEDSVTLPV QINGKKRGDV TVPVTADQAE IEQAVLALSF 850
VQAQLAGKSV KKMIIVPKRI VNVVL 875
Length:875
Mass (Da):98,727
Last modified:February 6, 2007 - v1
Checksum:iDF9B351DA23E27B8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000524 Genomic DNA. Translation: ABM45658.1.
RefSeqiWP_005765856.1. NC_008783.1.
YP_988442.1. NC_008783.1.

Genome annotation databases

EnsemblBacteriaiABM45658; ABM45658; BARBAKC583_0104.
GeneIDi4684393.
KEGGibbk:BARBAKC583_0104.
PATRICi20536485. VBIBarBac6912_0104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000524 Genomic DNA. Translation: ABM45658.1 .
RefSeqi WP_005765856.1. NC_008783.1.
YP_988442.1. NC_008783.1.

3D structure databases

ProteinModelPortali A1UR39.
ModBasei Search...

Protein-protein interaction databases

STRINGi 360095.BARBAKC583_0104.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM45658 ; ABM45658 ; BARBAKC583_0104 .
GeneIDi 4684393.
KEGGi bbk:BARBAKC583_0104.
PATRICi 20536485. VBIBarBac6912_0104.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BBAC360095:GHRY-104-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35685 / KC583.

Entry informationi

Entry nameiSYL_BARBK
AccessioniPrimary (citable) accession number: A1UR39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi