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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bartonella bacilliformis (strain ATCC 35685 / KC583)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei636ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBBAC360095:G1G7W-104-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:BARBAKC583_0104
OrganismiBartonella bacilliformis (strain ATCC 35685 / KC583)
Taxonomic identifieri360095 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi
  • UP000000643 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000092951 – 875Leucine--tRNA ligaseAdd BLAST875

Proteomic databases

PRIDEiA1UR39

Interactioni

Protein-protein interaction databases

STRINGi360095.BARBAKC583_0104

Structurei

3D structure databases

ProteinModelPortaliA1UR39
SMRiA1UR39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 53"HIGH" regionAdd BLAST11
Motifi633 – 637"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A1UR39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIERYNPRA QEQKWQAIWD EKKIFQTSHE DEGEKYYVLE MFPYPSGRIH
60 70 80 90 100
MGHVRNYTMG DVVARYKRAK GMNVLHPMGW DAFGMPAENA AMQNKVHPKA
110 120 130 140 150
WTYQNIAAMR KQLQKLGLSI DWSREFATCD VDYYHRQQMI FLDLYQKGLV
160 170 180 190 200
VRKVAKVNWD PVDQTVLANE QVIDGRGWRS GALVEQRELT QWFFKITEFG
210 220 230 240 250
EGLLARLDDL TEWPDKVRVM QKNWIGKSQG LYIRWALDKT QLPHNDGCEG
260 270 280 290 300
FDEITCYSTR PDTLFGASFL ALSVDHPVAQ ALARNDEELR AFIEMCRCGS
310 320 330 340 350
TTTEALETAE KQGFRTGVLA VHPLNPAVRL PVYIANFVLM DYGTGAIFGC
360 370 380 390 400
PAHDQRDLDF ARKYDLPVQI VVAPKEAEEQ DFTLSDTAYT GDGVMINSDF
410 420 430 440 450
LNGLTPKDAF EVVAQHLEKQ VLNGQPQGQK TVQFRLRDWG VSRQRYWGCP
460 470 480 490 500
IPMIHCAACG VVPVPRADLP VVLPEDVTFD RPGNPLARHE TWQTVACPSC
510 520 530 540 550
GQPAKRETDT MDTFVDSSWY YARFTAPWAQ EPTDQDIAAQ WLPVQQYIGG
560 570 580 590 600
IEHAILHLLY ARFFMRAMKL AGHVNADEPF TGLFTQGMVV HETYRDAQGW
610 620 630 640 650
VAPDEVSIVE QDGKRRAYKL TDQSEVTIGS IEKMSKSKKN VVDPDDIISS
660 670 680 690 700
YGADTARWFM LSDSPPERDV IWSESGIEGA HRFVQRVWRC VALSAPILST
710 720 730 740 750
IEPCAGHQGE ALELSKAAHR TLCAVEDDLE KLAFNRAVAR LYEFLNIMAP
760 770 780 790 800
LLNTVADLDD EMKSALRQAM DFFCAMIAPM MPHLAEECHA ALGGKTLMSE
810 820 830 840 850
CAWPVYDKAL IVEDSVTLPV QINGKKRGDV TVPVTADQAE IEQAVLALSF
860 870
VQAQLAGKSV KKMIIVPKRI VNVVL
Length:875
Mass (Da):98,727
Last modified:February 6, 2007 - v1
Checksum:iDF9B351DA23E27B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000524 Genomic DNA Translation: ABM45658.1
RefSeqiWP_005765856.1, NC_008783.1

Genome annotation databases

EnsemblBacteriaiABM45658; ABM45658; BARBAKC583_0104
GeneIDi4684393
KEGGibbk:BARBAKC583_0104
PATRICifig|360095.6.peg.104

Similar proteinsi

Entry informationi

Entry nameiSYL_BARBK
AccessioniPrimary (citable) accession number: A1UR39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health