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A1UR39

- SYL_BARBK

UniProt

A1UR39 - SYL_BARBK

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bartonella bacilliformis (strain ATCC 35685 / KC583)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei636 – 6361ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBBAC360095:GHRY-104-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:BARBAKC583_0104
    OrganismiBartonella bacilliformis (strain ATCC 35685 / KC583)
    Taxonomic identifieri360095 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
    ProteomesiUP000000643: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 875875Leucine--tRNA ligasePRO_1000009295Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi360095.BARBAKC583_0104.

    Structurei

    3D structure databases

    ProteinModelPortaliA1UR39.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 5311"HIGH" regionAdd
    BLAST
    Motifi633 – 6375"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A1UR39-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTIERYNPRA QEQKWQAIWD EKKIFQTSHE DEGEKYYVLE MFPYPSGRIH    50
    MGHVRNYTMG DVVARYKRAK GMNVLHPMGW DAFGMPAENA AMQNKVHPKA 100
    WTYQNIAAMR KQLQKLGLSI DWSREFATCD VDYYHRQQMI FLDLYQKGLV 150
    VRKVAKVNWD PVDQTVLANE QVIDGRGWRS GALVEQRELT QWFFKITEFG 200
    EGLLARLDDL TEWPDKVRVM QKNWIGKSQG LYIRWALDKT QLPHNDGCEG 250
    FDEITCYSTR PDTLFGASFL ALSVDHPVAQ ALARNDEELR AFIEMCRCGS 300
    TTTEALETAE KQGFRTGVLA VHPLNPAVRL PVYIANFVLM DYGTGAIFGC 350
    PAHDQRDLDF ARKYDLPVQI VVAPKEAEEQ DFTLSDTAYT GDGVMINSDF 400
    LNGLTPKDAF EVVAQHLEKQ VLNGQPQGQK TVQFRLRDWG VSRQRYWGCP 450
    IPMIHCAACG VVPVPRADLP VVLPEDVTFD RPGNPLARHE TWQTVACPSC 500
    GQPAKRETDT MDTFVDSSWY YARFTAPWAQ EPTDQDIAAQ WLPVQQYIGG 550
    IEHAILHLLY ARFFMRAMKL AGHVNADEPF TGLFTQGMVV HETYRDAQGW 600
    VAPDEVSIVE QDGKRRAYKL TDQSEVTIGS IEKMSKSKKN VVDPDDIISS 650
    YGADTARWFM LSDSPPERDV IWSESGIEGA HRFVQRVWRC VALSAPILST 700
    IEPCAGHQGE ALELSKAAHR TLCAVEDDLE KLAFNRAVAR LYEFLNIMAP 750
    LLNTVADLDD EMKSALRQAM DFFCAMIAPM MPHLAEECHA ALGGKTLMSE 800
    CAWPVYDKAL IVEDSVTLPV QINGKKRGDV TVPVTADQAE IEQAVLALSF 850
    VQAQLAGKSV KKMIIVPKRI VNVVL 875
    Length:875
    Mass (Da):98,727
    Last modified:February 6, 2007 - v1
    Checksum:iDF9B351DA23E27B8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000524 Genomic DNA. Translation: ABM45658.1.
    RefSeqiWP_005765856.1. NC_008783.1.
    YP_988442.1. NC_008783.1.

    Genome annotation databases

    EnsemblBacteriaiABM45658; ABM45658; BARBAKC583_0104.
    GeneIDi4684393.
    KEGGibbk:BARBAKC583_0104.
    PATRICi20536485. VBIBarBac6912_0104.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000524 Genomic DNA. Translation: ABM45658.1 .
    RefSeqi WP_005765856.1. NC_008783.1.
    YP_988442.1. NC_008783.1.

    3D structure databases

    ProteinModelPortali A1UR39.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 360095.BARBAKC583_0104.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM45658 ; ABM45658 ; BARBAKC583_0104 .
    GeneIDi 4684393.
    KEGGi bbk:BARBAKC583_0104.
    PATRICi 20536485. VBIBarBac6912_0104.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci BBAC360095:GHRY-104-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35685 / KC583.

    Entry informationi

    Entry nameiSYL_BARBK
    AccessioniPrimary (citable) accession number: A1UR39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3