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A1UR09

- PUR9_BARBK

UniProt

A1UR09 - PUR9_BARBK

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, BARBAKC583_0074
Organism
Bartonella bacilliformis (strain ATCC 35685 / KC583)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciBBAC360095:GHRY-74-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:BARBAKC583_0074
OrganismiBartonella bacilliformis (strain ATCC 35685 / KC583)
Taxonomic identifieri360095 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000000643: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 538538Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000018844Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360095.BARBAKC583_0074.

Structurei

3D structure databases

ProteinModelPortaliA1UR09.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A1UR09-1 [UniParc]FASTAAdd to Basket

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MVVVSQNYPT PDLHRVRRAL LSVFDKTGLV EFAQELHAYG IELISTGGTS    50
ESLIAAGLPV KDVSEVTGFP QIMDGRVKTL HPLIHGGLLG VRDDPSHKAA 100
MEKHGICGID LVVVNLYPFE KTWQSGADSQ TIIENIDIGG PAMIRAAAKN 150
HAYTGVVTAV SDYDVVLAEL KQHNGCLSFS LRRQLAARAY EHTAAYDAAI 200
AAWFAQDLEV EMPSWQNFSG HFESMMRYGE NPHQRAAFYR TRDTRFGVAT 250
AKVLQGKELS YNNMNDADAA FELVAEFDPQ RTAAVALIKH ANPCGVAEGQ 300
SLKEAYLKAL MCDSVSAFGG IVALNQPLDE ECAAEIVKLF TEVIIAPDAT 350
EAACNIIAQK KNLRLLITGG VPDPRCGGLT VKTLAGGVLV QSRDNAVVDD 400
FDLQIVTKRA PSQDEMRDLQ FAFRVVKHVK SNAIVYAKNS ATVGIGAGQM 450
SRLDSARIAV HKAEDNAKRM GLTESLTRGS VVASDAFFPF ADGLISAAEA 500
GVTAVIQPGG SIRDQEVIEA ADARGLAMVF TGVRHFRH 538
Length:538
Mass (Da):58,021
Last modified:February 6, 2007 - v1
Checksum:iC481387E41485124
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000524 Genomic DNA. Translation: ABM45521.1.
RefSeqiYP_988412.1. NC_008783.1.

Genome annotation databases

EnsemblBacteriaiABM45521; ABM45521; BARBAKC583_0074.
GeneIDi4684296.
KEGGibbk:BARBAKC583_0074.
PATRICi20536425. VBIBarBac6912_0074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000524 Genomic DNA. Translation: ABM45521.1 .
RefSeqi YP_988412.1. NC_008783.1.

3D structure databases

ProteinModelPortali A1UR09.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360095.BARBAKC583_0074.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM45521 ; ABM45521 ; BARBAKC583_0074 .
GeneIDi 4684296.
KEGGi bbk:BARBAKC583_0074.
PATRICi 20536425. VBIBarBac6912_0074.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci BBAC360095:GHRY-74-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35685 / KC583.

Entry informationi

Entry nameiPUR9_BARBK
AccessioniPrimary (citable) accession number: A1UR09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 6, 2007
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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