A1UR36 (ACSA_BARBK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase
EC=6.2.1.1

Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme

Gene names

Name:	acsA
Ordered Locus Names:	BARBAKC583_0101

Organism

Bartonella bacilliformis (strain ATCC 35685 / KC583) [Complete proteome] [HAMAP]

Taxonomic identifier

360095 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella

Protein attributes

Sequence length	652 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 652	652	Acetyl-coenzyme A synthetase HAMAP MF_01123		PRO_1000065269
Sites
	Active site	517	1	By similarity
Amino acid modifications
	Modified residue	609	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A1UR36 [UniParc]. Last modified February 6, 2007. Version 1. Checksum: 8F1DBAD1364233B3	FASTA	652	73,449
	10 20 30 40 50 60 MSERIYPIPV DIEKNALIDQ DTYQKWYQKS IEDPTSFWGE HGQRIEWFKP YTKVKNASFN 70 80 90 100 110 120 DNVSIKWYED GITNVAYNCI DRHLKDRGNE IALIWESDNP YSDKKITYNE LYEHVCRFAN 130 140 150 160 170 180 ILKNHGVKKG DRVSIYLPMI PEAAYAMLAC ARIGAIHSVI FAGFSSEAIA GRLIDGQSTF 190 200 210 220 230 240 IITADHALRG DKTIPLKDNV DRAIHIAACQ NVNVTQVMVI RRTSKIIHWV NGRDFWYHEE 250 260 270 280 290 300 MPHATPDCPP EHMNAEDPLF ILYTSGSTGK PKGVLHTTGG YLVYASMTHQ YVFDYHPGEI 310 320 330 340 350 360 YWCTADIGWI TGHSYLVYGP LCNGATTLMF EGSPTFPDEG RFWEIVDKHK VNIFYTAPTA 370 380 390 400 410 420 IRALMGAGDS FVKRSQRTSL RLLGTVGEPI NPEAWKWFYH TVGDSRCPIL DTWWQTETGG 430 440 450 460 470 480 HIITPLPGAT KLKAGSATHP FFGIQVQLVD PQGNILKGEA EGNLCIVDSW PGQMRTLYNN 490 500 510 520 530 540 HQRFVETYFS TYKGKYFTGD GCKRDKDSYY WITGRVDDIL NISGHRLGTA EIESALISHP 550 560 570 580 590 600 AVSEAAVVGY PHPIKGQGIY SFVTLMAGTQ PSATLHQNLI QHVRQEIGSI ATLDKIQFAP 610 620 630 640 650 HLPKTRSGKI MRRILRKIAA NNFDNLGDIS TLAEPQIVDN LIANRQNIEE AA

References

[1]

Hendrix L., Mohamoud Y., Radune D., Shvartsbeyn A., Daugherty S., Dodson R., Durkin A.S., Harkins D., Huot H., Kothari S.P., Madupu R., Li J., Nelson W.C., Shrivastava S., Giglio M.G., Haft D., Selengut J., Fraser-Ligget C., Seshadri R. Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35685 / KC583.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000524 Genomic DNA. Translation: ABM44660.1.
RefSeq	YP_988439.1. NC_008783.1.
3D structure databases
ProteinModelPortal	A1UR36.
SMR	A1UR36. Positions 6-646.
ModBase	Search...
Protein-protein interaction databases
STRING	A1UR36.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4684414.
GenomeReviews	Gene locus BARBAKC583_0101 in contig CP000524_GR.
KEGG	bbk:BARBAKC583_0101.
NMPDR	fig|360095.3.peg.1072.
PATRIC	20536479. VBIBarBac6912_0101.
TIGR	BARBAKC583_0101.
Phylogenomic databases
eggNOG	COG0365.
HOGENOM	HBG547964.
OMA	WNCIERN.
ProtClustDB	PRK00174.
Enzyme and pathway databases
BioCyc	BBAC360095:BARBAKC583_0101-MONOMER.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACSA_BARBK

Accession

Primary (citable) accession number: A1UR36

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	February 6, 2007
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program