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A1UR09

- PUR9_BARBK

UniProt

A1UR09 - PUR9_BARBK

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Bartonella bacilliformis (strain ATCC 35685 / KC583)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciBBAC360095:GHRY-74-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:BARBAKC583_0074
    OrganismiBartonella bacilliformis (strain ATCC 35685 / KC583)
    Taxonomic identifieri360095 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
    ProteomesiUP000000643: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 538538Bifunctional purine biosynthesis protein PurHPRO_1000018844Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi360095.BARBAKC583_0074.

    Structurei

    3D structure databases

    ProteinModelPortaliA1UR09.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiRAFKTDP.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A1UR09-1 [UniParc]FASTAAdd to Basket

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    MVVVSQNYPT PDLHRVRRAL LSVFDKTGLV EFAQELHAYG IELISTGGTS    50
    ESLIAAGLPV KDVSEVTGFP QIMDGRVKTL HPLIHGGLLG VRDDPSHKAA 100
    MEKHGICGID LVVVNLYPFE KTWQSGADSQ TIIENIDIGG PAMIRAAAKN 150
    HAYTGVVTAV SDYDVVLAEL KQHNGCLSFS LRRQLAARAY EHTAAYDAAI 200
    AAWFAQDLEV EMPSWQNFSG HFESMMRYGE NPHQRAAFYR TRDTRFGVAT 250
    AKVLQGKELS YNNMNDADAA FELVAEFDPQ RTAAVALIKH ANPCGVAEGQ 300
    SLKEAYLKAL MCDSVSAFGG IVALNQPLDE ECAAEIVKLF TEVIIAPDAT 350
    EAACNIIAQK KNLRLLITGG VPDPRCGGLT VKTLAGGVLV QSRDNAVVDD 400
    FDLQIVTKRA PSQDEMRDLQ FAFRVVKHVK SNAIVYAKNS ATVGIGAGQM 450
    SRLDSARIAV HKAEDNAKRM GLTESLTRGS VVASDAFFPF ADGLISAAEA 500
    GVTAVIQPGG SIRDQEVIEA ADARGLAMVF TGVRHFRH 538
    Length:538
    Mass (Da):58,021
    Last modified:February 6, 2007 - v1
    Checksum:iC481387E41485124
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000524 Genomic DNA. Translation: ABM45521.1.
    RefSeqiYP_988412.1. NC_008783.1.

    Genome annotation databases

    EnsemblBacteriaiABM45521; ABM45521; BARBAKC583_0074.
    GeneIDi4684296.
    KEGGibbk:BARBAKC583_0074.
    PATRICi20536425. VBIBarBac6912_0074.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000524 Genomic DNA. Translation: ABM45521.1 .
    RefSeqi YP_988412.1. NC_008783.1.

    3D structure databases

    ProteinModelPortali A1UR09.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 360095.BARBAKC583_0074.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM45521 ; ABM45521 ; BARBAKC583_0074 .
    GeneIDi 4684296.
    KEGGi bbk:BARBAKC583_0074.
    PATRICi 20536425. VBIBarBac6912_0074.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi RAFKTDP.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci BBAC360095:GHRY-74-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35685 / KC583.

    Entry informationi

    Entry nameiPUR9_BARBK
    AccessioniPrimary (citable) accession number: A1UR09
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3